SPDR S&P Health Care Equipment ETF (XHE) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with XHE. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to XHE
XHE charges 0.35% annually. There are 7 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | XHE vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | XHE vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | XHE vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | XHE vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | XHE vs GSKH |
Best Risk-Adjusted Alternatives to XHE
XHE has a PortfoliosLab risk / return rank of 18. There are 51 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | XHE vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | XHE vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | XHE vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | XHE vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | XHE vs IBRN |
Top Performing XHE Alternatives (YTD)
XHE is at 0.00% YTD. There are 56 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | XHE vs ARKG | |
| AdvisorShares Psychedelics ETF | 38.09% | 44.37M | Sep 2021 | XHE vs PSIL | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | XHE vs BBC | |
| Roundhill UNH WeeklyPay ETF | 32.77% | 6.01M | Dec 2025 | XHE vs UNHW | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | XHE vs SBIO |
Lowest Volatility Alternatives to XHE
XHE has 22.38% 1-year volatility. There are 43 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | XHE vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | XHE vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | XHE vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.89% | 16.78M | Jul 2025 | XHE vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.77% | 982.35K | Apr 2026 | XHE vs MHIP |
Lowest Drawdown Alternatives to XHE
XHE has a 1-year max drawdown of -18.29%. There are 46 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | XHE vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | XHE vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | XHE vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | XHE vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | XHE vs IHE |
Other ETFs from State Street
The 10 most viewed State Street ETFs shown here include SPY, GLD, XLK and span 10 categories. AUM among these funds goes as high as $783B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| State Street SPDR S&P 500 ETF | S&P 500 | 66 | 10.45% | 783.21B | Jan 1993 | XHE vs SPY | |
| SPDR Gold Shares | Gold, Precious Metals | 22 | -7.36% | 132.10B | Nov 2004 | XHE vs GLD | |
| State Street Technology Select Sector SPDR ETF | Technology Equities | 63 | 26.22% | 120.59B | Dec 1998 | XHE vs XLK | |
| State Street SPDR Portfolio S&P 500 Growth ETF | S&P 500, Large Cap Growth Equities | 48 | 10.97% | 52.75B | Sep 2000 | XHE vs SPYG | |
| State Street SPDR Portfolio S&P 500 High Dividend ... | S&P 500, Dividend | 54 | 14.99% | 7.40B | Oct 2015 | XHE vs SPYD | |
| State Street Energy Select Sector SPDR ETF | Energy Equities | 50 | 28.66% | 36.33B | Dec 1998 | XHE vs XLE | |
| State Street SPDR Portfolio S&P 500 ETF | S&P 500 | 66 | 10.50% | 158.31B | Nov 2005 | XHE vs SPYM | |
| SPDR Gold MiniShares Trust | Gold, Precious Metals | 23 | -7.26% | 27.70B | Jun 2018 | XHE vs GLDM | |
| State Street Utilities Select Sector SPDR ETF | Utilities Equities | 31 | 8.54% | 23.51B | Dec 1998 | XHE vs XLU | |
| SPDR Bloomberg 1-3 Month T-Bill ETF | Government Bonds, Ultrashort Bond | 100 | 1.88% | 46.75B | May 2007 | XHE vs BIL |
Often Compared With XHE
Investors most often compare XHE with IHI, MDEV, HTEC. These 20 comparison targets span 6 categories, based on PortfoliosLab usage data.
Compare XHE with Any Fund or Stock
Compare XHE with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair XHE with funds that move differently
SPDR S&P Health Care Equipment ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to XHE.
Explore XHE Diversifiers