Fidelity Disruptive Medicine ETF (FMED) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with FMED. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to FMED
FMED charges 0.50% annually. There are 24 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.85B | Oct 2013 | FMED vs FHLC | |
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.66B | Dec 1998 | FMED vs XLV | |
| Vanguard Health Care ETF | 0.10% | 18.50B | Jan 2004 | FMED vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | FMED vs PBPH | |
| Invesco S&P SmallCap Health Care ETF | 0.29% | 131.36M | Apr 2010 | FMED vs PSCH |
Best Risk-Adjusted Alternatives to FMED
FMED has a PortfoliosLab risk / return rank of 12. There are 47 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 90.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 90 | 43.63M | Dec 2014 | FMED vs BBC | |
| SPDR S&P Biotech ETF | 75 | 8.28B | Feb 2006 | FMED vs XBI | |
| ALPS Medical Breakthroughs ETF | 74 | 161.79M | Dec 2014 | FMED vs SBIO | |
| iShares U.S. Pharmaceuticals ETF | 72 | 912.87M | May 2006 | FMED vs IHE | |
| Tema Oncology ETF | 70 | 142.24M | Aug 2023 | FMED vs CANC |
Top Performing FMED Alternatives (YTD)
FMED is at -9.30% YTD. There are 52 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 23.33%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| AdvisorShares Psychedelics ETF | 23.33% | 35.56M | Sep 2021 | FMED vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 17.36% | 1.24B | Oct 2014 | FMED vs ARKG | |
| Roundhill UNH WeeklyPay ETF | 15.01% | 4.48M | Dec 2025 | FMED vs UNHW | |
| iShares Genomics Immunology and Healthcare ETF Gen... | 9.51% | 163.14M | Jun 2019 | FMED vs IDNA | |
| Virtus LifeSci Biotech Clinical Trials ETF | 8.17% | 43.63M | Dec 2014 | FMED vs BBC |
Lowest Volatility Alternatives to FMED
FMED has 18.59% 1-year volatility. There are 28 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Principal Healthcare Innovators Index ETF | 0.00% | 16.16M | Aug 2016 | FMED vs BTEC | |
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | FMED vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | FMED vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.80% | 10.01M | Jun 2007 | FMED vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 10.94% | 14.25M | Jul 2025 | FMED vs XLVI |
Lowest Drawdown Alternatives to FMED
FMED has a 1-year max drawdown of -18.33%. There are 46 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | FMED vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.30% | 10.01M | Jun 2007 | FMED vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 35.04M | Sep 2016 | FMED vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 67.37M | Jun 2021 | FMED vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 912.87M | May 2006 | FMED vs IHE |
Other ETFs from Fidelity
The 10 most viewed Fidelity ETFs shown here include FTEC, FDVV, FBTC and span 7 categories. AUM among these funds goes as high as $26B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Fidelity MSCI Information Technology Index ETF | Technology Equities | 82 | 33.89% | 17.89B | Oct 2013 | FMED vs FTEC | |
| Fidelity High Dividend ETF | Large Cap Blend Equities, Dividend | 72 | 9.62% | 9.18B | Sep 2016 | FMED vs FDVV | |
| Fidelity Wise Origin Bitcoin Fund | Cryptocurrency | 2 | -23.31% | 14.17B | Jan 2024 | FMED vs FBTC | |
| Fidelity Total Bond ETF | Intermediate Core-Plus Bond | 41 | 0.70% | 25.56B | Oct 2014 | FMED vs FBND | |
| Fidelity Nasdaq Composite Index ETF | Large Cap Growth Equities | 74 | 17.15% | 10.01B | Sep 2003 | FMED vs ONEQ | |
| Fidelity Blue Chip Growth ETF | Large Cap Growth Equities | 63 | 16.81% | 6.21B | Jun 2020 | FMED vs FBCG | |
| Fidelity Enhanced Large Cap Core ETF | Large Cap Growth Equities | 75 | 11.89% | 7.04B | Apr 2007 | FMED vs FELC | |
| Fidelity MSCI Utilities Index ETF | Utilities Equities | 22 | 3.78% | 2.46B | Oct 2013 | FMED vs FUTY | |
| Fidelity Ethereum Fund | Cryptocurrency | 6 | -35.73% | 1.22B | Jul 2024 | FMED vs FETH | |
| Fidelity Enhanced Large Cap Growth ETF | Large Cap Growth Equities | 49 | 8.92% | 5.32B | Nov 2023 | FMED vs FELG |
Often Compared With FMED
Investors most often compare FMED with FDFF, FSMEX, XMMO. These 20 comparison targets span 12 categories, based on PortfoliosLab usage data.
Compare FMED with Any Fund or Stock
Compare FMED with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair FMED with funds that move differently
Fidelity Disruptive Medicine ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to FMED.
Explore FMED Diversifiers