PRME vs. QQQ

Last updated Apr 1, 2026

Compare and contrast key facts about Prime Medicine Inc. Common Stock (PRME) and Invesco QQQ ETF (QQQ).

QQQ is a passively managed fund by Invesco that tracks the performance of the NASDAQ-100 Index. It was launched on Mar 10, 1999.

Performance

PRME vs. QQQ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Prime Medicine Inc. Common Stock (PRME) and Invesco QQQ ETF (QQQ). The values are adjusted to include any dividend payments, if applicable.

PRME vs. QQQ - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
PRME Prime Medicine Inc. Common Stock	0.29%	18.84%	-67.04%	-52.31%	20.88%
QQQ Invesco QQQ ETF	-5.93%	20.77%	25.58%	54.86%	-0.81%

Returns By Period

In the year-to-date period, PRME achieves a 0.29% return, which is significantly higher than QQQ's -5.93% return.

PRME

• 1D: 10.48%
• 1M: -24.68%
• YTD: 0.29%
• 6M: -37.18%
• 1Y: 74.87%
• 3Y*: -34.35%
• 5Y*: —
• 10Y*: —

QQQ

• 1D: 3.39%
• 1M: -4.84%
• YTD: -5.93%
• 6M: -3.62%
• 1Y: 23.68%
• 3Y*: 22.32%
• 5Y*: 12.88%
• 10Y*: 18.85%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PRME vs. QQQ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PRME

PRME Risk / Return Rank: 68
PRME Sharpe Ratio Rank: 65
PRME Sortino Ratio Rank: 74
PRME Omega Ratio Rank: 66
PRME Calmar Ratio Rank: 70
PRME Martin Ratio Rank: 63

QQQ

QQQ Risk / Return Rank: 69
QQQ Sharpe Ratio Rank: 63
QQQ Sortino Ratio Rank: 68
QQQ Omega Ratio Rank: 67
QQQ Calmar Ratio Rank: 76
QQQ Martin Ratio Rank: 73

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PRME vs. QQQ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Prime Medicine Inc. Common Stock (PRME) and Invesco QQQ ETF (QQQ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PRME	QQQ	Difference
Sharpe ratio Return per unit of total volatility	0.67	1.05	-0.38
Sortino ratio Return per unit of downside risk	1.78	1.63	+0.15
Omega ratio Gain probability vs. loss probability	1.19	1.23	-0.05
Calmar ratio Return relative to maximum drawdown	1.42	1.88	-0.46
Martin ratio Return relative to average drawdown	2.29	6.95	-4.66
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PRME vs. QQQ - Sharpe Ratio Comparison

The current PRME Sharpe Ratio is 0.67, which is lower than the QQQ Sharpe Ratio of 1.05. The chart below compares the historical Sharpe Ratios of PRME and QQQ, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PRME	QQQ	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.67	1.05	-0.38
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.58	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.85	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.39	0.37	-0.76

Correlation

The correlation between PRME and QQQ is 0.30, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PRME vs. QQQ - Dividend Comparison

PRME has not paid dividends to shareholders, while QQQ's dividend yield for the trailing twelve months is around 0.49%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PRME Prime Medicine Inc. Common Stock	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
QQQ Invesco QQQ ETF	0.49%	0.45%	0.56%	0.62%	0.80%	0.43%	0.55%	0.74%	0.91%	0.84%	1.06%	0.99%

Drawdowns

PRME vs. QQQ - Drawdown Comparison

The maximum PRME drawdown since its inception was -94.55%, which is greater than QQQ's maximum drawdown of -82.97%. Use the drawdown chart below to compare losses from any high point for PRME and QQQ.

Drawdown Indicators

	PRME	QQQ	Difference
Max Drawdown Largest peak-to-trough decline	-94.55%	-82.97%	-11.58%
Max Drawdown (1Y) Largest decline over 1 year	-52.77%	-12.62%	-40.15%
Max Drawdown (5Y) Largest decline over 5 years	—	-35.12%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-35.12%	—
Current Drawdown Current decline from peak	-83.52%	-8.98%	-74.54%
Average Drawdown Average peak-to-trough decline	-64.37%	-32.99%	-31.38%
Ulcer Index Depth and duration of drawdowns from previous peaks	32.70%	3.41%	+29.29%

Volatility

PRME vs. QQQ - Volatility Comparison

Prime Medicine Inc. Common Stock (PRME) has a higher volatility of 21.00% compared to Invesco QQQ ETF (QQQ) at 6.51%. This indicates that PRME's price experiences larger fluctuations and is considered to be riskier than QQQ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PRME	QQQ	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.00%	6.51%	+14.49%
Volatility (6M) Calculated over the trailing 6-month period	66.76%	12.77%	+53.99%
Volatility (1Y) Calculated over the trailing 1-year period	112.28%	22.67%	+89.61%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	91.01%	22.39%	+68.62%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	91.01%	22.25%	+68.76%