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Prime Medicine Inc. Common Stock (PRME)
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Company Info

ISIN

US74168J1016

IPO Date

Oct 20, 2022

Highlights

Market Cap

$220.35M

EPS (TTM)

-$1.65

Total Revenue (TTM)

$41.62M

Gross Profit (TTM)

$38.45M

EBITDA (TTM)

-$149.31M

Year Range

$1.12 - $8.27

Target Price

$12.20

Short %

24.67%

Short Ratio

10.09

Share Price Chart


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Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in Prime Medicine Inc. Common Stock, comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.


-100.00%-50.00%0.00%50.00%December2025FebruaryMarchAprilMay
-91.54%
54.40%
PRME (Prime Medicine Inc. Common Stock)
Benchmark (^GSPC)

Returns By Period

Prime Medicine Inc. Common Stock (PRME) returned -55.48% year-to-date (YTD) and -77.27% over the past 12 months.


PRME

YTD

-55.48%

1M

4.00%

6M

-68.29%

1Y

-77.27%

5Y*

N/A

10Y*

N/A

^GSPC (Benchmark)

YTD

-3.77%

1M

3.72%

6M

-5.60%

1Y

8.55%

5Y*

14.11%

10Y*

10.45%

*Annualized

Monthly Returns

The table below presents the monthly returns of PRME, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
2025-4.11%-10.00%-21.03%-13.07%-24.86%-55.48%
2024-28.33%35.91%-18.89%-29.71%31.71%-20.68%9.14%-23.71%-9.58%0.26%-15.21%-11.25%-67.04%
2023-5.38%-6.54%-25.14%11.95%-0.36%6.78%2.87%-12.14%-27.95%-31.97%11.86%22.04%-52.31%
202222.45%-8.66%8.09%20.88%

Risk-Adjusted Performance

Risk-Adjusted Performance Rank

The current rank of PRME is 8, meaning it’s performing worse than 92% of other stocks on our website when it comes to balancing risk and reward. Below is a breakdown of how it compares using common performance measures.


The Risk-Adjusted Performance Rank of PRME is 88
Overall Rank
The Sharpe Ratio Rank of PRME is 1010
Sharpe Ratio Rank
The Sortino Ratio Rank of PRME is 66
Sortino Ratio Rank
The Omega Ratio Rank of PRME is 1010
Omega Ratio Rank
The Calmar Ratio Rank of PRME is 55
Calmar Ratio Rank
The Martin Ratio Rank of PRME is 1212
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

Risk-Adjusted Performance Indicators

The charts below present risk-adjusted performance metrics for Prime Medicine Inc. Common Stock (PRME) and compare them to a chosen benchmark (^GSPC). These indicators evaluate an investment's returns against its associated risks.


The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.

Prime Medicine Inc. Common Stock Sharpe ratios as of May 10, 2025 (values are recalculated daily):

  • 1-Year: -0.83
  • All Time: -0.75

These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns (including price changes and dividends).

The chart below shows the rolling Sharpe ratio of Prime Medicine Inc. Common Stock compared to the selected benchmark. This view highlights how the investment's risk-adjusted performance has changed over time. For deeper analysis or to customize the calculation, use the Sharpe ratio tool.


Rolling 12-month Sharpe Ratio-1.000.001.002.003.00December2025FebruaryMarchAprilMay
-0.83
0.44
PRME (Prime Medicine Inc. Common Stock)
Benchmark (^GSPC)

Dividends

Dividend History


Prime Medicine Inc. Common Stock doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


-100.00%-80.00%-60.00%-40.00%-20.00%0.00%December2025FebruaryMarchAprilMay
-93.84%
-7.88%
PRME (Prime Medicine Inc. Common Stock)
Benchmark (^GSPC)

Worst Drawdowns

The table below displays the maximum drawdowns of the Prime Medicine Inc. Common Stock. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Prime Medicine Inc. Common Stock was 94.55%, occurring on Apr 8, 2025. The portfolio has not yet recovered.

The current Prime Medicine Inc. Common Stock drawdown is 93.84%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-94.55%Nov 2, 2022609Apr 8, 2025
-3.55%Oct 24, 20221Oct 24, 20221Oct 25, 20222

Volatility

Volatility Chart

The current Prime Medicine Inc. Common Stock volatility is 37.11%, representing the average percentage change in the investments's value, either up or down over the past month. The chart below shows the rolling one-month volatility.


0.00%10.00%20.00%30.00%40.00%December2025FebruaryMarchAprilMay
37.11%
6.82%
PRME (Prime Medicine Inc. Common Stock)
Benchmark (^GSPC)

Financials

Financial Performance

The chart below illustrates the trends in the financial health of Prime Medicine Inc. Common Stock over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.


Annual
Quarterly

0.0

Earnings Per Share

The chart presents the Earnings Per Share (EPS) performance of Prime Medicine Inc. Common Stock, comparing actual results with analytics estimates. The company met analyst expectations for EPS in the past quarter.


-0.80-0.60-0.40-0.200.00October2022AprilJulyOctober2023AprilJulyOctober2024AprilJulyOctober
-0.31
-0.31
Actual
Estimate

Valuation

The Valuation section provides an overview of how Prime Medicine Inc. Common Stock is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.


PS Ratio

This chart shows the Price-to-Sales (P/S) ratio for PRME relative to other companies in the Biotechnology industry. Currently, PRME has a P/S ratio of 73.9. This P/S ratio is high relative to other companies in the industry. It could mean the stock is overvalued, or that investors expect strong future growth and profitability.

PB Ratio

The chart illustrates the Price-to-Book (P/B) ratio for PRME in comparison with other companies in the Biotechnology industry. Currently, PRME has a P/B value of 1.4. This P/B ratio is in line with the industry average, suggesting the stock is valued fairly in relation to its book value.

Income Statement



TTM
Revenue

Total Revenue

Cost Of Revenue

Gross Profit

Operating Expenses

Selling, General & Admin Expenses

R&D Expenses

Depreciation And Amortization

Total Operating Expenses

Income

Income Before Tax

Operating Income

EBITDA

EBIT

Earnings From Continuing Operations

Net Income

Income Tax Expense

Other Non-Operating Income (Expenses)

Extraordinary Items

Discontinued Operations

Effect Of Accounting Charges

Non Recurring

Minority Interest

Other Items

Interest Income

Interest Expense

Net Interest Income

Values in undefined except per share items