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ISRG vs. PFE
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Correlation

The correlation between ISRG and PFE is 0.44, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.


Performance

ISRG vs. PFE - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Intuitive Surgical, Inc. (ISRG) and Pfizer Inc. (PFE). The values are adjusted to include any dividend payments, if applicable.

0.00%200.00%400.00%600.00%800.00%1,000.00%December2025FebruaryMarchAprilMay
849.29%
65.13%
ISRG
PFE

Key characteristics

Sharpe Ratio

ISRG:

1.20

PFE:

-0.54

Sortino Ratio

ISRG:

1.89

PFE:

-0.63

Omega Ratio

ISRG:

1.27

PFE:

0.93

Calmar Ratio

ISRG:

1.56

PFE:

-0.22

Martin Ratio

ISRG:

4.99

PFE:

-0.99

Ulcer Index

ISRG:

8.14%

PFE:

13.10%

Daily Std Dev

ISRG:

33.96%

PFE:

23.91%

Max Drawdown

ISRG:

-82.25%

PFE:

-58.96%

Current Drawdown

ISRG:

-12.17%

PFE:

-56.68%

Fundamentals

Market Cap

ISRG:

$189.75B

PFE:

$134.92B

EPS

ISRG:

$6.83

PFE:

$1.41

PE Ratio

ISRG:

77.51

PFE:

16.87

PEG Ratio

ISRG:

3.74

PFE:

0.61

PS Ratio

ISRG:

21.87

PFE:

2.17

PB Ratio

ISRG:

11.09

PFE:

1.56

Total Revenue (TTM)

ISRG:

$8.71B

PFE:

$62.46B

Gross Profit (TTM)

ISRG:

$5.85B

PFE:

$42.09B

EBITDA (TTM)

ISRG:

$2.90B

PFE:

$16.71B

Returns By Period

In the year-to-date period, ISRG achieves a 2.72% return, which is significantly higher than PFE's -12.68% return. Over the past 10 years, ISRG has outperformed PFE with an annualized return of 25.66%, while PFE has yielded a comparatively lower 0.48% annualized return.


ISRG

YTD

2.72%

1M

15.64%

6M

4.00%

1Y

37.95%

5Y*

24.61%

10Y*

25.66%

PFE

YTD

-12.68%

1M

0.71%

6M

-14.01%

1Y

-12.79%

5Y*

-4.44%

10Y*

0.48%

*Annualized

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Risk-Adjusted Performance

ISRG vs. PFE — Risk-Adjusted Performance Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ISRG
The Risk-Adjusted Performance Rank of ISRG is 8686
Overall Rank
The Sharpe Ratio Rank of ISRG is 8787
Sharpe Ratio Rank
The Sortino Ratio Rank of ISRG is 8484
Sortino Ratio Rank
The Omega Ratio Rank of ISRG is 8484
Omega Ratio Rank
The Calmar Ratio Rank of ISRG is 9090
Calmar Ratio Rank
The Martin Ratio Rank of ISRG is 8686
Martin Ratio Rank

PFE
The Risk-Adjusted Performance Rank of PFE is 2626
Overall Rank
The Sharpe Ratio Rank of PFE is 2222
Sharpe Ratio Rank
The Sortino Ratio Rank of PFE is 2121
Sortino Ratio Rank
The Omega Ratio Rank of PFE is 2222
Omega Ratio Rank
The Calmar Ratio Rank of PFE is 3838
Calmar Ratio Rank
The Martin Ratio Rank of PFE is 2929
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

ISRG vs. PFE - Risk-Adjusted Performance Comparison

This table presents a comparison of risk-adjusted performance metrics for Intuitive Surgical, Inc. (ISRG) and Pfizer Inc. (PFE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.


The current ISRG Sharpe Ratio is 1.20, which is higher than the PFE Sharpe Ratio of -0.54. The chart below compares the historical Sharpe Ratios of ISRG and PFE, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.


Rolling 12-month Sharpe Ratio-1.000.001.002.003.004.00December2025FebruaryMarchAprilMay
1.13
-0.54
ISRG
PFE

Dividends

ISRG vs. PFE - Dividend Comparison

ISRG has not paid dividends to shareholders, while PFE's dividend yield for the trailing twelve months is around 7.42%.


TTM20242023202220212020201920182017201620152014
ISRG
Intuitive Surgical, Inc.
0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%
PFE
Pfizer Inc.
7.42%6.33%5.70%3.12%2.64%3.91%3.68%3.12%3.53%3.69%3.47%3.34%

Drawdowns

ISRG vs. PFE - Drawdown Comparison

The maximum ISRG drawdown since its inception was -82.25%, which is greater than PFE's maximum drawdown of -58.96%. Use the drawdown chart below to compare losses from any high point for ISRG and PFE. For additional features, visit the drawdowns tool.


-60.00%-50.00%-40.00%-30.00%-20.00%-10.00%0.00%December2025FebruaryMarchAprilMay
-12.17%
-56.68%
ISRG
PFE

Volatility

ISRG vs. PFE - Volatility Comparison

Intuitive Surgical, Inc. (ISRG) has a higher volatility of 16.51% compared to Pfizer Inc. (PFE) at 10.11%. This indicates that ISRG's price experiences larger fluctuations and is considered to be riskier than PFE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.


5.00%10.00%15.00%20.00%December2025FebruaryMarchAprilMay
16.51%
10.11%
ISRG
PFE

Financials

ISRG vs. PFE - Financials Comparison

This section allows you to compare key financial metrics between Intuitive Surgical, Inc. and Pfizer Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.


Quarterly
Annual

Total Revenue: Total amount of money received from sales and other business activities


0.005.00B10.00B15.00B20.00B25.00B20212022202320242025
2.25B
13.72B
(ISRG) Total Revenue
(PFE) Total Revenue
Values in USD except per share items

ISRG vs. PFE - Profitability Comparison

The chart below illustrates the profitability comparison between Intuitive Surgical, Inc. and Pfizer Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

Gross Margin
Operating Margin
Net Margin
Quarterly
Annual

20.0%30.0%40.0%50.0%60.0%70.0%80.0%20212022202320242025
64.7%
79.3%
(ISRG) Gross Margin
(PFE) Gross Margin
ISRG - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on May 2025, Intuitive Surgical, Inc. reported a gross profit of 1.46B and revenue of 2.25B. Therefore, the gross margin over that period was 64.7%.

PFE - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on May 2025, Pfizer Inc. reported a gross profit of 10.87B and revenue of 13.72B. Therefore, the gross margin over that period was 79.3%.

ISRG - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on May 2025, Intuitive Surgical, Inc. reported an operating income of 578.10M and revenue of 2.25B, resulting in an operating margin of 25.7%.

PFE - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on May 2025, Pfizer Inc. reported an operating income of 2.79B and revenue of 13.72B, resulting in an operating margin of 20.3%.

ISRG - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on May 2025, Intuitive Surgical, Inc. reported a net income of 698.40M and revenue of 2.25B, resulting in a net margin of 31.0%.

PFE - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on May 2025, Pfizer Inc. reported a net income of 2.97B and revenue of 13.72B, resulting in a net margin of 21.6%.