Fidelity Disruptive Medicine ETF (FMED) belongs to the Health & Biotech Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with FMED. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to FMED
FMED charges 0.50% annually. There are 24 ETFs in the Health & Biotech Equities category with lower expense ratios, going as low as 0.08%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| State Street Health Care Select Sector SPDR ETF | 0.08% | 38.47B | Dec 1998 | FMED vs XLV | |
| Fidelity MSCI Health Care Index ETF | 0.08% | 2.99B | Oct 2013 | FMED vs FHLC | |
| Vanguard Health Care ETF | 0.09% | 19.00B | Jan 2004 | FMED vs VHT | |
| Portfolio Building Block World Pharma and Biotech ... | 0.13% | 9.98M | Nov 2025 | FMED vs PBPH | |
| GSK plc ADRhedged ETF | 0.19% | 793.18K | Jan 2025 | FMED vs GSKH |
Best Risk-Adjusted Alternatives to FMED
FMED has a PortfoliosLab risk / return rank of 19. There are 45 ETFs in the Health & Biotech Equities category with higher risk-adjusted ranks, going as high as 95.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Virtus LifeSci Biotech Clinical Trials ETF | 95 | 40.93M | Dec 2014 | FMED vs BBC | |
| ALPS Medical Breakthroughs ETF | 92 | 160.12M | Dec 2014 | FMED vs SBIO | |
| SPDR S&P Biotech ETF | 90 | 8.62B | Feb 2006 | FMED vs XBI | |
| iShares Neuroscience and Healthcare ETF | 89 | 5.39M | Aug 2022 | FMED vs IBRN | |
| First Trust Nasdaq Pharmaceuticals ETF | 87 | 33.60M | Sep 2016 | FMED vs FTXH |
Top Performing FMED Alternatives (YTD)
FMED is at -2.44% YTD. There are 50 ETFs in the Health & Biotech Equities category with higher YTD returns, going as high as 27.05%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| Roundhill UNH WeeklyPay ETF | 27.05% | 4.79M | Dec 2025 | FMED vs UNHW | |
| Virtus LifeSci Biotech Clinical Trials ETF | 25.75% | 40.93M | Dec 2014 | FMED vs BBC | |
| AdvisorShares Psychedelics ETF | 25.04% | 33.07M | Sep 2021 | FMED vs PSIL | |
| ARK Genomic Revolution Multi-Sector ETF | 24.30% | 1.31B | Oct 2014 | FMED vs ARKG | |
| SPDR S&P Biotech ETF | 20.70% | 8.62B | Feb 2006 | FMED vs XBI |
Lowest Volatility Alternatives to FMED
FMED has 19.27% 1-year volatility. There are 28 ETFs in the Health & Biotech Equities category with lower 1-year volatility, going as low as 0.00%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Loncar Cancer Immunotherapy ETF | 0.00% | 12.73M | Oct 2015 | FMED vs CNCR | |
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | FMED vs GERM | |
| Horizon Kinetics SPAC Active ETF | 8.65% | 10.10M | Jun 2007 | FMED vs SPAQ | |
| State Street Health Care Select Sector SPDR Premiu... | 11.06% | 14.95M | Jul 2025 | FMED vs XLVI | |
| Global X Aging Population ETF | 13.70% | 80.19M | May 2016 | FMED vs AGNG |
Lowest Drawdown Alternatives to FMED
FMED has a 1-year max drawdown of -18.33%. There are 46 ETFs in the Health & Biotech Equities category with shallower 1-year drawdowns, going as shallow as 0.00%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Amplify Treatments, Testing and Advancements ETF | 0.00% | 9.68M | Jun 2020 | FMED vs GERM | |
| Horizon Kinetics SPAC Active ETF | -5.00% | 10.10M | Jun 2007 | FMED vs SPAQ | |
| First Trust Nasdaq Pharmaceuticals ETF | -7.47% | 33.60M | Sep 2016 | FMED vs FTXH | |
| Invesco Nasdaq Biotechnology ETF | -8.34% | 68.94M | Jun 2021 | FMED vs IBBQ | |
| iShares U.S. Pharmaceuticals ETF | -8.47% | 956.44M | May 2006 | FMED vs IHE |
Other ETFs from Fidelity
The 10 most viewed Fidelity ETFs shown here include FTEC, FDVV, FBTC and span 7 categories. AUM among these funds goes as high as $26B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| Fidelity MSCI Information Technology Index ETF | Technology Equities | 60 | 23.56% | 21.38B | Oct 2013 | FMED vs FTEC | |
| Fidelity High Dividend ETF | Large Cap Blend Equities, Dividend | 64 | 8.39% | 9.77B | Sep 2016 | FMED vs FDVV | |
| Fidelity Wise Origin Bitcoin Fund | Cryptocurrency | 2 | -28.83% | 13.40B | Jan 2024 | FMED vs FBTC | |
| Fidelity Total Bond ETF | Intermediate Core-Plus Bond | 35 | 0.72% | 26.06B | Oct 2014 | FMED vs FBND | |
| Fidelity Nasdaq Composite Index ETF | Large Cap Growth Equities | 54 | 10.75% | 10.92B | Sep 2003 | FMED vs ONEQ | |
| Fidelity Blue Chip Growth ETF | Large Cap Growth Equities | 46 | 10.08% | 6.91B | Jun 2020 | FMED vs FBCG | |
| Fidelity Enhanced Large Cap Core ETF | Large Cap Blend Equities | 61 | 8.65% | 7.64B | Apr 2007 | FMED vs FELC | |
| Fidelity MSCI Utilities Index ETF | Utilities Equities | 28 | 6.83% | 2.35B | Oct 2013 | FMED vs FUTY | |
| Fidelity Ethereum Fund | Cryptocurrency | 6 | -44.11% | 994.18M | Jul 2024 | FMED vs FETH | |
| Fidelity Enhanced Large Cap Growth ETF | Large Cap Growth Equities | 32 | 2.26% | 5.76B | Nov 2023 | FMED vs FELG |
Often Compared With FMED
Investors most often compare FMED with FDFF, FSMEX, XMMO. These 20 comparison targets span 14 categories, based on PortfoliosLab usage data.
Compare FMED with Any Fund or Stock
Compare FMED with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair FMED with funds that move differently
Fidelity Disruptive Medicine ETF alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to FMED.
Explore FMED Diversifiers