KPTI vs. ARCT
KPTI (Karyopharm Therapeutics Inc.) and ARCT (Arcturus Therapeutics Holdings Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, KPTI returned -56.62%/yr vs -28.72%/yr for ARCT. Their 0.33 correlation means their historical movements had little consistent relationship.
Performance
KPTI vs. ARCT - Performance Comparison
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Returns By Period
In the year-to-date period, KPTI achieves a -73.91% return, which is significantly lower than ARCT's -6.04% return.
KPTI
- 1D
- -72.61%
- 1M
- -80.00%
- 6M
- -70.55%
- YTD
- -73.91%
- 1Y
- -51.15%
- 3Y*
- -58.57%
- 5Y*
- -56.62%
- 10Y*
- -32.96%
- ALL TIME*
- -32.15%
ARCT
- 1D
- -2.70%
- 1M
- -20.88%
- 6M
- -22.89%
- YTD
- -6.04%
- 1Y
- -53.17%
- 3Y*
- -45.16%
- 5Y*
- -28.72%
- 10Y*
- —
- ALL TIME*
- -16.73%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $2.42M | $3.57M | $3.41M | |
| $12.61M | $7.85M | $5.63M |
KPTI vs. ARCT - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | |
|---|---|---|---|---|---|---|---|
KPTI Karyopharm Therapeutics Inc. | -73.91% | -27.45% | -21.82% | -74.56% | -47.12% | -58.46% | -25.07% |
ARCT Arcturus Therapeutics Holdings Inc. | -6.04% | -63.88% | -46.18% | 85.91% | -54.17% | -14.68% | 138.09% |
Correlation
The correlation between KPTI and ARCT is 0.17, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.17 |
Correlation (3Y) Balances recent behavior with more history. | 0.26 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.34 |
Correlation (All Time) Calculated using the full available price history since Apr 16, 2020 | 0.33 |
The correlation between KPTI and ARCT shifts across timeframes, from 0.17 (1 year) to 0.34 (5 years), reflecting how their relationship changes across market environments.
Fundamentals
KPTI:
$43.51M
ARCT:
$163.72M
KPTI:
-$11.39
ARCT:
-$1.80
KPTI:
0.22
ARCT:
3.40
KPTI:
$151.12M
ARCT:
$46.80M
KPTI:
$145.13M
ARCT:
$40.72M
KPTI:
-$93.05M
ARCT:
-$84.61M
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Return for Risk
KPTI vs. ARCT — Risk / Return Rank
KPTI
ARCT
KPTI vs. ARCT - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and Arcturus Therapeutics Holdings Inc. (ARCT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| KPTI | ARCT | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +0.16 | ||
| Sortino ratioReturn per unit of downside risk | +0.75 | ||
| Omega ratioGain probability vs. loss probability | 1.05 | 0.94 | +0.12 |
| Calmar ratioReturn relative to maximum drawdown | -0.61 | -0.70 | +0.09 |
| Martin ratioReturn relative to average drawdown | -2.42 | -0.89 | -1.54 |
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Drawdowns
KPTI vs. ARCT - Drawdown Comparison
The maximum KPTI drawdown since its inception was -99.73%, roughly equal to the maximum ARCT drawdown of -95.53%. Use the drawdown chart below to compare losses from any high point for KPTI and ARCT.
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Drawdown Indicators
| KPTI | ARCT | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.73% | -95.53% | -4.20% |
Max Drawdown (1Y)Largest decline over 1 year | -82.01% | -76.12% | -5.89% |
Max Drawdown (3Y)Largest decline over 3 years | -92.73% | -87.54% | -5.19% |
Max Drawdown (5Y)Largest decline over 5 years | -99.11% | -90.34% | -8.77% |
Max Drawdown (10Y)Largest decline over 10 years | -99.54% | — | — |
Current DrawdownCurrent decline from peak | -99.73% | -95.34% | -4.39% |
Average DrawdownAverage peak-to-trough decline | -75.59% | -73.48% | -2.11% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 20.49% | 59.69% | -39.20% |
Volatility
KPTI vs. ARCT - Volatility Comparison
Karyopharm Therapeutics Inc. (KPTI) has a higher volatility of 131.26% compared to Arcturus Therapeutics Holdings Inc. (ARCT) at 13.40%. This indicates that KPTI's price experiences larger fluctuations and is considered to be riskier than ARCT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| KPTI | ARCT | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 131.26% | 13.40% | +117.86% |
Volatility (6M)Calculated over the trailing 6-month period | 144.90% | 39.07% | +105.83% |
Volatility (1Y)Calculated over the trailing 1-year period | 117.57% | 90.94% | +26.63% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 101.03% | 91.54% | +9.49% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 89.78% | 101.26% | -11.48% |
Dividends
KPTI vs. ARCT - Dividend Comparison
Neither KPTI nor ARCT has paid dividends to shareholders.
Financials
KPTI vs. ARCT - Financials Comparison
This section allows you to compare key financial metrics between Karyopharm Therapeutics Inc. and Arcturus Therapeutics Holdings Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
KPTI and ARCT have a correlation of 0.17, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
KPTI has higher volatility (131.26%) compared to ARCT (13.40%). In terms of maximum drawdown, KPTI dropped -99.73% vs ARCT's -95.53%.
KPTI currently has the higher Sharpe Ratio (-0.42 vs -0.58), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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