Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with PBE. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to PBE
PBE charges 0.59% annually. There are 37 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 42.10B | Dec 1998 | PBE vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | PBE vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 20.40B | Jan 2004 | PBE vs VHT | |
| VanEck Healthcare TruSector ETF | 0.10% | 850.50K | Apr 2026 | PBE vs TRUH | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 933.15M | Nov 2025 | PBE vs PBPH |
Best Risk-Adjusted Alternatives to PBE
PBE has a PortfoliosLab risk / return rank of 85. There are 18 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| iShares U.S. Pharmaceuticals ETF | 96 | 1.65B | May 2006 | PBE vs IHE | |
| First Trust Nasdaq Pharmaceuticals ETF | 96 | 911.09M | Sep 2016 | PBE vs FTXH | |
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 47.80M | Dec 2014 | PBE vs BBC | |
| Invesco Dynamic Pharmaceuticals ETF | 95 | 472.10M | Jun 2005 | PBE vs PJP | |
| ALPS Medical Breakthroughs ETF | 95 | 201.57M | Dec 2014 | PBE vs SBIO |
Top Performing PBE Alternatives (YTD)
PBE is at 10.26% YTD. There are 28 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 36.87%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 36.87% | 48.53M | Sep 2021 | PBE vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 33.10% | 1.73B | Oct 2014 | PBE vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 28.78% | 7.27M | Dec 2025 | PBE vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 26.39% | 47.80M | Dec 2014 | PBE vs BBC | |
| F/m Emerald Life Sciences Innovation ETF | 24.40% | 74.65M | Oct 2024 | PBE vs LFSC |
Lowest Volatility Alternatives to PBE
PBE has 18.83% 1-year volatility. There are 28 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | PBE vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBE vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.65% | 10.09M | Jun 2007 | PBE vs SPAQ | |
| Milliman Healthcare Inflation Plus ETF | 10.97% | 982.35K | Apr 2026 | PBE vs MHIP | |
| State Street Health Care Select Sector SPDR Premiu... | 11.07% | 21.55M | Jul 2025 | PBE vs XLVI |
Lowest Drawdown Alternatives to PBE
PBE has a 1-year max drawdown of -11.73%. There are 27 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | PBE vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.20% | 10.09M | Jun 2007 | PBE vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 911.09M | Sep 2016 | PBE vs FTXH | |
| State Street Health Care Select Sector SPDR Premiu... | -8.14% | 21.55M | Jul 2025 | PBE vs XLVI | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 75.06M | Jun 2021 | PBE vs IBBQ |
Other ETFs from Invesco
The 10 most viewed Invesco ETFs shown here include QQQ, SPMO, QQQM and span 12 categories. AUM among these funds goes as high as $453B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Invesco QQQ ETF | Nasdaq-100 | 49 | 12.26% | 452.80B | Mar 1999 | PBE vs QQQ | |
| Invesco S&P 500 Momentum ETF | Momentum, S&P 500 | 46 | 21.07% | 21.05B | Oct 2015 | PBE vs SPMO | |
| Invesco NASDAQ 100 ETF | Nasdaq-100 | 49 | 12.29% | 97.11B | Oct 2020 | PBE vs QQQM | |
| Invesco S&P 500 Equal Weight ETF | S&P 500, Equal Weight | 73 | 13.16% | 96.96B | Apr 2003 | PBE vs RSP | |
| Invesco PHLX Semiconductor ETF | Semiconductors, Technology Equities | 88 | 59.97% | 2.58B | Jun 2021 | PBE vs SOXQ | |
| Invesco S&P 500 Quality ETF | Quality Factor, S&P 500, Large Cap Blend Equities | 62 | 13.51% | 19.45B | Dec 2005 | PBE vs SPHQ | |
| Invesco S&P 500 Top 50 ETF | S&P 500 | 35 | 2.89% | 10.56B | May 2005 | PBE vs XLG | |
| Invesco S&P 500® High Dividend Low Volatility ETF | Dividend, S&P 500, Low Volatility | 53 | 12.28% | 4.04B | Oct 2012 | PBE vs SPHD | |
| Invesco S&P MidCap Momentum ETF | Momentum, Mid Cap Growth Equities | 39 | 11.79% | 7.18B | Mar 2005 | PBE vs XMMO | |
| Invesco S&P International Developed Momentum ETF | Momentum, Foreign Large Cap Equities | 55 | 10.66% | 4.08B | Feb 2012 | PBE vs IDMO |
Often Compared With PBE
Investors most often compare PBE with XBI, BBH, IBB. These 20 comparison targets span 9 categories, based on PortfoliosLab usage data.
Compare PBE with Any Fund or Stock
Compare PBE with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair PBE with funds that move differently
Invesco Dynamic Biotechnology & Genome ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to PBE.
Explore PBE Diversifiers