Invesco Nasdaq Biotechnology ETF (IBBQ) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with IBBQ. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to IBBQ
IBBQ charges 0.00% annually. No ETFs in the Health & Biotech Equities category have lower expense ratios; the lowest-cost alternatives shown here go as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.85B | Oct 2013 | IBBQ vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.66B | Dec 1998 | IBBQ vs XLV | |
| Vanguard Health Care ETF | 0.10% | 18.50B | Jan 2004 | IBBQ vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | IBBQ vs PBPH | |
| Invesco S&P SmallCap Health Care ETF | 0.29% | 131.36M | Apr 2010 | IBBQ vs PSCH |
Best Risk-Adjusted Alternatives to IBBQ
IBBQ has a PortfoliosLab risk / return rank of 67. There are 8 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 90.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 90 | 43.63M | Dec 2014 | IBBQ vs BBC | |
| SPDR S&P Biotech ETF | 75 | 8.28B | Feb 2006 | IBBQ vs XBI | |
| ALPS Medical Breakthroughs ETF | 74 | 161.79M | Dec 2014 | IBBQ vs SBIO | |
| iShares U.S. Pharmaceuticals ETF | 72 | 912.87M | May 2006 | IBBQ vs IHE | |
| Tema Oncology ETF | 70 | 142.24M | Aug 2023 | IBBQ vs CANC |
Top Performing IBBQ Alternatives (YTD)
IBBQ is at 0.14% YTD. There are 23 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 23.33%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 23.33% | 35.56M | Sep 2021 | IBBQ vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 17.36% | 1.24B | Oct 2014 | IBBQ vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 15.01% | 4.48M | Dec 2025 | IBBQ vs UNHW | |
| iShares Genomics Immunology and Healthcare ETF Gen... | 9.51% | 163.14M | Jun 2019 | IBBQ vs IDNA | |
| Virtus LifeSci Biotech Clinical Trials ETF | 8.17% | 43.63M | Dec 2014 | IBBQ vs BBC |
Lowest Volatility Alternatives to IBBQ
IBBQ has 19.63% 1-year volatility. There are 32 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Principal Healthcare Innovators Index ETF | 0.00% | 16.16M | Aug 2016 | IBBQ vs BTEC | |
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | IBBQ vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IBBQ vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.80% | 10.01M | Jun 2007 | IBBQ vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.94% | 14.25M | Jul 2025 | IBBQ vs XLVI |
Lowest Drawdown Alternatives to IBBQ
IBBQ has a 1-year max drawdown of -8.34%. There are 3 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IBBQ vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.30% | 10.01M | Jun 2007 | IBBQ vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 35.04M | Sep 2016 | IBBQ vs FTXH | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 912.87M | May 2006 | IBBQ vs IHE | |
| Tema Oncology ETF | -8.67% | 142.24M | Aug 2023 | IBBQ vs CANC |
Other ETFs from Invesco
The 10 most viewed Invesco ETFs shown here include QQQ, SPMO, QQQM and span 10 categories. AUM among these funds goes as high as $494B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Invesco QQQ ETF | Nasdaq-100 | 77 | 21.62% | 493.99B | Mar 1999 | IBBQ vs QQQ | |
| Invesco S&P 500 Momentum ETF | Momentum, S&P 500 | 77 | 29.70% | 19.93B | Oct 2015 | IBBQ vs SPMO | |
| Invesco NASDAQ 100 ETF | Nasdaq-100 | 77 | 21.64% | 96.91B | Oct 2020 | IBBQ vs QQQM | |
| Invesco S&P 500 Equal Weight ETF | S&P 500 | 54 | 10.12% | 89.51B | Apr 2003 | IBBQ vs RSP | |
| Invesco S&P 500 Top 50 ETF | S&P 500 | 62 | 8.82% | 11.15B | May 2005 | IBBQ vs XLG | |
| Invesco PHLX Semiconductor ETF | Semiconductors, Technology Equities | 97 | 93.97% | 2.41B | Jun 2021 | IBBQ vs SOXQ | |
| Invesco S&P 500 Quality ETF | S&P 500, Large Cap Value Equities | 56 | 15.16% | 18.88B | Dec 2005 | IBBQ vs SPHQ | |
| Invesco S&P 500® High Dividend Low Volatility ETF | S&P 500, Dividend | 24 | 5.32% | 3.23B | Oct 2012 | IBBQ vs SPHD | |
| Invesco Aerospace & Defense ETF | Industrials Equities, Aerospace & Defense | 43 | 10.46% | 8.37B | Oct 2005 | IBBQ vs PPA | |
| Invesco S&P MidCap Momentum ETF | Momentum, Mid Cap Growth Equities | 69 | 22.96% | 7.49B | Mar 2005 | IBBQ vs XMMO |
Often Compared With IBBQ
Investors most often compare IBBQ with IBB, BBH, GNOM. These 20 comparison targets span 5 categories, based on PortfoliosLab usage data.
Compare IBBQ with Any Fund or Stock
Compare IBBQ with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair IBBQ with funds that move differently
Invesco Nasdaq Biotechnology ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to IBBQ.
Explore IBBQ Diversifiers