NBIX vs. BMRN

Last updated Apr 2, 2026

Compare and contrast key facts about Neurocrine Biosciences, Inc. (NBIX) and BioMarin Pharmaceutical Inc. (BMRN).

Performance

NBIX vs. BMRN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Neurocrine Biosciences, Inc. (NBIX) and BioMarin Pharmaceutical Inc. (BMRN). The values are adjusted to include any dividend payments, if applicable.

NBIX vs. BMRN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
NBIX Neurocrine Biosciences, Inc.	-6.54%	3.90%	3.60%	10.31%	40.24%	-11.14%	-10.83%	50.53%	-7.96%	100.49%
BMRN BioMarin Pharmaceutical Inc.	-3.69%	-9.58%	-31.83%	-6.83%	17.14%	0.75%	3.71%	-0.70%	-4.51%	7.64%

Fundamentals

Market Cap NBIX : $13.59B BMRN : $11.30B
EPS NBIX : $4.69 BMRN : $1.79
PE Ratio NBIX : 28.25 BMRN : 32.05
PEG Ratio NBIX : 0.56 BMRN : 1.92
PS Ratio NBIX : 4.73 BMRN : 3.47
PB Ratio NBIX : 4.18 BMRN : 1.86
Total Revenue (TTM) NBIX : $2.86B BMRN : $3.22B
Gross Profit (TTM) NBIX : $2.81B BMRN : $2.48B
EBITDA (TTM) NBIX : $719.10M BMRN : $613.03M

Returns By Period

In the year-to-date period, NBIX achieves a -6.54% return, which is significantly lower than BMRN's -3.69% return. Over the past 10 years, NBIX has outperformed BMRN with an annualized return of 12.30%, while BMRN has yielded a comparatively lower -3.84% annualized return.

NBIX

• 1D: 0.62%
• 1M: 0.14%
• YTD: -6.54%
• 6M: -3.24%
• 1Y: 23.89%
• 3Y*: 9.41%
• 5Y*: 6.19%
• 10Y*: 12.30%

BMRN

• 1D: 1.33%
• 1M: -4.18%
• YTD: -3.69%
• 6M: 4.34%
• 1Y: -15.75%
• 3Y*: -16.19%
• 5Y*: -5.96%
• 10Y*: -3.84%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

NBIX vs. BMRN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

NBIX

NBIX Risk / Return Rank: 61
NBIX Sharpe Ratio Rank: 66
NBIX Sortino Ratio Rank: 58
NBIX Omega Ratio Rank: 60
NBIX Calmar Ratio Rank: 61
NBIX Martin Ratio Rank: 62

BMRN

BMRN Risk / Return Rank: 19
BMRN Sharpe Ratio Rank: 21
BMRN Sortino Ratio Rank: 19
BMRN Omega Ratio Rank: 20
BMRN Calmar Ratio Rank: 13
BMRN Martin Ratio Rank: 20

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

NBIX vs. BMRN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Neurocrine Biosciences, Inc. (NBIX) and BioMarin Pharmaceutical Inc. (BMRN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	NBIX	BMRN	Difference
Sharpe ratio Return per unit of total volatility	0.71	-0.45	+1.16
Sortino ratio Return per unit of downside risk	1.13	-0.48	+1.62
Omega ratio Gain probability vs. loss probability	1.16	0.94	+0.22
Calmar ratio Return relative to maximum drawdown	0.95	-0.77	+1.72
Martin ratio Return relative to average drawdown	2.31	-1.12	+3.44
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

NBIX vs. BMRN - Sharpe Ratio Comparison

The current NBIX Sharpe Ratio is 0.71, which is higher than the BMRN Sharpe Ratio of -0.45. The chart below compares the historical Sharpe Ratios of NBIX and BMRN, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	NBIX	BMRN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.71	-0.45	+1.16
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.19	-0.19	+0.38
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.31	-0.11	+0.42
Sharpe Ratio (All Time) Calculated using the full available price history	0.13	0.12	+0.02

Correlation

The correlation between NBIX and BMRN is 0.36, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

NBIX vs. BMRN - Dividend Comparison

Neither NBIX nor BMRN has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

NBIX vs. BMRN - Drawdown Comparison

The maximum NBIX drawdown since its inception was -97.21%, which is greater than BMRN's maximum drawdown of -90.58%. Use the drawdown chart below to compare losses from any high point for NBIX and BMRN.

Drawdown Indicators

	NBIX	BMRN	Difference
Max Drawdown Largest peak-to-trough decline	-97.21%	-90.58%	-6.63%
Max Drawdown (1Y) Largest decline over 1 year	-20.90%	-24.68%	+3.78%
Max Drawdown (5Y) Largest decline over 5 years	-42.89%	-56.12%	+13.23%
Max Drawdown (10Y) Largest decline over 10 years	-46.39%	-60.73%	+14.34%
Current Drawdown Current decline from peak	-14.82%	-61.62%	+46.80%
Average Drawdown Average peak-to-trough decline	-44.05%	-45.39%	+1.34%
Ulcer Index Depth and duration of drawdowns from previous peaks	8.59%	16.93%	-8.34%

Volatility

NBIX vs. BMRN - Volatility Comparison

The current volatility for Neurocrine Biosciences, Inc. (NBIX) is 6.97%, while BioMarin Pharmaceutical Inc. (BMRN) has a volatility of 7.98%. This indicates that NBIX experiences smaller price fluctuations and is considered to be less risky than BMRN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	NBIX	BMRN	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.97%	7.98%	-1.01%
Volatility (6M) Calculated over the trailing 6-month period	23.03%	25.07%	-2.04%
Volatility (1Y) Calculated over the trailing 1-year period	33.89%	35.69%	-1.80%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.22%	32.18%	+0.04%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	39.43%	35.64%	+3.79%

Financials

NBIX vs. BMRN - Profitability Comparison

The chart below illustrates the profitability comparison between Neurocrine Biosciences, Inc. and BioMarin Pharmaceutical Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

NBIX - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Neurocrine Biosciences, Inc. reported a gross profit of 787.90M and revenue of 805.50M. Therefore, the gross margin over that period was 97.8%.

BMRN - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, BioMarin Pharmaceutical Inc. reported a gross profit of 579.47M and revenue of 874.57M. Therefore, the gross margin over that period was 66.3%.

NBIX - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Neurocrine Biosciences, Inc. reported an operating income of 210.90M and revenue of 805.50M, resulting in an operating margin of 26.2%.

BMRN - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, BioMarin Pharmaceutical Inc. reported an operating income of 79.39M and revenue of 874.57M, resulting in an operating margin of 9.1%.

NBIX - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Neurocrine Biosciences, Inc. reported a net income of 153.70M and revenue of 805.50M, resulting in a net margin of 19.1%.

BMRN - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, BioMarin Pharmaceutical Inc. reported a net income of -46.57M and revenue of 874.57M, resulting in a net margin of -5.3%.