ProShares UltraShort Nasdaq Biotechnology (BIS) belongs to the Leveraged Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with BIS. Use the tables to find lower-cost options, better risk-adjusted returns, or a closer substitute for your current allocation.
Cheapest Alternatives to BIS
BIS charges 0.95% annually. There are 100 ETFs in the Leveraged Equities category with lower expense ratios, going as low as 0.35%.
| Symbol | Name | Expense Ratio | AUM | Inception | |
|---|---|---|---|---|---|
| WisdomTree Efficient U.S. Plus International Equit... | 0.35% | 44.22M | Mar 2026 | BIS vs NTSD | |
| ETRACS IFED Invest with the Fed TR Index ETN | 0.45% | 49.31M | Sep 2021 | BIS vs IFED | |
| Direxion Daily S&P 500 Bull 2X ETF | 0.60% | 257.66M | May 2014 | BIS vs SPUU | |
| Leverage Shares 2X Long TSLA Daily ETF | 0.75% | — | Dec 2024 | BIS vs TSLG | |
| Leverage Shares 2X Long BMNR Daily ETF | 0.75% | 25.41M | Oct 2025 | BIS vs BMNG |
Best Risk-Adjusted Alternatives to BIS
BIS has a PortfoliosLab risk / return rank of 1. There are 265 ETFs in the Leveraged Equities category with higher risk-adjusted ranks, going as high as 99.
| Symbol | Name | Risk / Return Rank | AUM | Inception | |
|---|---|---|---|---|---|
| Direxion Daily MU Bull 2X Shares | 99 | 6.16B | Oct 2024 | BIS vs MUU | |
| GraniteShares 2x Long MU Daily ETF | 98 | 923.53M | Nov 2024 | BIS vs MULL | |
| Innovator U.S. Equity Accelerated Plus ETF | 98 | 22.82M | Apr 2021 | BIS vs XTAP | |
| Innovator Growth Accelerated Plus ETF - April | 97 | 20.50M | Apr 2021 | BIS vs QTAP | |
| GraniteShares 2x Long INTC Daily ETF | 96 | 509.42M | Feb 2025 | BIS vs INTW |
Top Performing BIS Alternatives (YTD)
BIS is at -27.05% YTD. There are 244 ETFs in the Leveraged Equities category with higher YTD returns, going as high as 738.32%.
| Symbol | Name | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|
| GraniteShares 2x Long DELL Daily ETF | 738.32% | 162.40M | Feb 2025 | BIS vs DLLL | |
| Direxion Daily MU Bull 2X Shares | 575.80% | 6.16B | Oct 2024 | BIS vs MUU | |
| GraniteShares 2x Long MU Daily ETF | 555.59% | 923.53M | Nov 2024 | BIS vs MULL | |
| Direxion Daily INTC Bull 2X Shares | 395.01% | 101.49M | Nov 2025 | BIS vs LINT | |
| GraniteShares 2x Long INTC Daily ETF | 394.65% | 509.42M | Feb 2025 | BIS vs INTW |
Lowest Volatility Alternatives to BIS
BIS has 41.05% 1-year volatility. There are 84 ETFs in the Leveraged Equities category with lower 1-year volatility, going as low as 4.77%.
| Symbol | Name | Volatility 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Innovator U.S. Equity Accelerated Plus ETF | 4.77% | 22.82M | Apr 2021 | BIS vs XTAP | |
| Innovator Growth Accelerated Plus ETF - April | 6.21% | 20.50M | Apr 2021 | BIS vs QTAP | |
| Innovator U.S. Equity Accelerated Plus ETF - July | 7.40% | 13.45M | Jul 2021 | BIS vs XTJL | |
| Innovator Growth Accelerated Plus ETF - July | 10.50% | 20.95M | Jul 2021 | BIS vs QTJL | |
| Innovator US Equity Accelerated ETF | 10.55% | 69.49M | Apr 2021 | BIS vs XDSQ |
Lowest Drawdown Alternatives to BIS
BIS has a 1-year max drawdown of -60.93%. There are 178 ETFs in the Leveraged Equities category with shallower 1-year drawdowns, going as shallow as -1.72%.
| Symbol | Name | Max Drawdown 1Y | AUM | Inception | |
|---|---|---|---|---|---|
| Innovator U.S. Equity Accelerated Plus ETF | -1.72% | 22.82M | Apr 2021 | BIS vs XTAP | |
| Innovator Growth Accelerated Plus ETF - April | -2.49% | 20.50M | Apr 2021 | BIS vs QTAP | |
| Innovator U.S. Equity Accelerated Plus ETF - July | -5.12% | 13.45M | Jul 2021 | BIS vs XTJL | |
| Innovator Growth Accelerated Plus ETF - July | -6.68% | 20.95M | Jul 2021 | BIS vs QTJL | |
| Innovator US Equity Accelerated ETF | -9.60% | 69.49M | Apr 2021 | BIS vs XDSQ |
Other ETFs from ProShares
The 10 most viewed ProShares ETFs shown here include TQQQ, QLD, BITO and span 10 categories. AUM among these funds goes as high as $37B.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | AUM | Inception | |
|---|---|---|---|---|---|---|---|
| ProShares UltraPro QQQ | Leveraged Equities | 48 | 38.33% | 37.04B | Feb 2010 | BIS vs TQQQ | |
| ProShares Ultra QQQ | Leveraged Equities | 50 | 28.12% | 14.15B | Jun 2006 | BIS vs QLD | |
| ProShares Bitcoin Strategy ETF | Cryptocurrency | 1 | -30.09% | 1.45B | Oct 2021 | BIS vs BITO | |
| ProShares UltraPro S&P 500 | Leveraged Equities, S&P 500 | 52 | 23.85% | 5.47B | Jun 2009 | BIS vs UPRO | |
| ProShares Ultra S&P500 | Leveraged Equities, S&P 500 | 54 | 17.32% | 8.13B | Jun 2006 | BIS vs SSO | |
| ProShares Ultra Semiconductors | Leveraged Equities, Semiconductors | 70 | 70.32% | 2.97B | Jan 2007 | BIS vs USD | |
| ProShares S&P 500 Dividend Aristocrats ETF | Dividend, S&P 500, Large Cap Value Equities | 37 | 10.60% | 11.63B | Oct 2013 | BIS vs NOBL | |
| ProShares UltraPro Short QQQ | Leveraged Equities, Inverse Equities, Nasdaq-100 | 1 | -40.27% | 2.09B | Feb 2010 | BIS vs SQQQ | |
| ProShares Nasdaq-100 High Income ETF | Nasdaq-100, Derivative Income, Dividend | 54 | 13.67% | 410.75M | Mar 2024 | BIS vs IQQQ | |
| ProShares Ultra VIX Short-Term Futures ETF | Volatility | 2 | -32.31% | 216.19M | Oct 2011 | BIS vs UVXY |
Often Compared With BIS
Investors most often compare BIS with BIB, RSPN, IBBQ. These 20 comparison targets span 10 categories, based on PortfoliosLab usage data.
Compare BIS with Any Fund or Stock
Compare BIS with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.
Pair BIS with funds that move differently
ProShares UltraShort Nasdaq Biotechnology alternatives help with substitution. Diversifiers are the next step when you want funds with lower historical correlation to BIS.
Explore BIS Diversifiers