FMED vs. XLVI

Last updated Jun 3, 2026

FMED (Fidelity Disruptive Medicine ETF) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - FMED is a Health & Biotech Equities fund actively managed by Fidelity, while XLVI is a Derivative Income fund actively managed by State Street. Both are actively managed. A 0.61 correlation means they provide meaningful diversification when combined. FMED charges 0.50%/yr vs 0.35%/yr for XLVI.

Performance

FMED vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Fidelity Disruptive Medicine ETF (FMED) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, FMED achieves a -9.30% return, which is significantly lower than XLVI's -1.33% return.

FMED

• 1D: -1.51%
• 1M: -0.65%
• YTD: -9.30%
• 6M: -12.64%
• 1Y: 4.49%
• 3Y*: —
• 5Y*: —
• 10Y*: —

XLVI

• 1D: -0.73%
• 1M: 1.42%
• YTD: -1.33%
• 6M: 0.46%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

FMED vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
FMED Fidelity Disruptive Medicine ETF	-9.30%	12.86%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	-1.33%	12.79%

Correlation

The correlation between FMED and XLVI is 0.61, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (All Time) Calculated using the full available price history since Jul 31, 2025	0.61

FMED vs. XLVI - Sectors Allocation Comparison

Sectors	FMED	XLVI
Healthcare	98.0%	-
Technology	1.0%	-
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	100.6%
Industrials	-	-
Real Estate	-	-
Utilities	-	-

Return for Risk

FMED vs. XLVI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

FMED

FMED Risk / Return Rank: 12
FMED Sharpe Ratio Rank: 12
FMED Sortino Ratio Rank: 12
FMED Omega Ratio Rank: 12
FMED Calmar Ratio Rank: 11
FMED Martin Ratio Rank: 11

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

FMED vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Fidelity Disruptive Medicine ETF (FMED) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	FMED	XLVI	Difference
Sharpe ratio Return per unit of total volatility	0.24	—	—
Sortino ratio Return per unit of downside risk	0.49	—	—
Omega ratio Gain probability vs. loss probability	1.05	—	—
Calmar ratio Return relative to maximum drawdown	0.27	—	—
Martin ratio Return relative to average drawdown	0.62	—	—
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

Sharpe Ratios by Period

	FMED	XLVI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.24	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.05	1.25	-1.29

Drawdowns

FMED vs. XLVI - Drawdown Comparison

The maximum FMED drawdown since its inception was -21.84%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for FMED and XLVI.

Drawdown Indicators

	FMED	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	-21.84%	-8.14%	-13.70%
Max Drawdown (1Y) Largest decline over 1 year	-18.33%	—	—
Current Drawdown Current decline from peak	-14.91%	-4.66%	-10.25%
Average Drawdown Average peak-to-trough decline	-7.03%	-1.94%	-5.09%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.90%	—	—

Volatility

Volatility by Period

	FMED	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.65%	—	—
Volatility (6M) Calculated over the trailing 6-month period	14.21%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	18.59%	10.94%	+7.65%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	18.39%	10.94%	+7.45%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	18.39%	10.94%	+7.45%

FMED vs. XLVI - Expense Ratio Comparison

FMED has a 0.50% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

FMED vs. XLVI - Dividend Comparison

FMED has not paid dividends to shareholders, while XLVI's dividend yield for the trailing twelve months is around 11.61%.

Position	TTM	2025	2024
FMED Fidelity Disruptive Medicine ETF	0.00%	0.00%	0.46%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.61%	5.73%	0.00%

Frequently Asked Questions

Can I hold both FMED and XLVI in my portfolio?

FMED and XLVI have a correlation of 0.61, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, FMED or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, FMED or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.50% for FMED.

Which ETF pays a higher dividend yield, FMED or XLVI?

XLVI has the higher dividend yield at 11.61%, compared with 0.00% for FMED.

What is the main difference between FMED and XLVI?

FMED is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: Fidelity and State Street. Their fees differ too: 0.50% for FMED and 0.35% for XLVI.