Global X Genomics & Biotechnology ETF (GNOM) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with GNOM. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to GNOM
GNOM charges 0.50% annually. There are 25 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | GNOM vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | GNOM vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | GNOM vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | GNOM vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | GNOM vs GSKH |
Best Risk-Adjusted Alternatives to GNOM
GNOM has a PortfoliosLab risk / return rank of 77. There are 19 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | GNOM vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | GNOM vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | GNOM vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | GNOM vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | GNOM vs IBRN |
Top Performing GNOM Alternatives (YTD)
GNOM is at 22.46% YTD. There are 10 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | GNOM vs ARKG | |
| AdvisorShares Psychedelics ETF | 35.29% | 44.37M | Sep 2021 | GNOM vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 34.33% | 6.01M | Dec 2025 | GNOM vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | GNOM vs BBC | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | GNOM vs SBIO |
Lowest Volatility Alternatives to GNOM
GNOM has 27.54% 1-year volatility. There are 59 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | GNOM vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | GNOM vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | GNOM vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.87% | 16.78M | Jul 2025 | GNOM vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.73% | 982.35K | Apr 2026 | GNOM vs MHIP |
Lowest Drawdown Alternatives to GNOM
GNOM has a 1-year max drawdown of -18.17%. There are 45 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | GNOM vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | GNOM vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | GNOM vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | GNOM vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | GNOM vs IHE |
Other ETFs from Global X
The 10 most viewed Global X ETFs shown here include QYLD, SHLD, AIQ and span 12 categories. AUM among these funds goes as high as $14B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Global X NASDAQ 100 Covered Call ETF | Nasdaq-100, Derivative Income | 88 | 9.09% | 8.37B | Dec 2013 | GNOM vs QYLD | |
| Global X Defense Tech ETF | Aerospace & Defense | 10 | -6.37% | 6.91B | Sep 2023 | GNOM vs SHLD | |
| Global X Artificial Intelligence & Technology ETF | Technology Equities | 56 | 20.53% | 10.08B | May 2018 | GNOM vs AIQ | |
| Global X Uranium ETF | Uranium | 15 | -4.70% | 5.92B | Nov 2010 | GNOM vs URA | |
| Global X Copper Miners ETF | Copper | 54 | 3.92% | 6.98B | Apr 2010 | GNOM vs COPX | |
| Global X Robotics & Artificial Intelligence Themat... | Robotics, Technology Equities | 18 | -0.94% | 3.44B | Sep 2016 | GNOM vs BOTZ | |
| Global X Silver Miners ETF | Silver, Precious Metals | 31 | -10.96% | 4.14B | Apr 2010 | GNOM vs SIL | |
| Global X S&P 500 Covered Call ETF | Derivative Income, S&P 500 | 89 | 6.88% | 3.22B | Jun 2013 | GNOM vs XYLD | |
| Global X Data Center & Digital Infrastructure ETF | REIT | 84 | 35.04% | 2.25B | Oct 2020 | GNOM vs DTCR | |
| Global X US Infrastructure Development ETF | Industrials Equities | 50 | 17.87% | 14.01B | Mar 2017 | GNOM vs PAVE |
Often Compared With GNOM
Investors most often compare GNOM with IDNA, IBB, TMQ. These 20 comparison targets span 6 categories, based on PortfoliosLab usage data.
Compare GNOM with Any Fund or Stock
Compare GNOM with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair GNOM with funds that move differently
Global X Genomics & Biotechnology ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to GNOM.
Explore GNOM Diversifiers