KPTI vs. QURE
KPTI (Karyopharm Therapeutics Inc.) and QURE (uniQure N.V.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, KPTI returned -23.26%/yr vs 18.67%/yr for QURE. At a 0.31 correlation, their price movements are largely independent.
Performance
KPTI vs. QURE - Performance Comparison
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Returns By Period
In the year-to-date period, KPTI achieves a 1.49% return, which is significantly lower than QURE's 65.90% return. Over the past 10 years, KPTI has underperformed QURE with an annualized return of -23.26%, while QURE has yielded a comparatively higher 18.67% annualized return.
KPTI
- 1D
- -21.45%
- 1M
- -17.18%
- 6M
- 18.38%
- YTD
- 1.49%
- 1Y
- 94.03%
- 3Y*
- -33.06%
- 5Y*
- -44.39%
- 10Y*
- -23.26%
- ALL TIME*
- -24.56%
QURE
- 1D
- -1.37%
- 1M
- -14.24%
- 6M
- 73.82%
- YTD
- 65.90%
- 1Y
- 164.84%
- 3Y*
- 58.24%
- 5Y*
- 7.92%
- 10Y*
- 18.67%
- ALL TIME*
- 7.05%
KPTI vs. QURE - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
KPTI Karyopharm Therapeutics Inc. | 1.49% | -27.45% | -21.82% | -74.56% | -47.12% | -58.46% | -19.25% | 104.59% | -2.40% | 2.13% |
QURE uniQure N.V. | 65.90% | 35.50% | 160.86% | -70.14% | 9.31% | -42.60% | -49.58% | 148.65% | 47.12% | 249.82% |
Correlation
The correlation between KPTI and QURE is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.12 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.20 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.29 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.31 |
Correlation (All Time) Calculated using the full available price history since Feb 5, 2014 | 0.31 |
The correlation between KPTI and QURE shifts across timeframes, from 0.12 (1 year) to 0.31 (10 years), reflecting how their relationship changes across market environments.
Fundamentals
KPTI:
$169.29M
QURE:
$2.70B
KPTI:
-$11.39
QURE:
-$3.51
KPTI:
0.85
QURE:
130.75
KPTI:
$151.12M
QURE:
$18.09M
KPTI:
$145.13M
QURE:
$13.42M
KPTI:
-$93.05M
QURE:
-$164.53M
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Return for Risk
KPTI vs. QURE — Risk / Return Rank
KPTI
QURE
KPTI vs. QURE - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and uniQure N.V. (QURE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| KPTI | QURE | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.41 | ||
| Sortino ratioReturn per unit of downside risk | -1.78 | ||
| Omega ratioGain probability vs. loss probability | 1.23 | 1.55 | -0.32 |
| Calmar ratioReturn relative to maximum drawdown | 1.95 | 1.90 | +0.05 |
| Martin ratioReturn relative to average drawdown | 4.87 | 3.01 | +1.86 |
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Drawdowns
KPTI vs. QURE - Drawdown Comparison
The maximum KPTI drawdown since its inception was -99.50%, roughly equal to the maximum QURE drawdown of -95.40%. Use the drawdown chart below to compare losses from any high point for KPTI and QURE.
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Drawdown Indicators
| KPTI | QURE | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.50% | -95.40% | -4.10% |
Max Drawdown (1Y)Largest decline over 1 year | -48.36% | -87.21% | +38.85% |
Max Drawdown (3Y)Largest decline over 3 years | -86.96% | -87.21% | +0.25% |
Max Drawdown (5Y)Largest decline over 5 years | -98.36% | -90.11% | -8.25% |
Max Drawdown (10Y)Largest decline over 10 years | -99.15% | -95.40% | -3.75% |
Current DrawdownCurrent decline from peak | -98.94% | -51.70% | -47.24% |
Average DrawdownAverage peak-to-trough decline | -75.52% | -56.54% | -18.98% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 19.38% | 55.04% | -35.66% |
Volatility
KPTI vs. QURE - Volatility Comparison
Karyopharm Therapeutics Inc. (KPTI) has a higher volatility of 30.02% compared to uniQure N.V. (QURE) at 17.32%. This indicates that KPTI's price experiences larger fluctuations and is considered to be riskier than QURE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| KPTI | QURE | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 30.02% | 17.32% | +12.70% |
Volatility (6M)Calculated over the trailing 6-month period | 65.02% | 108.22% | -43.20% |
Volatility (1Y)Calculated over the trailing 1-year period | 95.55% | 284.69% | -189.14% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 95.60% | 158.18% | -62.58% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 86.76% | 122.35% | -35.59% |
Dividends
KPTI vs. QURE - Dividend Comparison
Neither KPTI nor QURE has paid dividends to shareholders.
Financials
KPTI vs. QURE - Financials Comparison
This section allows you to compare key financial metrics between Karyopharm Therapeutics Inc. and uniQure N.V.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
KPTI and QURE have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
KPTI has higher volatility (30.02%) compared to QURE (17.32%). In terms of maximum drawdown, KPTI dropped -99.50% vs QURE's -95.40%.
KPTI currently has the higher Sharpe Ratio (0.99 vs 0.58), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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