Horizon Kinetics Medical ETF (MEDX) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with MEDX. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to MEDX
MEDX charges 0.85% annually. There are 57 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | MEDX vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | MEDX vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | MEDX vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | MEDX vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | MEDX vs GSKH |
Best Risk-Adjusted Alternatives to MEDX
MEDX has a PortfoliosLab risk / return rank of 59. There are 29 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | MEDX vs BBC | |
| ALPS Medical Breakthroughs ETF | 94 | 213.08M | Dec 2014 | MEDX vs SBIO | |
| First Trust Nasdaq Pharmaceuticals ETF | 94 | 36.36M | Sep 2016 | MEDX vs FTXH | |
| iShares U.S. Pharmaceuticals ETF | 93 | 1.34B | May 2006 | MEDX vs IHE | |
| SPDR S&P Biotech ETF | 93 | 11.10B | Feb 2006 | MEDX vs XBI |
Top Performing MEDX Alternatives (YTD)
MEDX is at 6.55% YTD. There are 39 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 41.35%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 41.35% | 44.37M | Sep 2021 | MEDX vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 38.38% | 1.31B | Oct 2014 | MEDX vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 31.46% | 6.01M | Dec 2025 | MEDX vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 29.44% | 57.56M | Dec 2014 | MEDX vs BBC | |
| SPDR S&P Health Care Services ETF | 26.76% | 204.10M | Sep 2011 | MEDX vs XHS |
Lowest Volatility Alternatives to MEDX
MEDX has 18.98% 1-year volatility. There are 29 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | MEDX vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | MEDX vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.62% | 10.11M | Jun 2007 | MEDX vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.06% | 16.78M | Jul 2025 | MEDX vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.54% | 982.35K | Apr 2026 | MEDX vs MHIP |
Lowest Drawdown Alternatives to MEDX
MEDX has a 1-year max drawdown of -10.54%. There are 15 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | MEDX vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | MEDX vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | MEDX vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | MEDX vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | MEDX vs IHE |
Other ETFs from Horizon
The 10 most viewed Horizon ETFs shown here include BCDF, NVIR, BENJ and span 13 categories. AUM among these funds goes as high as $411M.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Horizon Kinetics Blockchain Development ETF | Cryptocurrency | 13 | 4.63% | 22.57M | Aug 2022 | MEDX vs BCDF | |
| Horizon Kinetics Energy Remediation ETF | Energy Equities | 65 | 18.96% | 5.75M | Feb 2023 | MEDX vs NVIR | |
| Horizon Landmark ETF | Ultrashort Bond | 98 | 1.91% | 210.01M | Jan 2025 | MEDX vs BENJ | |
| Horizon International Managed Risk ETF | Tactical Allocation | — | 17.47% | 410.55M | Dec 2025 | MEDX vs SFTX | |
| Horizon Kinetics Japan Owner Operator ETF | Japan Equities, Asia Pacific Equities | 6 | -5.52% | — | May 2025 | MEDX vs JAPN | |
| Horizon Expedition Plus ETF | Derivative Income | 47 | 9.55% | 133.99M | Jan 2025 | MEDX vs HBTA | |
| Horizon NASDAQ-100 Defined Risk ETF | Equity Hedged, Nasdaq-100 | 45 | 10.23% | 79.22M | Jul 2025 | MEDX vs QGRD | |
| Horizon Digital Frontier ETF | Technology Equities | 30 | 10.06% | 98.39M | Jul 2025 | MEDX vs YNOT | |
| Horizon Core Equity ETF | Large Cap Blend Equities, Actively Managed | 65 | 9.93% | — | Jun 2025 | MEDX vs STOX | |
| Horizon Small/Mid Cap Core Equity ETF | Mid Cap Blend Equities | — | 20.19% | 57.59M | Dec 2025 | MEDX vs SMOX |
Often Compared With MEDX
Investors most often compare MEDX with MEDI, IHI, DIVN. These 20 comparison targets span 10 categories, based on PortfoliosLab usage data.
Compare MEDX with Any Fund or Stock
Compare MEDX with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair MEDX with funds that move differently
Horizon Kinetics Medical ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to MEDX.
Explore MEDX Diversifiers