Invesco S&P SmallCap Health Care ETF (PSCH) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with PSCH. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to PSCH
PSCH charges 0.29% annually. There are 5 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.99B | Oct 2013 | PSCH vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.47B | Dec 1998 | PSCH vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | PSCH vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | PSCH vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | PSCH vs GSKH |
Best Risk-Adjusted Alternatives to PSCH
PSCH has a PortfoliosLab risk / return rank of 34. There are 34 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 95.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 95 | 40.93M | Dec 2014 | PSCH vs BBC | |
| ALPS Medical Breakthroughs ETF | 92 | 160.12M | Dec 2014 | PSCH vs SBIO | |
| SPDR S&P Biotech ETF | 90 | 8.62B | Feb 2006 | PSCH vs XBI | |
| iShares Neuroscience and Healthcare ETF | 89 | 5.39M | Aug 2022 | PSCH vs IBRN | |
| First Trust Nasdaq Pharmaceuticals ETF | 87 | 33.60M | Sep 2016 | PSCH vs FTXH |
Top Performing PSCH Alternatives (YTD)
PSCH is at 11.73% YTD. There are 14 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 27.05%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| Roundhill UNH WeeklyPay ETF | 27.05% | 4.79M | Dec 2025 | PSCH vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 25.75% | 40.93M | Dec 2014 | PSCH vs BBC | |
| AdvisorShares Psychedelics ETF | 25.04% | 33.07M | Sep 2021 | PSCH vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 24.30% | 1.31B | Oct 2014 | PSCH vs ARKG | |
| SPDR S&P Biotech ETF | 20.70% | 8.62B | Feb 2006 | PSCH vs XBI |
Lowest Volatility Alternatives to PSCH
PSCH has 20.45% 1-year volatility. There are 33 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | PSCH vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PSCH vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.65% | 10.10M | Jun 2007 | PSCH vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.06% | 14.95M | Jul 2025 | PSCH vs XLVI | |
| Global X Aging Population ETF | 13.70% | 80.19M | May 2016 | PSCH vs AGNG |
Lowest Drawdown Alternatives to PSCH
PSCH has a 1-year max drawdown of -15.36%. There are 37 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PSCH vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.00% | 10.10M | Jun 2007 | PSCH vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 33.60M | Sep 2016 | PSCH vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 68.94M | Jun 2021 | PSCH vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 956.44M | May 2006 | PSCH vs IHE |
Other ETFs from Invesco
The 10 most viewed Invesco ETFs shown here include QQQ, SPMO, QQQM and span 12 categories. AUM among these funds goes as high as $493B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Invesco QQQ ETF | Nasdaq-100 | 59 | 16.45% | 493.17B | Mar 1999 | PSCH vs QQQ | |
| Invesco S&P 500 Momentum ETF | Momentum, S&P 500 | 68 | 29.91% | 21.99B | Oct 2015 | PSCH vs SPMO | |
| Invesco NASDAQ 100 ETF | Nasdaq-100 | 60 | 16.48% | 101.29B | Oct 2020 | PSCH vs QQQM | |
| Invesco S&P 500 Equal Weight ETF | S&P 500, Equal Weight | 49 | 9.94% | 92.57B | Apr 2003 | PSCH vs RSP | |
| Invesco PHLX Semiconductor ETF | Semiconductors, Technology Equities | 94 | 90.62% | 3.22B | Jun 2021 | PSCH vs SOXQ | |
| Invesco S&P 500 Top 50 ETF | S&P 500 | 39 | 1.60% | 10.60B | May 2005 | PSCH vs XLG | |
| Invesco S&P 500 Quality ETF | S&P 500, Large Cap Blend Equities | 61 | 16.54% | 21.05B | Dec 2005 | PSCH vs SPHQ | |
| Invesco S&P 500® High Dividend Low Volatility ETF | Dividend, S&P 500, Large Cap Value Equities | 30 | 8.20% | 3.27B | Oct 2012 | PSCH vs SPHD | |
| Invesco S&P MidCap Momentum ETF | Momentum, Mid Cap Growth Equities | 66 | 22.90% | 8.18B | Mar 2005 | PSCH vs XMMO | |
| Invesco Aerospace & Defense ETF | Aerospace & Defense, Industrials Equities | 38 | 9.76% | 8.26B | Oct 2005 | PSCH vs PPA |
Often Compared With PSCH
Investors most often compare PSCH with XHE, IBB, SOXX. These 20 comparison targets span 6 categories, based on PortfoliosLab usage data.
Compare PSCH with Any Fund or Stock
Compare PSCH with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair PSCH with funds that move differently
Invesco S&P SmallCap Health Care ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to PSCH.
Explore PSCH Diversifiers