PRME vs. NTLA

Last updated Aug 1, 2026

PRME (Prime Medicine Inc. Common Stock) and NTLA (Intellia Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, PRME returned -41.84%/yr vs -36.11%/yr for NTLA. Their 0.59 correlation means they have sometimes moved together and sometimes differently.

Performance

PRME vs. NTLA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Prime Medicine Inc. Common Stock (PRME) and Intellia Therapeutics, Inc. (NTLA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PRME achieves a -15.85% return, which is significantly lower than NTLA's 18.80% return.

PRME

• 1D: -3.31%
• 1M: -24.55%
• 6M: -23.36%
• YTD: -15.85%
• 1Y: -27.72%
• 3Y*: -41.84%
• 5Y*: —
• 10Y*: —
• ALL TIME*: -39.06%

NTLA

• 1D: -3.70%
• 1M: -39.18%
• 6M: -18.78%
• YTD: 18.80%
• 1Y: -7.05%
• 3Y*: -36.11%
• 5Y*: -40.39%
• 10Y*: -5.06%
• ALL TIME*: -6.82%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
NTLA Intellia Therapeutics, Inc.	$37.16M	$55.27M	$78.35M
PRME Prime Medicine Inc. Common Stock	$7.89M	$13.77M	$11.21M

PRME vs. NTLA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
PRME Prime Medicine Inc. Common Stock	-15.85%	18.84%	-67.04%	-52.31%	-2.06%
NTLA Intellia Therapeutics, Inc.	18.80%	-22.90%	-61.76%	-12.61%	-33.80%

Correlation

The correlation between PRME and NTLA is 0.67, which is moderate. They have sometimes moved together and sometimes differently, sharing some price drivers without tracking each other closely.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.67
Correlation (3Y) Balances recent behavior with more history.	0.63
Correlation (All Time) Calculated using the full available price history since Oct 20, 2022	0.59

The correlation between PRME and NTLA has been stable across timeframes, ranging from 0.59 to 0.67 - a consistent structural relationship.

Fundamentals

Market Cap PRME : $527.40M NTLA : $1.20B
EPS PRME : -$1.22 NTLA : -$3.51
PS Ratio PRME : 148.96 NTLA : 18.16
PB Ratio PRME : 6.74 NTLA : 2.04
Total Revenue (TTM) PRME : $3.18M NTLA : $66.09M
Gross Profit (TTM) PRME : -$4.14M NTLA : -$33.92M
EBITDA (TTM) PRME : -$195.72M NTLA : -$299.32M

Return for Risk

PRME vs. NTLA — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

PRME

PRME Risk / Return Rank: 36
PRME Sharpe Ratio Rank: 34
PRME Sortino Ratio Rank: 40
PRME Omega Ratio Rank: 39
PRME Calmar Ratio Rank: 32
PRME Martin Ratio Rank: 34

NTLA

NTLA Risk / Return Rank: 45
NTLA Sharpe Ratio Rank: 41
NTLA Sortino Ratio Rank: 50
NTLA Omega Ratio Rank: 50
NTLA Calmar Ratio Rank: 41
NTLA Martin Ratio Rank: 41

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

PRME vs. NTLA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Prime Medicine Inc. Common Stock (PRME) and Intellia Therapeutics, Inc. (NTLA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	PRME	NTLA	Difference
Sharpe ratio: Return per unit of total volatility	-0.24	-0.08	-0.16
Sortino ratio: Return per unit of downside risk	0.26	0.61	-0.35
Omega ratio: Gain probability vs. loss probability	1.03	1.08	-0.06
Calmar ratio: Return relative to maximum drawdown	-0.37	-0.12	-0.25
Martin ratio: Return relative to average drawdown	-0.54	-0.17	-0.37

PRME vs. NTLA - Sharpe Ratio Comparison

The current PRME Sharpe Ratio is -0.24, which is lower than the NTLA Sharpe Ratio of -0.08. The chart below compares the historical Sharpe Ratios of PRME and NTLA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

PRME vs. NTLA - Drawdown Comparison

The maximum PRME drawdown since its inception was -94.55%, roughly equal to the maximum NTLA drawdown of -96.45%. Use the drawdown chart below to compare losses from any high point for PRME and NTLA.

Drawdown Indicators

	PRME	NTLA	Difference
Max Drawdown Largest peak-to-trough decline	-94.55%	-96.45%	+1.90%
Max Drawdown (1Y) Largest decline over 1 year	-59.52%	-71.27%	+11.75%
Max Drawdown (3Y) Largest decline over 3 years	-91.64%	-84.31%	-7.33%
Max Drawdown (5Y) Largest decline over 5 years	—	-96.45%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-96.45%	—
Current Drawdown Current decline from peak	-86.17%	-93.96%	+7.79%
Average Drawdown Average peak-to-trough decline	-66.15%	-57.56%	-8.59%
Ulcer Index Depth and duration of drawdowns from previous peaks	40.94%	48.81%	-7.87%

Volatility

PRME vs. NTLA - Volatility Comparison

Prime Medicine Inc. Common Stock (PRME) has a higher volatility of 24.52% compared to Intellia Therapeutics, Inc. (NTLA) at 18.85%. This indicates that PRME's price experiences larger fluctuations and is considered to be riskier than NTLA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PRME	NTLA	Difference
Volatility (1M) Calculated over the trailing 1-month period	24.52%	18.85%	+5.67%
Volatility (6M) Calculated over the trailing 6-month period	55.01%	56.80%	-1.79%
Volatility (1Y) Calculated over the trailing 1-year period	90.13%	98.08%	-7.95%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	90.24%	78.01%	+12.23%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	90.24%	78.82%	+11.42%

Dividends

PRME vs. NTLA - Dividend Comparison

Neither PRME nor NTLA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both PRME and NTLA in my portfolio?

PRME and NTLA have a correlation of 0.67, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PRME or NTLA?

PRME has higher volatility (24.52%) compared to NTLA (18.85%). In terms of maximum drawdown, PRME dropped -94.55% vs NTLA's -96.45%.

Which has better risk-adjusted returns?

NTLA currently has the higher Sharpe Ratio (-0.08 vs -0.24), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.