Invesco Nasdaq Biotechnology ETF (IBBQ) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with IBBQ. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to IBBQ
IBBQ charges 0.19% annually. There are 4 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 41.65B | Dec 1998 | IBBQ vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 3.22B | Oct 2013 | IBBQ vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | IBBQ vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 951.16M | Nov 2025 | IBBQ vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | IBBQ vs GSKH |
Best Risk-Adjusted Alternatives to IBBQ
IBBQ has a PortfoliosLab risk / return rank of 91. There are 11 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 96.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 96 | 57.56M | Dec 2014 | IBBQ vs BBC | |
| ALPS Medical Breakthroughs ETF | 95 | 213.08M | Dec 2014 | IBBQ vs SBIO | |
| SPDR S&P Biotech ETF | 94 | 11.10B | Feb 2006 | IBBQ vs XBI | |
| iShares U.S. Pharmaceuticals ETF | 94 | 1.34B | May 2006 | IBBQ vs IHE | |
| iShares Neuroscience and Healthcare ETF | 93 | 5.85M | Aug 2022 | IBBQ vs IBRN |
Top Performing IBBQ Alternatives (YTD)
IBBQ is at 15.12% YTD. There are 23 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 40.11%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| ARK Genomic Revolution Multi-Sector ETF | 40.11% | 1.31B | Oct 2014 | IBBQ vs ARKG | |
| AdvisorShares Psychedelics ETF | 35.29% | 44.37M | Sep 2021 | IBBQ vs PSIL | |
| Roundhill UNH WeeklyPay ETF | 34.33% | 6.01M | Dec 2025 | IBBQ vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 33.14% | 57.56M | Dec 2014 | IBBQ vs BBC | |
| ALPS Medical Breakthroughs ETF | 27.56% | 213.08M | Dec 2014 | IBBQ vs SBIO |
Lowest Volatility Alternatives to IBBQ
IBBQ has 20.34% 1-year volatility. There are 34 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | IBBQ vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IBBQ vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.64% | 10.11M | Jun 2007 | IBBQ vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.87% | 16.78M | Jul 2025 | IBBQ vs XLVI | |
| Milliman Healthcare Inflation Plus ETF | 11.73% | 982.35K | Apr 2026 | IBBQ vs MHIP |
Lowest Drawdown Alternatives to IBBQ
IBBQ has a 1-year max drawdown of -8.34%. There are 3 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | IBBQ vs GERM | |
| Horizon Kinetics SPAC Active ETF | -4.32% | 10.11M | Jun 2007 | IBBQ vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 36.36M | Sep 2016 | IBBQ vs FTXH | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 1.34B | May 2006 | IBBQ vs IHE | |
| iShares Neuroscience and Healthcare ETF | -8.80% | 5.85M | Aug 2022 | IBBQ vs IBRN |
Other ETFs from Invesco
The 10 most viewed Invesco ETFs shown here include QQQ, SPMO, QQQM and span 12 categories. AUM among these funds goes as high as $481B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Invesco QQQ ETF | Nasdaq-100 | 58 | 16.13% | 481.14B | Mar 1999 | IBBQ vs QQQ | |
| Invesco S&P 500 Momentum ETF | Momentum, S&P 500 | 62 | 26.03% | 22.01B | Oct 2015 | IBBQ vs SPMO | |
| Invesco NASDAQ 100 ETF | Nasdaq-100 | 59 | 16.16% | 100.59B | Oct 2020 | IBBQ vs QQQM | |
| Invesco S&P 500 Equal Weight ETF | S&P 500, Equal Weight | 58 | 12.75% | 96.24B | Apr 2003 | IBBQ vs RSP | |
| Invesco PHLX Semiconductor ETF | Semiconductors, Technology Equities | 92 | 74.43% | 2.58B | Jun 2021 | IBBQ vs SOXQ | |
| Invesco S&P 500 Top 50 ETF | S&P 500 | 40 | 3.75% | 10.85B | May 2005 | IBBQ vs XLG | |
| Invesco S&P 500 Quality ETF | S&P 500, Large Cap Blend Equities | 65 | 16.39% | 20.11B | Dec 2005 | IBBQ vs SPHQ | |
| Invesco S&P 500® High Dividend Low Volatility ETF | Dividend, S&P 500, Large Cap Value Equities | 37 | 11.46% | 3.29B | Oct 2012 | IBBQ vs SPHD | |
| Invesco S&P MidCap Momentum ETF | Momentum, Mid Cap Growth Equities | 50 | 14.98% | 7.45B | Mar 2005 | IBBQ vs XMMO | |
| Invesco Aerospace & Defense ETF | Aerospace & Defense, Industrials Equities | 35 | 9.54% | 8.22B | Oct 2005 | IBBQ vs PPA |
Often Compared With IBBQ
Investors most often compare IBBQ with IBB, BBH, GNOM. These 20 comparison targets span 3 categories, based on PortfoliosLab usage data.
Compare IBBQ with Any Fund or Stock
Compare IBBQ with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair IBBQ with funds that move differently
Invesco Nasdaq Biotechnology ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to IBBQ.
Explore IBBQ Diversifiers