Karyopharm Therapeutics Inc. (KPTI)
Company Info
Highlights
$39.14M
-$11.87
-0.15
$142.13M
$136.64M
-$40.54M
$3.51 - $17.40
$29.25
24.36%
23.12
Share Price Chart
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Performance
Performance Chart
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Returns By Period
Karyopharm Therapeutics Inc. (KPTI) returned -58.60% year-to-date (YTD) and -70.47% over the past 12 months. Over the past 10 years, KPTI returned -36.57% annually, underperforming the S&P 500 benchmark at 10.85%.
KPTI
-58.60%
-37.78%
-66.87%
-70.47%
-64.54%
-56.74%
-36.57%
^GSPC (Benchmark)
0.51%
6.15%
-2.00%
12.92%
12.68%
14.19%
10.85%
Monthly Returns
The table below presents the monthly returns of KPTI, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | -8.01% | -14.80% | -52.96% | 80.48% | -37.78% | -58.60% | |||||||
| 2024 | -13.24% | 54.56% | 30.17% | -31.79% | -5.91% | -10.47% | 13.97% | -23.12% | 9.18% | 19.25% | -14.62% | -19.97% | -21.82% |
| 2023 | -2.94% | -8.48% | 28.81% | -7.97% | -36.87% | -20.80% | 0.56% | -28.89% | 4.69% | -35.07% | -11.49% | 12.34% | -74.56% |
| 2022 | 38.41% | 16.07% | -28.65% | -17.23% | 2.95% | -28.18% | -5.76% | 19.06% | 7.91% | -12.82% | 11.13% | -35.73% | -47.12% |
| 2021 | -1.61% | -9.26% | -23.88% | -11.22% | -0.64% | 11.21% | -19.28% | -30.37% | 0.34% | -6.19% | 27.29% | -7.48% | -58.46% |
| 2020 | -15.75% | 1.18% | 17.56% | 14.78% | -16.15% | 2.43% | -15.26% | -5.23% | -4.01% | 1.51% | 14.64% | -8.89% | -19.25% |
| 2019 | -9.61% | -51.24% | 41.40% | -20.03% | 20.77% | 6.21% | 47.08% | -1.93% | 11.34% | 21.62% | 49.74% | 9.42% | 104.59% |
| 2018 | 23.13% | 24.96% | -9.14% | -2.53% | 42.05% | -8.56% | 4.65% | 18.39% | -19.10% | -38.11% | -1.33% | -9.90% | -2.40% |
| 2017 | 10.11% | 0.19% | 23.82% | -20.40% | -20.55% | 11.45% | -6.74% | 21.09% | 7.44% | -7.01% | 9.60% | -14.21% | 2.13% |
| 2016 | -53.06% | -5.14% | 51.19% | 4.26% | 2.90% | -29.89% | 9.99% | 34.82% | -2.21% | -25.59% | 27.49% | 1.84% | -29.06% |
| 2015 | -29.12% | 2.75% | 12.29% | -11.27% | -0.88% | 1.08% | -24.59% | -32.46% | -24.03% | 26.78% | 40.07% | -29.14% | -64.60% |
| 2014 | 52.31% | 14.98% | -23.04% | -13.14% | -2.16% | 77.33% | -25.48% | 3.78% | -2.94% | 17.57% | 1.95% | -10.63% | 63.31% |
Risk-Adjusted Performance
Risk-Adjusted Performance Rank
The current rank of KPTI is 7, meaning it’s performing worse than 93% of other stocks on our website when it comes to balancing risk and reward. Below is a breakdown of how it compares using common performance measures.
Risk-Adjusted Performance Indicators
The charts below present risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and compare them to a chosen benchmark (^GSPC). These indicators evaluate an investment's returns against its associated risks.
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Dividends
Dividend History
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
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Worst Drawdowns
The table below displays the maximum drawdowns of the Karyopharm Therapeutics Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the Karyopharm Therapeutics Inc. was 99.50%, occurring on Apr 1, 2025. The portfolio has not yet recovered.
The current Karyopharm Therapeutics Inc. drawdown is 99.41%.
Depth | Start | To Bottom | Bottom | To Recover | End | Total |
|---|---|---|---|---|---|---|
| -99.5% | Jun 16, 2014 | 2716 | Apr 1, 2025 | — | — | — |
| -43.74% | Mar 7, 2014 | 68 | Jun 12, 2014 | 1 | Jun 13, 2014 | 69 |
| -10.42% | Dec 23, 2013 | 14 | Jan 13, 2014 | 2 | Jan 15, 2014 | 16 |
| -9.08% | Feb 3, 2014 | 3 | Feb 5, 2014 | 5 | Feb 12, 2014 | 8 |
| -8.83% | Mar 5, 2014 | 1 | Mar 5, 2014 | 1 | Mar 6, 2014 | 2 |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
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Financials
Financial Performance
The chart below illustrates the trends in the financial health of Karyopharm Therapeutics Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.
Earnings Per Share
The chart presents the Earnings Per Share (EPS) performance of Karyopharm Therapeutics Inc., comparing actual results with analytics estimates. The company has exceeded analyst expectations for EPS in the past quarter, achieving a 10.3% positive surprise.
Valuation
The Valuation section provides an overview of how Karyopharm Therapeutics Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.
PEG Ratio
The chart shows the Price/Earnings to Growth (PEG) ratio for KPTI compared to other companies in the Biotechnology industry. KPTI currently has a PEG ratio of -0.2. This PEG ratio is negative, which typically signals that the company's earnings are expected to decline. A negative PEG is not considered meaningful for valuation purposes.
PS Ratio
This chart shows the Price-to-Sales (P/S) ratio for KPTI relative to other companies in the Biotechnology industry. Currently, KPTI has a P/S ratio of 0.3. This P/S ratio is low compared to the industry average. It may indicate that the stock is undervalued relative to its revenue, or that the market expects slower growth or lower margins.
PB Ratio
The chart illustrates the Price-to-Book (P/B) ratio for KPTI in comparison with other companies in the Biotechnology industry. Currently, KPTI has a P/B value of 12.0. This P/B ratio is higher than most companies in the industry. It may suggest the stock is overvalued or that investors expect the company to generate high returns on its assets.
Income Statement
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