Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with PBE. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to PBE
PBE charges 0.59% annually. There are 34 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.85B | Oct 2013 | PBE vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.66B | Dec 1998 | PBE vs XLV | |
| Vanguard Health Care ETF | 0.09% | 18.50B | Jan 2004 | PBE vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | PBE vs PBPH | |
| Invesco S&P SmallCap Health Care ETF | 0.29% | 131.36M | Apr 2010 | PBE vs PSCH |
Best Risk-Adjusted Alternatives to PBE
PBE has a PortfoliosLab risk / return rank of 47. There are 19 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 89.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 89 | 43.63M | Dec 2014 | PBE vs BBC | |
| SPDR S&P Biotech ETF | 74 | 8.28B | Feb 2006 | PBE vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 74 | 912.87M | May 2006 | PBE vs IHE | |
| ALPS Medical Breakthroughs ETF | 72 | 161.79M | Dec 2014 | PBE vs SBIO | |
| First Trust Nasdaq Pharmaceuticals ETF | 71 | 35.04M | Sep 2016 | PBE vs FTXH |
Top Performing PBE Alternatives (YTD)
PBE is at 0.58% YTD. There are 27 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 20.15%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 20.15% | 35.56M | Sep 2021 | PBE vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 17.09% | 1.24B | Oct 2014 | PBE vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 15.08% | 4.48M | Dec 2025 | PBE vs UNHW | |
| iShares Genomics Immunology and Healthcare ETF Gen... | 10.31% | 163.14M | Jun 2019 | PBE vs IDNA | |
| Virtus LifeSci Biotech Clinical Trials ETF | 8.64% | 43.63M | Dec 2014 | PBE vs BBC |
Lowest Volatility Alternatives to PBE
PBE has 18.71% 1-year volatility. There are 29 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Principal Healthcare Innovators Index ETF | 0.00% | 16.16M | Aug 2016 | PBE vs BTEC | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBE vs GERM | |
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | PBE vs CNCR | |
| Horizon Kinetics SPAC Active ETF | 8.80% | 10.01M | Jun 2007 | PBE vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.94% | 14.25M | Jul 2025 | PBE vs XLVI |
Lowest Drawdown Alternatives to PBE
PBE has a 1-year max drawdown of -11.73%. There are 25 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBE vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.30% | 10.01M | Jun 2007 | PBE vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 35.04M | Sep 2016 | PBE vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 67.37M | Jun 2021 | PBE vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 912.87M | May 2006 | PBE vs IHE |
Other ETFs from Invesco
The 10 most viewed Invesco ETFs shown here include QQQ, SPMO, QQQM and span 11 categories. AUM among these funds goes as high as $494B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Invesco QQQ ETF | Nasdaq-100 | 73 | 21.30% | 493.99B | Mar 1999 | PBE vs QQQ | |
| Invesco S&P 500 Momentum ETF | Momentum, S&P 500 | 75 | 30.35% | 19.93B | Oct 2015 | PBE vs SPMO | |
| Invesco NASDAQ 100 ETF | Nasdaq-100 | 74 | 21.39% | 96.91B | Oct 2020 | PBE vs QQQM | |
| Invesco S&P 500 Equal Weight ETF | S&P 500 | 49 | 9.70% | 89.51B | Apr 2003 | PBE vs RSP | |
| Invesco S&P 500 Top 50 ETF | S&P 500 | 56 | 7.57% | 11.15B | May 2005 | PBE vs XLG | |
| Invesco PHLX Semiconductor ETF | Semiconductors, Technology Equities | 96 | 96.72% | 2.41B | Jun 2021 | PBE vs SOXQ | |
| Invesco S&P 500 Quality ETF | S&P 500, Large Cap Blend Equities | 54 | 15.48% | 18.88B | Dec 2005 | PBE vs SPHQ | |
| Invesco S&P 500® High Dividend Low Volatility ETF | Dividend, S&P 500, Large Cap Value Equities | 21 | 4.38% | 3.23B | Oct 2012 | PBE vs SPHD | |
| Invesco Aerospace & Defense ETF | Aerospace & Defense, Industrials Equities | 37 | 8.54% | 8.37B | Oct 2005 | PBE vs PPA | |
| Invesco S&P MidCap Momentum ETF | Momentum, Mid Cap Growth Equities | 67 | 23.73% | 7.49B | Mar 2005 | PBE vs XMMO |
Often Compared With PBE
Investors most often compare PBE with BBH, IBB, PJP. These 20 comparison targets span 7 categories, based on PortfoliosLab usage data.
Compare PBE with Any Fund or Stock
Compare PBE with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair PBE with funds that move differently
Invesco Dynamic Biotechnology & Genome ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to PBE.
Explore PBE Diversifiers