FMED vs. GERM

Last updated Jun 3, 2026

FMED (Fidelity Disruptive Medicine ETF) and GERM (Amplify Treatments, Testing and Advancements ETF) are both Health & Biotech Equities funds. FMED is actively managed, while GERM is passively managed. Over the past year, FMED returned 4.49% vs 0.00% for GERM. FMED charges 0.50%/yr vs 0.68%/yr for GERM.

Performance

FMED vs. GERM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Fidelity Disruptive Medicine ETF (FMED) and Amplify Treatments, Testing and Advancements ETF (GERM). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

FMED

• 1D: -1.51%
• 1M: -0.65%
• YTD: -9.30%
• 6M: -12.64%
• 1Y: 4.49%
• 3Y*: —
• 5Y*: —
• 10Y*: —

GERM

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: 0.00%
• 1Y: 0.00%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

FMED vs. GERM - Yearly Performance Comparison

	2026 (YTD)	2025	2024
FMED Fidelity Disruptive Medicine ETF	-9.30%	9.69%	-3.00%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%

FMED vs. GERM - Sectors Allocation Comparison

Sectors	FMED	GERM
Healthcare	98.0%	99.3%
Technology	1.0%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	0.4%
Industrials	-	-
Real Estate	-	-
Utilities	-	-

Return for Risk

FMED vs. GERM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

FMED

FMED Risk / Return Rank: 12
FMED Sharpe Ratio Rank: 12
FMED Sortino Ratio Rank: 12
FMED Omega Ratio Rank: 12
FMED Calmar Ratio Rank: 11
FMED Martin Ratio Rank: 11

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

FMED vs. GERM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Fidelity Disruptive Medicine ETF (FMED) and Amplify Treatments, Testing and Advancements ETF (GERM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	FMED	GERM	Difference
Sharpe ratio Return per unit of total volatility	0.24	—	—
Sortino ratio Return per unit of downside risk	0.49	—	—
Omega ratio Gain probability vs. loss probability	1.05	—	—
Calmar ratio Return relative to maximum drawdown	0.27	—	—
Martin ratio Return relative to average drawdown	0.62	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	FMED	GERM	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.24	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.05	—	—

Drawdowns

FMED vs. GERM - Drawdown Comparison

The maximum FMED drawdown since its inception was -21.84%, which is greater than GERM's maximum drawdown of 0.00%. Use the drawdown chart below to compare losses from any high point for FMED and GERM.

Drawdown Indicators

	FMED	GERM	Difference
Max Drawdown Largest peak-to-trough decline	-21.84%	0.00%	-21.84%
Max Drawdown (1Y) Largest decline over 1 year	-18.33%	0.00%	-18.33%
Current Drawdown Current decline from peak	-14.91%	0.00%	-14.91%
Average Drawdown Average peak-to-trough decline	-7.03%	0.00%	-7.03%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.90%	0.00%	+7.90%

Volatility

FMED vs. GERM - Volatility Comparison

Fidelity Disruptive Medicine ETF (FMED) has a higher volatility of 5.65% compared to Amplify Treatments, Testing and Advancements ETF (GERM) at 0.00%. This indicates that FMED's price experiences larger fluctuations and is considered to be riskier than GERM based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	FMED	GERM	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.65%	0.00%	+5.65%
Volatility (6M) Calculated over the trailing 6-month period	14.21%	0.00%	+14.21%
Volatility (1Y) Calculated over the trailing 1-year period	18.59%	0.00%	+18.59%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	18.39%	0.00%	+18.39%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	18.39%	0.00%	+18.39%

FMED vs. GERM - Expense Ratio Comparison

FMED has a 0.50% expense ratio, which is lower than GERM's 0.68% expense ratio.

Dividends

FMED vs. GERM - Dividend Comparison

Neither FMED nor GERM has paid dividends to shareholders.

Position	TTM	2025	2024
FMED Fidelity Disruptive Medicine ETF	0.00%	0.00%	0.46%
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%

Frequently Asked Questions

Which is riskier, FMED or GERM?

FMED has higher volatility (5.65%) compared to GERM (0.00%). In terms of maximum drawdown, FMED dropped -21.84% vs GERM's 0.00%.

Which ETF is better, FMED or GERM?

On 1-year performance, FMED leads with 4.49% vs 0.00% for GERM. On fees, FMED is cheaper at 0.50% per year. On volatility, GERM has been the lower-risk option at 0.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, FMED or GERM?

Over the 1-year period, FMED has performed better with a 4.49% return vs 0.00%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, FMED or GERM?

FMED is cheaper with a 0.50% expense ratio, compared with 0.68% for GERM.

Which ETF pays a higher dividend yield, FMED or GERM?

FMED and GERM have nearly identical dividend yields, around 0.00%.

What is the main difference between FMED and GERM?

They also come from different issuers: Fidelity and Amplify. Their fees differ too: 0.50% for FMED and 0.68% for GERM.