KPTI vs. META
KPTI (Karyopharm Therapeutics Inc.) and META (Meta Platforms, Inc.) are both stocks. KPTI operates in Biotechnology (Healthcare), while META operates in Internet Content & Information (Communication Services). Over the past 10 years, KPTI returned -23.93%/yr vs 18.15%/yr for META. At a 0.25 correlation, their price movements are largely independent.
Performance
KPTI vs. META - Performance Comparison
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Returns By Period
In the year-to-date period, KPTI achieves a 22.28% return, which is significantly higher than META's -5.54% return. Over the past 10 years, KPTI has underperformed META with an annualized return of -23.93%, while META has yielded a comparatively higher 18.15% annualized return.
KPTI
- 1D
- -2.49%
- 1M
- -3.23%
- YTD
- 22.28%
- 6M
- 64.84%
- 1Y
- 111.76%
- 3Y*
- -35.73%
- 5Y*
- -41.77%
- 10Y*
- -23.93%
META
- 1D
- 4.24%
- 1M
- 2.06%
- YTD
- -5.54%
- 6M
- -2.44%
- 1Y
- -6.29%
- 3Y*
- 32.06%
- 5Y*
- 13.70%
- 10Y*
- 18.15%
KPTI vs. META - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
KPTI Karyopharm Therapeutics Inc. | 22.28% | -27.45% | -21.82% | -74.56% | -47.12% | -58.46% | -19.25% | 104.59% | -2.40% | 2.13% |
META Meta Platforms, Inc. | -5.54% | 13.09% | 66.05% | 194.13% | -64.22% | 23.13% | 33.09% | 56.57% | -25.71% | 53.38% |
Correlation
The correlation between KPTI and META is 0.14, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.14 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.09 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.20 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.24 |
Correlation (All Time) Calculated using the full available price history since Nov 7, 2013 | 0.25 |
The correlation between KPTI and META shifts across timeframes, from 0.09 (3 years) to 0.25 (all time), reflecting how their relationship changes across market environments.
Fundamentals
KPTI:
$222.44M
META:
$1.60T
KPTI:
-$13.00
META:
$27.47
KPTI:
0.89
META:
7.45
KPTI:
$151.12M
META:
$214.96B
KPTI:
$145.13M
META:
$176.14B
KPTI:
-$93.05M
META:
$106.31B
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Return for Risk
KPTI vs. META — Risk / Return Rank
KPTI
META
KPTI vs. META - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and Meta Platforms, Inc. (META). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| KPTI | META | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.37 | ||
| Sortino ratioReturn per unit of downside risk | +2.19 | ||
| Omega ratioGain probability vs. loss probability | 1.25 | 1.00 | +0.25 |
| Calmar ratioReturn relative to maximum drawdown | 2.32 | -0.19 | +2.51 |
| Martin ratioReturn relative to average drawdown | 5.76 | -0.41 | +6.16 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| KPTI | META | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 1.20 | -0.18 | +1.37 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.44 | 0.31 | -0.75 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | -0.28 | 0.47 | -0.75 |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.26 | 0.56 | -0.82 |
Drawdowns
KPTI vs. META - Drawdown Comparison
The maximum KPTI drawdown since its inception was -99.50%, which is greater than META's maximum drawdown of -76.74%. Use the drawdown chart below to compare losses from any high point for KPTI and META.
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Drawdown Indicators
| KPTI | META | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.50% | -76.74% | -22.76% |
Max Drawdown (1Y)Largest decline over 1 year | -48.36% | -33.30% | -15.06% |
Max Drawdown (3Y)Largest decline over 3 years | -90.08% | -34.15% | -55.93% |
Max Drawdown (5Y)Largest decline over 5 years | -98.36% | -76.74% | -21.62% |
Max Drawdown (10Y)Largest decline over 10 years | -99.15% | -76.74% | -22.41% |
Current DrawdownCurrent decline from peak | -98.73% | -20.96% | -77.77% |
Average DrawdownAverage peak-to-trough decline | -75.26% | -15.25% | -60.01% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 19.49% | 15.47% | +4.02% |
Volatility
KPTI vs. META - Volatility Comparison
Karyopharm Therapeutics Inc. (KPTI) has a higher volatility of 24.41% compared to Meta Platforms, Inc. (META) at 8.84%. This indicates that KPTI's price experiences larger fluctuations and is considered to be riskier than META based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| KPTI | META | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 24.41% | 8.84% | +15.57% |
Volatility (6M)Calculated over the trailing 6-month period | 62.85% | 26.58% | +36.27% |
Volatility (1Y)Calculated over the trailing 1-year period | 94.09% | 35.23% | +58.86% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 94.91% | 43.99% | +50.92% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 86.48% | 38.64% | +47.84% |
Dividends
KPTI vs. META - Dividend Comparison
KPTI has not paid dividends to shareholders, while META's dividend yield for the trailing twelve months is around 0.34%.
| Position | TTM | 2025 | 2024 |
|---|---|---|---|
KPTI Karyopharm Therapeutics Inc. | 0.00% | 0.00% | 0.00% |
META Meta Platforms, Inc. | 0.34% | 0.32% | 0.34% |
Financials
KPTI vs. META - Financials Comparison
This section allows you to compare key financial metrics between Karyopharm Therapeutics Inc. and Meta Platforms, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
KPTI vs. META - Profitability Comparison
KPTI - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported a gross profit of 33.72M and revenue of 35.07M. Therefore, the gross margin over that period was 96.2%.
META - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Meta Platforms, Inc. reported a gross profit of 46.09B and revenue of 56.31B. Therefore, the gross margin over that period was 81.9%.
KPTI - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported an operating income of -26.76M and revenue of 35.07M, resulting in an operating margin of -76.3%.
META - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Meta Platforms, Inc. reported an operating income of 22.87B and revenue of 56.31B, resulting in an operating margin of 40.6%.
KPTI - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported a net income of -22.39M and revenue of 35.07M, resulting in a net margin of -63.9%.
META - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Meta Platforms, Inc. reported a net income of 26.77B and revenue of 56.31B, resulting in a net margin of 47.5%.
Frequently Asked Questions
KPTI and META have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
KPTI has higher volatility (24.41%) compared to META (8.84%). In terms of maximum drawdown, KPTI dropped -99.50% vs META's -76.74%.
KPTI currently has the higher Sharpe Ratio (1.20 vs -0.18), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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