Portfolio Building Block World Pharma and Biotech Index ETF (PBPH) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with PBPH. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to PBPH
PBPH charges 0.13% annually. There are 3 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | PBPH vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | PBPH vs XLV | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | PBPH vs VHT | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | PBPH vs GSKH | |
| Invesco Nasdaq Biotechnology ETF | 0.19% | 74.65M | Jun 2021 | PBPH vs IBBQ |
Best Risk-Adjusted Alternatives to PBPH
Among 56 ETFs in the Health & Biotech Equities category with risk / return rank data, the top risk-adjusted alternatives shown here go as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | PBPH vs BBC | |
| ALPS Medical Breakthroughs ETF | 94 | 213.08M | Dec 2014 | PBPH vs SBIO | |
| First Trust Nasdaq Pharmaceuticals ETF | 94 | 36.36M | Sep 2016 | PBPH vs FTXH | |
| iShares U.S. Pharmaceuticals ETF | 93 | 1.34B | May 2006 | PBPH vs IHE | |
| SPDR S&P Biotech ETF | 93 | 11.10B | Feb 2006 | PBPH vs XBI |
Top Performing PBPH Alternatives (YTD)
PBPH is at 7.57% YTD. There are 34 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 41.35%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 41.35% | 44.37M | Sep 2021 | PBPH vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 38.38% | 1.31B | Oct 2014 | PBPH vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 31.46% | 6.01M | Dec 2025 | PBPH vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 29.44% | 57.56M | Dec 2014 | PBPH vs BBC | |
| SPDR S&P Health Care Services ETF | 26.76% | 204.10M | Sep 2011 | PBPH vs XHS |
Lowest Volatility Alternatives to PBPH
PBPH has 17.85% 1-year volatility. There are 22 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | PBPH vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBPH vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.62% | 10.11M | Jun 2007 | PBPH vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.06% | 16.78M | Jul 2025 | PBPH vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.54% | 982.35K | Apr 2026 | PBPH vs MHIP |
Lowest Drawdown Alternatives to PBPH
Among 57 ETFs in the Health & Biotech Equities category with 1-year drawdown data, the lowest-drawdown alternatives shown here go as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBPH vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | PBPH vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | PBPH vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | PBPH vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | PBPH vs IHE |
Other ETFs from Portfolio Building Block
The 1 most viewed Portfolio Building Block ETFs shown here include PBEU and span 2 categories. AUM among these funds goes as high as $443M.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Portfolio Building Block European Banks Index ETF | Financials Equities, Europe Equities | — | 17.19% | 443.13M | Nov 2025 | PBPH vs PBEU |
Often Compared With PBPH
Investors most often compare PBPH with VT, IDNA, DVXV. These 20 comparison targets span 3 categories, based on PortfoliosLab usage data.
Compare PBPH with Any Fund or Stock
Compare PBPH with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair PBPH with funds that move differently
Portfolio Building Block World Pharma and Biotech Index ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to PBPH.
Explore PBPH Diversifiers