iShares U.S. Pharmaceuticals ETF (IHE) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with IHE. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to IHE
IHE charges 0.42% annually. There are 13 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.66B | Dec 1998 | IHE vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.85B | Oct 2013 | IHE vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 18.50B | Jan 2004 | IHE vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | IHE vs PBPH | |
| Invesco S&P SmallCap Health Care ETF | 0.29% | 131.36M | Apr 2010 | IHE vs PSCH |
Best Risk-Adjusted Alternatives to IHE
IHE has a PortfoliosLab risk / return rank of 74. There are 2 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 89.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 89 | 43.63M | Dec 2014 | IHE vs BBC | |
| SPDR S&P Biotech ETF | 74 | 8.28B | Feb 2006 | IHE vs XBI | |
| ALPS Medical Breakthroughs ETF | 72 | 161.79M | Dec 2014 | IHE vs SBIO | |
| First Trust Nasdaq Pharmaceuticals ETF | 71 | 35.04M | Sep 2016 | IHE vs FTXH | |
| iShares Neuroscience and Healthcare ETF | 69 | 5.38M | Aug 2022 | IHE vs IBRN |
Top Performing IHE Alternatives (YTD)
IHE is at 6.47% YTD. There are 8 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 20.15%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 20.15% | 35.56M | Sep 2021 | IHE vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 17.09% | 1.24B | Oct 2014 | IHE vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 15.08% | 4.48M | Dec 2025 | IHE vs UNHW | |
| iShares Genomics Immunology and Healthcare ETF Gen... | 10.31% | 163.14M | Jun 2019 | IHE vs IDNA | |
| Virtus LifeSci Biotech Clinical Trials ETF | 8.64% | 43.63M | Dec 2014 | IHE vs BBC |
Lowest Volatility Alternatives to IHE
IHE has 17.07% 1-year volatility. There are 22 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Principal Healthcare Innovators Index ETF | 0.00% | 16.16M | Aug 2016 | IHE vs BTEC | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IHE vs GERM | |
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | IHE vs CNCR | |
| Horizon Kinetics SPAC Active ETF | 8.80% | 10.01M | Jun 2007 | IHE vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.94% | 14.25M | Jul 2025 | IHE vs XLVI |
Lowest Drawdown Alternatives to IHE
IHE has a 1-year max drawdown of -8.47%. There are 4 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IHE vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.30% | 10.01M | Jun 2007 | IHE vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 35.04M | Sep 2016 | IHE vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 67.37M | Jun 2021 | IHE vs IBBQ | |
| Tema Oncology ETF | -8.67% | 142.24M | Aug 2023 | IHE vs CANC |
Other ETFs from iShares
The 10 most viewed iShares ETFs shown here include SGOV, IBIT, IVV and span 14 categories. AUM among these funds goes as high as $855B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| iShares 0-3 Month Treasury Bond ETF | Ultrashort Bond | 100 | 1.51% | 91.90B | May 2020 | IHE vs SGOV | |
| iShares Bitcoin Trust ETF | Cryptocurrency | 2 | -25.48% | 58.12B | Jan 2024 | IHE vs IBIT | |
| iShares Core S&P 500 ETF | S&P 500 | 70 | 10.85% | 854.92B | May 2000 | IHE vs IVV | |
| iShares 20+ Year Treasury Bond ETF | Government Bonds, Long-Term Bond | 16 | -0.27% | 42.90B | Jul 2002 | IHE vs TLT | |
| iShares Semiconductor ETF | Semiconductors, Technology Equities | 97 | 104.57% | 38.37B | Jul 2001 | IHE vs SOXX | |
| iShares Core Dividend Growth ETF | Large Cap Growth Equities, Dividend | 71 | 8.76% | 40.46B | Jun 2014 | IHE vs DGRO | |
| iShares Silver Trust | Silver, Precious Metals | 47 | 2.78% | 36.82B | Apr 2006 | IHE vs SLV | |
| iShares Gold Trust | Gold, Precious Metals | 32 | 2.98% | 69.92B | Jan 2005 | IHE vs IAU | |
| iShares Russell 2000 ETF | Small Cap Blend Equities | 62 | 17.07% | 80.93B | May 2000 | IHE vs IWM | |
| iShares MSCI ACWI ETF | Global Equities | 66 | 12.13% | 32.93B | Mar 2008 | IHE vs ACWI |
Often Compared With IHE
Investors most often compare IHE with PPH, XPH, VYM. These 20 comparison targets span 8 categories, based on PortfoliosLab usage data.
Compare IHE with Any Fund or Stock
Compare IHE with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair IHE with funds that move differently
iShares U.S. Pharmaceuticals ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to IHE.
Explore IHE Diversifiers