ISRG vs. LLY
Compare and contrast key facts about Intuitive Surgical, Inc. (ISRG) and Eli Lilly and Company (LLY).
Performance
ISRG vs. LLY - Performance Comparison
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ISRG vs. LLY - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
ISRG Intuitive Surgical, Inc. | -18.60% | 8.51% | 54.72% | 27.14% | -26.15% | 31.76% | 38.39% | 23.43% | 31.23% | 72.64% |
LLY Eli Lilly and Company | -14.27% | 40.25% | 33.30% | 60.91% | 34.26% | 66.08% | 31.04% | 16.14% | 40.45% | 17.83% |
Fundamentals
ISRG:
$166.14B
LLY:
$825.96B
ISRG:
$7.89
LLY:
$22.96
ISRG:
58.45
LLY:
40.06
ISRG:
3.58
LLY:
0.81
ISRG:
16.59
LLY:
12.68
ISRG:
9.32
LLY:
31.13
ISRG:
$10.06B
LLY:
$65.18B
ISRG:
$6.64B
LLY:
$54.62B
ISRG:
$3.62B
LLY:
$27.94B
Returns By Period
In the year-to-date period, ISRG achieves a -18.60% return, which is significantly lower than LLY's -14.27% return. Over the past 10 years, ISRG has underperformed LLY with an annualized return of 21.20%, while LLY has yielded a comparatively higher 30.92% annualized return.
ISRG
- 1D
- 1.81%
- 1M
- -8.44%
- YTD
- -18.60%
- 6M
- 3.08%
- 1Y
- -6.92%
- 3Y*
- 21.74%
- 5Y*
- 13.09%
- 10Y*
- 21.20%
LLY
- 1D
- 3.74%
- 1M
- -12.57%
- YTD
- -14.27%
- 6M
- 20.93%
- 1Y
- 12.19%
- 3Y*
- 39.90%
- 5Y*
- 39.16%
- 10Y*
- 30.92%
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Return for Risk
ISRG vs. LLY — Risk / Return Rank
ISRG
LLY
ISRG vs. LLY - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Intuitive Surgical, Inc. (ISRG) and Eli Lilly and Company (LLY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| ISRG | LLY | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | -0.21 | 0.29 | -0.49 |
Sortino ratioReturn per unit of downside risk | -0.08 | 0.69 | -0.76 |
Omega ratioGain probability vs. loss probability | 0.99 | 1.10 | -0.10 |
Calmar ratioReturn relative to maximum drawdown | -0.26 | 0.42 | -0.68 |
Martin ratioReturn relative to average drawdown | -0.49 | 1.02 | -1.51 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| ISRG | LLY | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | -0.21 | 0.29 | -0.49 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.40 | 1.23 | -0.83 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.66 | 1.04 | -0.38 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.49 | 0.56 | -0.07 |
Correlation
The correlation between ISRG and LLY is 0.29, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.
Dividends
ISRG vs. LLY - Dividend Comparison
ISRG has not paid dividends to shareholders, while LLY's dividend yield for the trailing twelve months is around 0.68%.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ISRG Intuitive Surgical, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
LLY Eli Lilly and Company | 0.68% | 0.56% | 0.67% | 0.78% | 1.07% | 1.23% | 1.75% | 1.96% | 1.94% | 2.46% | 2.77% | 2.37% |
Drawdowns
ISRG vs. LLY - Drawdown Comparison
The maximum ISRG drawdown since its inception was -82.26%, which is greater than LLY's maximum drawdown of -68.24%. Use the drawdown chart below to compare losses from any high point for ISRG and LLY.
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Drawdown Indicators
| ISRG | LLY | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -82.26% | -68.24% | -14.02% |
Max Drawdown (1Y)Largest decline over 1 year | -24.09% | -30.26% | +6.17% |
Max Drawdown (5Y)Largest decline over 5 years | -49.90% | -34.48% | -15.42% |
Max Drawdown (10Y)Largest decline over 10 years | -49.90% | -34.48% | -15.42% |
Current DrawdownCurrent decline from peak | -24.48% | -17.00% | -7.48% |
Average DrawdownAverage peak-to-trough decline | -21.24% | -19.25% | -1.99% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 12.78% | 12.39% | +0.39% |
Volatility
ISRG vs. LLY - Volatility Comparison
The current volatility for Intuitive Surgical, Inc. (ISRG) is 6.47%, while Eli Lilly and Company (LLY) has a volatility of 9.04%. This indicates that ISRG experiences smaller price fluctuations and is considered to be less risky than LLY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| ISRG | LLY | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 6.47% | 9.04% | -2.57% |
Volatility (6M)Calculated over the trailing 6-month period | 22.11% | 26.21% | -4.10% |
Volatility (1Y)Calculated over the trailing 1-year period | 33.82% | 42.44% | -8.62% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 33.02% | 32.14% | +0.88% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 32.10% | 29.80% | +2.30% |
Financials
ISRG vs. LLY - Financials Comparison
This section allows you to compare key financial metrics between Intuitive Surgical, Inc. and Eli Lilly and Company. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
ISRG vs. LLY - Profitability Comparison
ISRG - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Intuitive Surgical, Inc. reported a gross profit of 1.90B and revenue of 2.87B. Therefore, the gross margin over that period was 66.4%.
LLY - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a gross profit of 16.41B and revenue of 19.29B. Therefore, the gross margin over that period was 85.1%.
ISRG - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Intuitive Surgical, Inc. reported an operating income of 864.30M and revenue of 2.87B, resulting in an operating margin of 30.2%.
LLY - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported an operating income of 8.78B and revenue of 19.29B, resulting in an operating margin of 45.5%.
ISRG - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Intuitive Surgical, Inc. reported a net income of 794.80M and revenue of 2.87B, resulting in a net margin of 27.7%.
LLY - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a net income of 6.64B and revenue of 19.29B, resulting in a net margin of 34.4%.