IBBQ vs. SBIO

Last updated Jun 3, 2026

IBBQ (Invesco Nasdaq Biotechnology ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - IBBQ tracks the NASDAQ / Biotechnology while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 3 years, IBBQ returned 11.95%/yr vs 17.25%/yr for SBIO. Their correlation of 0.86 suggests significant overlap in exposure. IBBQ charges 0.00%/yr vs 0.50%/yr for SBIO.

Performance

IBBQ vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Invesco Nasdaq Biotechnology ETF (IBBQ) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, IBBQ achieves a 0.14% return, which is significantly higher than SBIO's -1.78% return.

IBBQ

• 1D: -2.91%
• 1M: -1.52%
• YTD: 0.14%
• 6M: 1.13%
• 1Y: 38.35%
• 3Y*: 11.95%
• 5Y*: —
• 10Y*: —

SBIO

• 1D: -4.73%
• 1M: -6.02%
• YTD: -1.78%
• 6M: 5.47%
• 1Y: 67.29%
• 3Y*: 17.25%
• 5Y*: 2.56%
• 10Y*: 7.86%

*Multi-year figures are annualized to reflect compound growth (CAGR)

IBBQ vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
IBBQ Invesco Nasdaq Biotechnology ETF	0.14%	33.32%	-0.63%	4.73%	-10.41%	-6.72%
SBIO ALPS Medical Breakthroughs ETF	-1.78%	55.07%	3.81%	8.68%	-28.08%	-15.20%

Correlation

The correlation between IBBQ and SBIO is 0.83, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.83
Correlation (3Y) Calculated over the trailing 3-year period	0.84
Correlation (All Time) Calculated using the full available price history since Jun 14, 2021	0.86

The correlation between IBBQ and SBIO has been stable across timeframes, ranging from 0.83 to 0.86 - a consistent structural relationship.

IBBQ vs. SBIO - Sectors Allocation Comparison

Sectors	IBBQ	SBIO
Healthcare	98.3%	100.0%
Financial Services	0.0%	-0.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

IBBQ vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

IBBQ

IBBQ Risk / Return Rank: 67
IBBQ Sharpe Ratio Rank: 58
IBBQ Sortino Ratio Rank: 58
IBBQ Omega Ratio Rank: 52
IBBQ Calmar Ratio Rank: 86
IBBQ Martin Ratio Rank: 80

SBIO

SBIO Risk / Return Rank: 74
SBIO Sharpe Ratio Rank: 69
SBIO Sortino Ratio Rank: 68
SBIO Omega Ratio Rank: 60
SBIO Calmar Ratio Rank: 90
SBIO Martin Ratio Rank: 84

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

IBBQ vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Invesco Nasdaq Biotechnology ETF (IBBQ) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	IBBQ	SBIO	Difference
Sharpe ratio Return per unit of total volatility	1.97	2.30	-0.33
Sortino ratio Return per unit of downside risk	2.78	3.17	-0.39
Omega ratio Gain probability vs. loss probability	1.33	1.37	-0.04
Calmar ratio Return relative to maximum drawdown	4.89	5.74	-0.86
Martin ratio Return relative to average drawdown	16.17	17.50	-1.33
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

IBBQ vs. SBIO - Sharpe Ratio Comparison

The current IBBQ Sharpe Ratio is 1.97, which is comparable to the SBIO Sharpe Ratio of 2.30. The chart below compares the historical Sharpe Ratios of IBBQ and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	IBBQ	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.97	2.30	-0.33
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.08	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.24	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.14	0.21	-0.07

Drawdowns

IBBQ vs. SBIO - Drawdown Comparison

The maximum IBBQ drawdown since its inception was -37.94%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for IBBQ and SBIO.

Drawdown Indicators

	IBBQ	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-37.94%	-63.06%	+25.12%
Max Drawdown (1Y) Largest decline over 1 year	-8.34%	-12.66%	+4.32%
Max Drawdown (3Y) Largest decline over 3 years	-23.66%	-42.44%	+18.78%
Max Drawdown (5Y) Largest decline over 5 years	—	-53.10%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	-6.82%	-17.95%	+11.13%
Average Drawdown Average peak-to-trough decline	-16.83%	-28.45%	+11.62%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.52%	4.15%	-1.63%

Volatility

IBBQ vs. SBIO - Volatility Comparison

The current volatility for Invesco Nasdaq Biotechnology ETF (IBBQ) is 6.88%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 9.94%. This indicates that IBBQ experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	IBBQ	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.88%	9.94%	-3.06%
Volatility (6M) Calculated over the trailing 6-month period	15.21%	22.86%	-7.65%
Volatility (1Y) Calculated over the trailing 1-year period	19.63%	29.55%	-9.92%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	21.85%	33.55%	-11.70%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	21.85%	33.18%	-11.33%

IBBQ vs. SBIO - Expense Ratio Comparison

IBBQ has a 0.00% expense ratio, which is lower than SBIO's 0.50% expense ratio.

Dividends

IBBQ vs. SBIO - Dividend Comparison

IBBQ's dividend yield for the trailing twelve months is around 0.88%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
IBBQ Invesco Nasdaq Biotechnology ETF	0.88%	0.90%	1.14%	0.81%	0.76%	0.63%	0.00%	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%

Frequently Asked Questions

Can I hold both IBBQ and SBIO in my portfolio?

IBBQ and SBIO have a correlation of 0.83, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, IBBQ or SBIO?

SBIO has higher volatility (9.94%) compared to IBBQ (6.88%). In terms of maximum drawdown, IBBQ dropped -37.94% vs SBIO's -63.06%.

Which ETF is better, IBBQ or SBIO?

On 3-year performance, SBIO leads with 17.25% vs 11.95% for IBBQ. On fees, IBBQ is cheaper at 0.00% per year. On volatility, IBBQ has been the lower-risk option at 6.88%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, IBBQ or SBIO?

Over the 3-year period, SBIO has performed better with a 17.25% return vs 11.95%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, IBBQ or SBIO?

IBBQ is cheaper with a 0.00% expense ratio, compared with 0.50% for SBIO.

Which ETF pays a higher dividend yield, IBBQ or SBIO?

IBBQ has the higher dividend yield at 0.88%, compared with 0.00% for SBIO.

What is the main difference between IBBQ and SBIO?

IBBQ tracks NASDAQ / Biotechnology, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: Invesco and SS&C. Their fees differ too: 0.00% for IBBQ and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (2.30 vs 1.97), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.