KPTI vs. OKLO

Last updated Jun 3, 2026

KPTI (Karyopharm Therapeutics Inc.) and OKLO (Oklo Inc.) are both stocks. KPTI operates in Biotechnology (Healthcare), while OKLO operates in Utilities - Regulated Electric (Utilities). Over the past 3 years, KPTI returned -35.19%/yr vs 90.22%/yr for OKLO. At a 0.09 correlation, their price movements are largely independent.

Performance

KPTI vs. OKLO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Karyopharm Therapeutics Inc. (KPTI) and Oklo Inc. (OKLO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, KPTI achieves a 25.41% return, which is significantly higher than OKLO's 2.38% return.

KPTI

• 1D: -6.01%
• 1M: 5.25%
• YTD: 25.41%
• 6M: 72.20%
• 1Y: 124.03%
• 3Y*: -35.19%
• 5Y*: -41.84%
• 10Y*: -23.74%

OKLO

• 1D: 9.84%
• 1M: 4.36%
• YTD: 2.38%
• 6M: -20.00%
• 1Y: 40.10%
• 3Y*: 90.22%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

KPTI vs. OKLO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
KPTI Karyopharm Therapeutics Inc.	25.41%	-27.45%	-21.82%	-74.56%	-47.12%	-36.77%
OKLO Oklo Inc.	2.38%	238.01%	101.04%	6.45%	0.71%	-1.30%

Correlation

The correlation between KPTI and OKLO is 0.13, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.13
Correlation (3Y) Calculated over the trailing 3-year period	0.13
Correlation (All Time) Calculated using the full available price history since Jul 9, 2021	0.09

Fundamentals

Market Cap KPTI : $228.12M OKLO : $12.51B
EPS KPTI : -$13.00 OKLO : -$0.85
Total Revenue (TTM) KPTI : $151.12M OKLO : $0.00
Gross Profit (TTM) KPTI : $145.13M OKLO : -$149.00K
EBITDA (TTM) KPTI : -$93.05M OKLO : -$172.42M

Return for Risk

KPTI vs. OKLO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

KPTI

KPTI Risk / Return Rank: 77
KPTI Sharpe Ratio Rank: 78
KPTI Sortino Ratio Rank: 78
KPTI Omega Ratio Rank: 74
KPTI Calmar Ratio Rank: 78
KPTI Martin Ratio Rank: 78

OKLO

OKLO Risk / Return Rank: 55
OKLO Sharpe Ratio Rank: 53
OKLO Sortino Ratio Rank: 62
OKLO Omega Ratio Rank: 56
OKLO Calmar Ratio Rank: 53
OKLO Martin Ratio Rank: 50

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

KPTI vs. OKLO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and Oklo Inc. (OKLO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	KPTI	OKLO	Difference
Sharpe ratio Return per unit of total volatility	1.33	0.38	+0.94
Sortino ratio Return per unit of downside risk	2.29	1.36	+0.93
Omega ratio Gain probability vs. loss probability	1.26	1.15	+0.11
Calmar ratio Return relative to maximum drawdown	2.48	0.53	+1.94
Martin ratio Return relative to average drawdown	6.15	0.89	+5.26
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

KPTI vs. OKLO - Sharpe Ratio Comparison

The current KPTI Sharpe Ratio is 1.33, which is higher than the OKLO Sharpe Ratio of 0.38. The chart below compares the historical Sharpe Ratios of KPTI and OKLO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	KPTI	OKLO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.33	0.38	+0.94
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.44	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.28	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.26	0.59	-0.85

Drawdowns

KPTI vs. OKLO - Drawdown Comparison

The maximum KPTI drawdown since its inception was -99.50%, which is greater than OKLO's maximum drawdown of -73.83%. Use the drawdown chart below to compare losses from any high point for KPTI and OKLO.

Drawdown Indicators

	KPTI	OKLO	Difference
Max Drawdown Largest peak-to-trough decline	-99.50%	-73.83%	-25.67%
Max Drawdown (1Y) Largest decline over 1 year	-48.36%	-73.83%	+25.47%
Max Drawdown (3Y) Largest decline over 3 years	-90.08%	-73.83%	-16.25%
Max Drawdown (5Y) Largest decline over 5 years	-98.36%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-99.15%	—	—
Current Drawdown Current decline from peak	-98.69%	-57.81%	-40.88%
Average Drawdown Average peak-to-trough decline	-75.25%	-17.83%	-57.42%
Ulcer Index Depth and duration of drawdowns from previous peaks	19.48%	44.26%	-24.78%

Volatility

KPTI vs. OKLO - Volatility Comparison

The current volatility for Karyopharm Therapeutics Inc. (KPTI) is 25.00%, while Oklo Inc. (OKLO) has a volatility of 29.92%. This indicates that KPTI experiences smaller price fluctuations and is considered to be less risky than OKLO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	KPTI	OKLO	Difference
Volatility (1M) Calculated over the trailing 1-month period	25.00%	29.92%	-4.92%
Volatility (6M) Calculated over the trailing 6-month period	62.82%	69.55%	-6.73%
Volatility (1Y) Calculated over the trailing 1-year period	94.08%	105.09%	-11.01%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	94.90%	85.77%	+9.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	86.49%	85.77%	+0.72%

Dividends

KPTI vs. OKLO - Dividend Comparison

Neither KPTI nor OKLO has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both KPTI and OKLO in my portfolio?

KPTI and OKLO have a correlation of 0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, KPTI or OKLO?

OKLO has higher volatility (29.92%) compared to KPTI (25.00%). In terms of maximum drawdown, KPTI dropped -99.50% vs OKLO's -73.83%.

Which has better risk-adjusted returns?

KPTI currently has the higher Sharpe Ratio (1.33 vs 0.38), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.