Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with PBE. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to PBE
PBE charges 0.59% annually. There are 36 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | PBE vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | PBE vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | PBE vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | PBE vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | PBE vs GSKH |
Best Risk-Adjusted Alternatives to PBE
PBE has a PortfoliosLab risk / return rank of 78. There are 18 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | PBE vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | PBE vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | PBE vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | PBE vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | PBE vs IBRN |
Top Performing PBE Alternatives (YTD)
PBE is at 11.42% YTD. There are 26 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | PBE vs ARKG | |
| AdvisorShares Psychedelics ETF | 38.09% | 44.37M | Sep 2021 | PBE vs PSIL | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | PBE vs BBC | |
| Roundhill UNH WeeklyPay ETF | 32.77% | 6.01M | Dec 2025 | PBE vs UNHW | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | PBE vs SBIO |
Lowest Volatility Alternatives to PBE
PBE has 19.05% 1-year volatility. There are 30 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBE vs GERM | |
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | PBE vs CNCR | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | PBE vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.89% | 16.78M | Jul 2025 | PBE vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.77% | 982.35K | Apr 2026 | PBE vs MHIP |
Lowest Drawdown Alternatives to PBE
PBE has a 1-year max drawdown of -11.73%. There are 26 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBE vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | PBE vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | PBE vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 74.65M | Jun 2021 | PBE vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | PBE vs IHE |
Other ETFs from Invesco
The 10 most viewed Invesco ETFs shown here include QQQ, SPMO, QQQM and span 12 categories. AUM among these funds goes as high as $481B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Invesco QQQ ETF | Nasdaq-100 | 58 | 16.13% | 481.14B | Mar 1999 | PBE vs QQQ | |
| Invesco S&P 500 Momentum ETF | Momentum, S&P 500 | 62 | 26.03% | 22.01B | Oct 2015 | PBE vs SPMO | |
| Invesco NASDAQ 100 ETF | Nasdaq-100 | 59 | 16.16% | 100.59B | Oct 2020 | PBE vs QQQM | |
| Invesco S&P 500 Equal Weight ETF | S&P 500, Equal Weight | 58 | 12.75% | 96.24B | Apr 2003 | PBE vs RSP | |
| Invesco PHLX Semiconductor ETF | Semiconductors, Technology Equities | 92 | 74.43% | 2.58B | Jun 2021 | PBE vs SOXQ | |
| Invesco S&P 500 Top 50 ETF | S&P 500 | 40 | 3.75% | 10.85B | May 2005 | PBE vs XLG | |
| Invesco S&P 500 Quality ETF | S&P 500, Large Cap Blend Equities | 65 | 16.39% | 20.11B | Dec 2005 | PBE vs SPHQ | |
| Invesco S&P 500® High Dividend Low Volatility ETF | Dividend, S&P 500, Large Cap Value Equities | 37 | 11.46% | 3.29B | Oct 2012 | PBE vs SPHD | |
| Invesco S&P MidCap Momentum ETF | Momentum, Mid Cap Growth Equities | 50 | 14.98% | 7.45B | Mar 2005 | PBE vs XMMO | |
| Invesco Aerospace & Defense ETF | Aerospace & Defense, Industrials Equities | 35 | 9.54% | 8.22B | Oct 2005 | PBE vs PPA |
Often Compared With PBE
Investors most often compare PBE with BBH, IBB, IDNA. These 20 comparison targets span 6 categories, based on PortfoliosLab usage data.
Compare PBE with Any Fund or Stock
Compare PBE with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair PBE with funds that move differently
Invesco Dynamic Biotechnology & Genome ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to PBE.
Explore PBE Diversifiers