CRMD vs. ARWR

Last updated Jun 4, 2026

CRMD (CorMedix Inc.) and ARWR (Arrowhead Pharmaceuticals, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 10 years, CRMD returned -4.90%/yr vs 28.05%/yr for ARWR. At a 0.21 correlation, their price movements are largely independent.

Performance

CRMD vs. ARWR - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in CorMedix Inc. (CRMD) and Arrowhead Pharmaceuticals, Inc. (ARWR). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CRMD achieves a -29.23% return, which is significantly lower than ARWR's 9.28% return. Over the past 10 years, CRMD has underperformed ARWR with an annualized return of -4.90%, while ARWR has yielded a comparatively higher 28.05% annualized return.

CRMD

• 1D: 0.73%
• 1M: 4.18%
• YTD: -29.23%
• 6M: -20.25%
• 1Y: -34.73%
• 3Y*: 16.99%
• 5Y*: 2.01%
• 10Y*: -4.90%

ARWR

• 1D: 2.44%
• 1M: -5.03%
• YTD: 9.28%
• 6M: 11.49%
• 1Y: 336.79%
• 3Y*: 26.25%
• 5Y*: -0.96%
• 10Y*: 28.05%

*Multi-year figures are annualized to reflect compound growth (CAGR)

CRMD vs. ARWR - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
CRMD CorMedix Inc.	-29.23%	43.58%	115.43%	-10.90%	-7.25%	-38.76%	2.06%	12.87%	158.00%	-67.32%
ARWR Arrowhead Pharmaceuticals, Inc.	9.28%	253.14%	-38.56%	-24.56%	-38.82%	-13.59%	20.97%	410.71%	237.50%	137.42%

Correlation

The correlation between CRMD and ARWR is 0.28, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.28
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.35
Correlation (10Y) Calculated over the trailing 10-year period	0.25
Correlation (All Time) Calculated using the full available price history since May 14, 2010	0.21

The correlation between CRMD and ARWR shifts across timeframes, from 0.21 (all time) to 0.35 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap CRMD : $765.27M ARWR : $10.33B
EPS CRMD : $2.10 ARWR : -$2.16
PS Ratio CRMD : 1.77 ARWR : 16.27
PB Ratio CRMD : 1.75 ARWR : 17.25
Total Revenue (TTM) CRMD : $400.05M ARWR : $622.01M
Gross Profit (TTM) CRMD : $343.39M ARWR : $529.27M
EBITDA (TTM) CRMD : $207.97M ARWR : -$168.38M

Return for Risk

CRMD vs. ARWR — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CRMD

CRMD Risk / Return Rank: 22
CRMD Sharpe Ratio Rank: 19
CRMD Sortino Ratio Rank: 23
CRMD Omega Ratio Rank: 22
CRMD Calmar Ratio Rank: 21
CRMD Martin Ratio Rank: 25

ARWR

ARWR Risk / Return Rank: 98
ARWR Sharpe Ratio Rank: 99
ARWR Sortino Ratio Rank: 97
ARWR Omega Ratio Rank: 95
ARWR Calmar Ratio Rank: 98
ARWR Martin Ratio Rank: 98

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CRMD vs. ARWR - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for CorMedix Inc. (CRMD) and Arrowhead Pharmaceuticals, Inc. (ARWR). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CRMD	ARWR	Difference
Sharpe ratio Return per unit of total volatility	-0.51	5.22	-5.72
Sortino ratio Return per unit of downside risk	-0.34	4.69	-5.04
Omega ratio Gain probability vs. loss probability	0.95	1.59	-0.64
Calmar ratio Return relative to maximum drawdown	-0.56	13.77	-14.33
Martin ratio Return relative to average drawdown	-0.83	37.74	-38.57
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CRMD vs. ARWR - Sharpe Ratio Comparison

The current CRMD Sharpe Ratio is -0.51, which is lower than the ARWR Sharpe Ratio of 5.22. The chart below compares the historical Sharpe Ratios of CRMD and ARWR, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CRMD	ARWR	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.51	5.22	-5.72
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.03	-0.01	+0.04
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.05	0.38	-0.43
Sharpe Ratio (All Time) Calculated using the full available price history	-0.04	-0.01	-0.03

Drawdowns

CRMD vs. ARWR - Drawdown Comparison

The maximum CRMD drawdown since its inception was -98.28%, roughly equal to the maximum ARWR drawdown of -99.24%. Use the drawdown chart below to compare losses from any high point for CRMD and ARWR.

Drawdown Indicators

	CRMD	ARWR	Difference
Max Drawdown Largest peak-to-trough decline	-98.28%	-99.24%	+0.96%
Max Drawdown (1Y) Largest decline over 1 year	-62.26%	-24.64%	-37.62%
Max Drawdown (3Y) Largest decline over 3 years	-62.26%	-74.70%	+12.44%
Max Drawdown (5Y) Largest decline over 5 years	-66.91%	-88.94%	+22.03%
Max Drawdown (10Y) Largest decline over 10 years	-94.77%	-88.96%	-5.81%
Current Drawdown Current decline from peak	-83.32%	-55.35%	-27.97%
Average Drawdown Average peak-to-trough decline	-76.98%	-81.24%	+4.26%
Ulcer Index Depth and duration of drawdowns from previous peaks	41.81%	8.97%	+32.84%

Volatility

CRMD vs. ARWR - Volatility Comparison

The current volatility for CorMedix Inc. (CRMD) is 12.63%, while Arrowhead Pharmaceuticals, Inc. (ARWR) has a volatility of 17.17%. This indicates that CRMD experiences smaller price fluctuations and is considered to be less risky than ARWR based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CRMD	ARWR	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.63%	17.17%	-4.54%
Volatility (6M) Calculated over the trailing 6-month period	52.14%	39.41%	+12.73%
Volatility (1Y) Calculated over the trailing 1-year period	68.84%	65.03%	+3.81%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	77.14%	65.03%	+12.11%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	91.78%	74.14%	+17.64%

Dividends

CRMD vs. ARWR - Dividend Comparison

Neither CRMD nor ARWR has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CRMD and ARWR in my portfolio?

CRMD and ARWR have a correlation of 0.28, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CRMD or ARWR?

ARWR has higher volatility (17.17%) compared to CRMD (12.63%). In terms of maximum drawdown, CRMD dropped -98.28% vs ARWR's -99.24%.

Which has better risk-adjusted returns?

ARWR currently has the higher Sharpe Ratio (5.22 vs -0.51), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.