QURE vs. ACET

Last updated Apr 2, 2026

Compare and contrast key facts about uniQure N.V. (QURE) and Adicet Bio, Inc. (ACET).

Performance

QURE vs. ACET - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in uniQure N.V. (QURE) and Adicet Bio, Inc. (ACET). The values are adjusted to include any dividend payments, if applicable.

QURE vs. ACET - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
QURE uniQure N.V.	-29.42%	35.50%	160.86%	-70.14%	9.31%	-42.60%	-49.58%	148.65%	48.63%
ACET Adicet Bio, Inc.	-18.29%	-45.30%	-49.10%	-78.86%	-48.89%	24.48%	34.71%	-82.71%	-48.93%

Fundamentals

Market Cap QURE : $971.21M ACET : $47.41M
EPS QURE : -$3.49 ACET : -$19.17
PB Ratio QURE : 4.88 ACET : 0.30
Total Revenue (TTM) QURE : $16.10M ACET : $0.00
Gross Profit (TTM) QURE : $14.41M ACET : $0.00
EBITDA (TTM) QURE : -$144.25M ACET : -$122.11M

Returns By Period

In the year-to-date period, QURE achieves a -29.42% return, which is significantly lower than ACET's -18.29% return.

QURE

• 1D: 3.30%
• 1M: 60.86%
• YTD: -29.42%
• 6M: -69.29%
• 1Y: 70.43%
• 3Y*: -5.70%
• 5Y*: -13.11%
• 10Y*: 2.85%

ACET

• 1D: 1.03%
• 1M: -5.62%
• YTD: -18.29%
• 6M: -47.70%
• 1Y: -41.50%
• 3Y*: -57.89%
• 5Y*: -49.51%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

QURE vs. ACET — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

QURE

QURE Risk / Return Rank: 69
QURE Sharpe Ratio Rank: 50
QURE Sortino Ratio Rank: 90
QURE Omega Ratio Rank: 92
QURE Calmar Ratio Rank: 57
QURE Martin Ratio Rank: 54

ACET

ACET Risk / Return Rank: 20
ACET Sharpe Ratio Rank: 20
ACET Sortino Ratio Rank: 24
ACET Omega Ratio Rank: 24
ACET Calmar Ratio Rank: 17
ACET Martin Ratio Rank: 16

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

QURE vs. ACET - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for uniQure N.V. (QURE) and Adicet Bio, Inc. (ACET). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	QURE	ACET	Difference
Sharpe ratio Return per unit of total volatility	0.26	-0.46	+0.72
Sortino ratio Return per unit of downside risk	2.92	-0.23	+3.15
Omega ratio Gain probability vs. loss probability	1.45	0.97	+0.47
Calmar ratio Return relative to maximum drawdown	0.68	-0.68	+1.36
Martin ratio Return relative to average drawdown	1.32	-1.23	+2.55
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

QURE vs. ACET - Sharpe Ratio Comparison

The current QURE Sharpe Ratio is 0.26, which is higher than the ACET Sharpe Ratio of -0.46. The chart below compares the historical Sharpe Ratios of QURE and ACET, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	QURE	ACET	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.26	-0.46	+0.72
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.09	-0.55	+0.46
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.02	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.01	-0.53	+0.54

Correlation

The correlation between QURE and ACET is 0.29, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

QURE vs. ACET - Dividend Comparison

Neither QURE nor ACET has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

QURE vs. ACET - Drawdown Comparison

The maximum QURE drawdown since its inception was -95.40%, roughly equal to the maximum ACET drawdown of -99.74%. Use the drawdown chart below to compare losses from any high point for QURE and ACET.

Drawdown Indicators

	QURE	ACET	Difference
Max Drawdown Largest peak-to-trough decline	-95.40%	-99.74%	+4.34%
Max Drawdown (1Y) Largest decline over 1 year	-87.21%	-63.28%	-23.93%
Max Drawdown (5Y) Largest decline over 5 years	-90.11%	-98.20%	+8.09%
Max Drawdown (10Y) Largest decline over 10 years	-95.40%	—	—
Current Drawdown Current decline from peak	-79.45%	-99.71%	+20.26%
Average Drawdown Average peak-to-trough decline	-56.34%	-85.02%	+28.68%
Ulcer Index Depth and duration of drawdowns from previous peaks	44.96%	34.89%	+10.07%

Volatility

QURE vs. ACET - Volatility Comparison

uniQure N.V. (QURE) has a higher volatility of 44.88% compared to Adicet Bio, Inc. (ACET) at 18.73%. This indicates that QURE's price experiences larger fluctuations and is considered to be riskier than ACET based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	QURE	ACET	Difference
Volatility (1M) Calculated over the trailing 1-month period	44.88%	18.73%	+26.15%
Volatility (6M) Calculated over the trailing 6-month period	113.48%	53.99%	+59.49%
Volatility (1Y) Calculated over the trailing 1-year period	276.62%	90.61%	+186.01%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	153.21%	90.36%	+62.85%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	119.51%	94.11%	+25.40%

Financials