Highlights
- Market Cap
- $100.14M
- Enterprise Value
- $299.96M
- EPS (TTM)
- -$16.68
- Total Revenue (TTM)
- $146.07M
- Gross Profit (TTM)
- $140.12M
- EBITDA (TTM)
- -$78.65M
- Year Range
- $3.51 - $10.99
- Target Price
- $14.17
- ROA (TTM)
- -166.91%
- ROE (TTM)
- 66.92%
Share Price Chart
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Performance
Performance Chart
The chart shows the growth of an initial investment of $10,000 in Karyopharm Therapeutics Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.
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Returns By Period
Karyopharm Therapeutics Inc. (KPTI) has returned -24.32% so far this year and 48.93% over the past 12 months. Over the last ten years, KPTI has returned -27.27% per year, falling short of the S&P 500 Index benchmark, which averaged 12.16% annually.
Karyopharm Therapeutics Inc.
- 1D
- 5.09%
- 1M
- -40.81%
- YTD
- -24.32%
- 6M
- -14.83%
- 1Y
- 48.93%
- 3Y*
- -54.30%
- 5Y*
- -49.07%
- 10Y*
- -27.27%
Benchmark (S&P 500 Index)
- 1D
- 2.91%
- 1M
- -5.09%
- YTD
- -4.63%
- 6M
- -2.39%
- 1Y
- 16.33%
- 3Y*
- 16.69%
- 5Y*
- 10.18%
- 10Y*
- 12.16%
Monthly Returns
Based on dividend-adjusted daily data since Nov 6, 2013, KPTI's average daily return is +0.03%, while the average monthly return is +0.50%. At this rate, your investment would double in approximately 11.6 years.
Historically, 46% of months were positive and 54% were negative. The best month was Aug 2025 with a return of +86.6%, while the worst month was Jan 2016 at -53.1%. The longest winning streak lasted 5 consecutive months, and the longest losing streak was 6 months.
On a daily basis, KPTI closed higher 48% of trading days. The best single day was Jun 13, 2014 with a return of +93.5%, while the worst single day was Feb 22, 2019 at -43.5%.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | -11.41% | 44.33% | -40.81% | -24.32% | |||||||||
| 2025 | -8.01% | -14.80% | -52.96% | 80.48% | -37.78% | 2.62% | -11.60% | 86.61% | -8.02% | -11.31% | -3.10% | 30.96% | -27.45% |
| 2024 | -13.24% | 54.56% | 30.17% | -31.79% | -5.91% | -10.47% | 13.97% | -23.12% | 9.18% | 19.25% | -14.63% | -19.96% | -21.82% |
| 2023 | -2.94% | -8.48% | 28.81% | -7.97% | -36.87% | -20.80% | 0.56% | -28.89% | 4.69% | -35.07% | -11.49% | 12.34% | -74.56% |
| 2022 | 38.41% | 16.07% | -28.65% | -17.23% | 2.95% | -28.18% | -5.76% | 19.06% | 7.91% | -12.82% | 11.13% | -35.73% | -47.12% |
| 2021 | -1.61% | -9.26% | -23.88% | -11.22% | -0.64% | 11.21% | -19.28% | -30.37% | 0.34% | -6.19% | 27.29% | -7.48% | -58.46% |
Benchmark Metrics
Karyopharm Therapeutics Inc. has an annualized alpha of -10.35%, beta of 1.47, and R² of 0.08 versus S&P 500 Index. Calculated based on daily prices since November 07, 2013.
- This stock participated in 164.87% of S&P 500 Index downside but only -3.39% of its upside — more exposed to losses than it benefited from rallies.
- R² of 0.08 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.
- Alpha
- -10.35%
- Beta
- 1.47
- R²
- 0.08
- Upside Capture
- -3.39%
- Downside Capture
- 164.87%
Return for Risk
Risk / Return Rank
KPTI ranks 59 for risk / return — on par with similar stocks. You're getting a typical balance of risk and reward. Not a standout, but not a red flag either — a reasonable choice if other factors align with your goals.
Return / Risk — by metrics
The table below present risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and compare them to a chosen benchmark (S&P 500 Index).
| KPTI | Benchmark | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 0.50 | 0.90 | -0.40 |
Sortino ratioReturn per unit of downside risk | 1.49 | 1.39 | +0.10 |
Omega ratioGain probability vs. loss probability | 1.17 | 1.21 | -0.05 |
Calmar ratioReturn relative to maximum drawdown | 0.69 | 1.40 | -0.70 |
Martin ratioReturn relative to average drawdown | 1.26 | 6.61 | -5.35 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
Explore KPTI risk-adjusted metrics in detail
Dive deeper into individual metrics with historical trends, benchmark comparisons, and performance across different time periods.
Dividends
Dividend History
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
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Worst Drawdowns
The table below displays the maximum drawdowns of the Karyopharm Therapeutics Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the Karyopharm Therapeutics Inc. was 99.50%, occurring on Apr 1, 2025. The portfolio has not yet recovered.
The current Karyopharm Therapeutics Inc. drawdown is 99.21%.
Depth | Start | To Bottom | Bottom | To Recover | End | Total |
|---|---|---|---|---|---|---|
| -99.5% | Jun 16, 2014 | 2716 | Apr 1, 2025 | — | — | — |
| -43.74% | Mar 7, 2014 | 68 | Jun 12, 2014 | 1 | Jun 13, 2014 | 69 |
| -10.42% | Dec 23, 2013 | 14 | Jan 13, 2014 | 2 | Jan 15, 2014 | 16 |
| -9.08% | Feb 3, 2014 | 3 | Feb 5, 2014 | 5 | Feb 12, 2014 | 8 |
| -8.83% | Mar 5, 2014 | 1 | Mar 5, 2014 | 1 | Mar 6, 2014 | 2 |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
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Financials
Financial Performance
The chart below illustrates the trends in the financial health of Karyopharm Therapeutics Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.
Valuation
The Valuation section provides an overview of how Karyopharm Therapeutics Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.
PS Ratio
This chart shows the Price-to-Sales (P/S) ratio for KPTI relative to other companies in the Biotechnology industry. Currently, KPTI has a P/S ratio of 0.4. This P/S ratio is low compared to the industry average. It may indicate that the stock is undervalued relative to its revenue, or that the market expects slower growth or lower margins.
Income Statement
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