Invesco S&P 500 Equal Weight Health Care ETF (RSPH) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with RSPH. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to RSPH
RSPH charges 0.40% annually. There are 16 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | RSPH vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | RSPH vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | RSPH vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | RSPH vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | RSPH vs GSKH |
Best Risk-Adjusted Alternatives to RSPH
RSPH has a PortfoliosLab risk / return rank of 39. There are 42 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | RSPH vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | RSPH vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | RSPH vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | RSPH vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | RSPH vs IBRN |
Top Performing RSPH Alternatives (YTD)
RSPH is at 7.48% YTD. There are 32 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | RSPH vs ARKG | |
| AdvisorShares Psychedelics ETF | 35.29% | 44.37M | Sep 2021 | RSPH vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 34.33% | 6.01M | Dec 2025 | RSPH vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | RSPH vs BBC | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | RSPH vs SBIO |
Lowest Volatility Alternatives to RSPH
RSPH has 16.26% 1-year volatility. There are 13 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | RSPH vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | RSPH vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | RSPH vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.87% | 16.78M | Jul 2025 | RSPH vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.73% | 982.35K | Apr 2026 | RSPH vs MHIP |
Lowest Drawdown Alternatives to RSPH
RSPH has a 1-year max drawdown of -10.87%. There are 21 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | RSPH vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | RSPH vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | RSPH vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | RSPH vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | RSPH vs IHE |
Other ETFs from Invesco
The 10 most viewed Invesco ETFs shown here include QQQ, SPMO, QQQM and span 12 categories. AUM among these funds goes as high as $481B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Invesco QQQ ETF | Nasdaq-100 | 58 | 16.13% | 481.14B | Mar 1999 | RSPH vs QQQ | |
| Invesco S&P 500 Momentum ETF | Momentum, S&P 500 | 62 | 26.03% | 22.01B | Oct 2015 | RSPH vs SPMO | |
| Invesco NASDAQ 100 ETF | Nasdaq-100 | 59 | 16.16% | 100.59B | Oct 2020 | RSPH vs QQQM | |
| Invesco S&P 500 Equal Weight ETF | S&P 500, Equal Weight | 58 | 12.75% | 96.24B | Apr 2003 | RSPH vs RSP | |
| Invesco PHLX Semiconductor ETF | Semiconductors, Technology Equities | 92 | 74.43% | 2.58B | Jun 2021 | RSPH vs SOXQ | |
| Invesco S&P 500 Top 50 ETF | S&P 500 | 40 | 3.75% | 10.85B | May 2005 | RSPH vs XLG | |
| Invesco S&P 500 Quality ETF | S&P 500, Large Cap Blend Equities | 65 | 16.39% | 20.11B | Dec 2005 | RSPH vs SPHQ | |
| Invesco S&P 500® High Dividend Low Volatility ETF | Dividend, S&P 500, Large Cap Value Equities | 37 | 11.46% | 3.29B | Oct 2012 | RSPH vs SPHD | |
| Invesco S&P MidCap Momentum ETF | Momentum, Mid Cap Growth Equities | 50 | 14.98% | 7.45B | Mar 2005 | RSPH vs XMMO | |
| Invesco Aerospace & Defense ETF | Aerospace & Defense, Industrials Equities | 35 | 9.54% | 8.22B | Oct 2005 | RSPH vs PPA |
Often Compared With RSPH
Investors most often compare RSPH with IXJ, MEDI, SPY. These 20 comparison targets span 6 categories, based on PortfoliosLab usage data.
Compare RSPH with Any Fund or Stock
Compare RSPH with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair RSPH with funds that move differently
Invesco S&P 500 Equal Weight Health Care ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to RSPH.
Explore RSPH Diversifiers