NBIX vs. ISRG
NBIX (Neurocrine Biosciences, Inc.) and ISRG (Intuitive Surgical, Inc.) are both stocks. Both are in the Healthcare sector — NBIX in Drug Manufacturers - Specialty & Generic, ISRG in Medical Instruments & Supplies. Over the past 10 years, NBIX returned 13.16%/yr vs 19.09%/yr for ISRG. At a 0.30 correlation, their price movements are largely independent.
Performance
NBIX vs. ISRG - Performance Comparison
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Returns By Period
In the year-to-date period, NBIX achieves a 12.64% return, which is significantly higher than ISRG's -27.42% return. Over the past 10 years, NBIX has underperformed ISRG with an annualized return of 13.16%, while ISRG has yielded a comparatively higher 19.09% annualized return.
NBIX
- 1D
- -1.81%
- 1M
- -0.97%
- YTD
- 12.64%
- 6M
- 4.55%
- 1Y
- 27.80%
- 3Y*
- 18.64%
- 5Y*
- 10.13%
- 10Y*
- 13.16%
ISRG
- 1D
- -0.45%
- 1M
- -4.91%
- YTD
- -27.42%
- 6M
- -24.20%
- 1Y
- -19.87%
- 3Y*
- 9.23%
- 5Y*
- 7.37%
- 10Y*
- 19.09%
NBIX vs. ISRG - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
NBIX Neurocrine Biosciences, Inc. | 12.64% | 3.90% | 3.60% | 10.31% | 40.24% | -11.14% | -10.83% | 50.53% | -7.96% | 100.49% |
ISRG Intuitive Surgical, Inc. | -27.42% | 8.51% | 54.72% | 27.14% | -26.15% | 31.76% | 38.39% | 23.43% | 31.23% | 72.64% |
Correlation
The correlation between NBIX and ISRG is 0.35, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.35 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.30 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.30 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.34 |
Correlation (All Time) Calculated using the full available price history since Jun 16, 2000 | 0.30 |
Fundamentals
NBIX:
$16.52B
ISRG:
$147.90B
NBIX:
$6.53
ISRG:
$8.24
NBIX:
24.46
ISRG:
49.88
NBIX:
0.48
ISRG:
3.05
NBIX:
5.27
ISRG:
14.04
NBIX:
4.85
ISRG:
8.40
NBIX:
$3.10B
ISRG:
$10.58B
NBIX:
$3.05B
ISRG:
$7.02B
NBIX:
$881.20M
ISRG:
$3.76B
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Return for Risk
NBIX vs. ISRG — Risk / Return Rank
NBIX
ISRG
NBIX vs. ISRG - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Neurocrine Biosciences, Inc. (NBIX) and Intuitive Surgical, Inc. (ISRG). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| NBIX | ISRG | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.54 | ||
| Sortino ratioReturn per unit of downside risk | +2.24 | ||
| Omega ratioGain probability vs. loss probability | 1.19 | 0.90 | +0.29 |
| Calmar ratioReturn relative to maximum drawdown | 1.34 | -0.62 | +1.96 |
| Martin ratioReturn relative to average drawdown | 2.94 | -1.24 | +4.18 |
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Drawdowns
NBIX vs. ISRG - Drawdown Comparison
The maximum NBIX drawdown since its inception was -97.21%, which is greater than ISRG's maximum drawdown of -82.26%. Use the drawdown chart below to compare losses from any high point for NBIX and ISRG.
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Drawdown Indicators
| NBIX | ISRG | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -97.21% | -82.26% | -14.95% |
Max Drawdown (1Y)Largest decline over 1 year | -20.90% | -32.14% | +11.24% |
Max Drawdown (3Y)Largest decline over 3 years | -42.89% | -34.10% | -8.79% |
Max Drawdown (5Y)Largest decline over 5 years | -42.89% | -49.90% | +7.01% |
Max Drawdown (10Y)Largest decline over 10 years | -46.39% | -49.90% | +3.51% |
Current DrawdownCurrent decline from peak | -4.54% | -32.66% | +28.12% |
Average DrawdownAverage peak-to-trough decline | -43.84% | -21.28% | -22.56% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 9.49% | 16.00% | -6.51% |
Volatility
NBIX vs. ISRG - Volatility Comparison
Neurocrine Biosciences, Inc. (NBIX) and Intuitive Surgical, Inc. (ISRG) have volatilities of 9.63% and 9.70%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| NBIX | ISRG | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 9.63% | 9.70% | -0.07% |
Volatility (6M)Calculated over the trailing 6-month period | 23.91% | 20.72% | +3.19% |
Volatility (1Y)Calculated over the trailing 1-year period | 31.38% | 30.69% | +0.69% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 32.73% | 33.19% | -0.46% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 39.13% | 32.40% | +6.73% |
Dividends
NBIX vs. ISRG - Dividend Comparison
Neither NBIX nor ISRG has paid dividends to shareholders.
Financials
NBIX vs. ISRG - Financials Comparison
This section allows you to compare key financial metrics between Neurocrine Biosciences, Inc. and Intuitive Surgical, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
NBIX vs. ISRG - Profitability Comparison
NBIX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Neurocrine Biosciences, Inc. reported a gross profit of 800.70M and revenue of 814.50M. Therefore, the gross margin over that period was 98.3%.
ISRG - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported a gross profit of 1.83B and revenue of 2.77B. Therefore, the gross margin over that period was 66.1%.
NBIX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Neurocrine Biosciences, Inc. reported an operating income of 193.40M and revenue of 814.50M, resulting in an operating margin of 23.7%.
ISRG - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported an operating income of 855.30M and revenue of 2.77B, resulting in an operating margin of 30.9%.
NBIX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Neurocrine Biosciences, Inc. reported a net income of 197.90M and revenue of 814.50M, resulting in a net margin of 24.3%.
ISRG - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Intuitive Surgical, Inc. reported a net income of 821.50M and revenue of 2.77B, resulting in a net margin of 29.7%.
Frequently Asked Questions
NBIX and ISRG have a correlation of 0.35, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
ISRG has higher volatility (9.70%) compared to NBIX (9.63%). In terms of maximum drawdown, NBIX dropped -97.21% vs ISRG's -82.26%.
NBIX currently has the higher Sharpe Ratio (0.89 vs -0.65), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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