ProShares UltraShort Nasdaq Biotechnology (BIS) Alternatives
ProShares UltraShort Nasdaq Biotechnology (BIS) belongs to the Leveraged Equities category. Below you'll find alternative ETFs from the same category, ranked by key criteria, plus funds that investors commonly compare with BIS. Use the tables to find lower-cost options, better risk-adjusted returns, or funds that fit a different role in your portfolio.
Cheapest Alternatives to BIS
BIS charges 0.95% annually. Among ETFs in the Leveraged Equities category, these options have the lowest expense ratios among BIS alternatives.
| Symbol | Name | Expense Ratio | Inception | |
|---|---|---|---|---|
| ETRACS IFED Invest with the Fed TR Index ETN | 0.45% | Sep 14, 2021 | BIS vs IFED | |
| Direxion Daily S&P 500 Bull 2x Shares | 0.64% | May 28, 2014 | BIS vs SPUU | |
| Leverage Shares 2X Long NVDA Daily ETF | 0.75% | Dec 12, 2024 | BIS vs NVDG | |
| Leverage Shares 2X Long AMD Daily ETF | 0.75% | Jan 24, 2025 | BIS vs AMDG | |
| Leverage Shares 2X Long HOOD Daily ETF | 0.75% | Mar 20, 2025 | BIS vs HOOG |
Best Risk-Adjusted Alternatives to BIS
Among ETFs in the Leveraged Equities category, these options rank highest on PortfoliosLab's risk-adjusted score, which accounts for volatility, drawdown, and return consistency over a 1-year period.
| Symbol | Name | Risk / Return Rank | Inception | |
|---|---|---|---|---|
| Direxion Daily South Korea Bull 3X Shares | 98 | Apr 10, 2013 | BIS vs KORU | |
| Direxion Daily MU Bull 2X Shares | 98 | Oct 9, 2024 | BIS vs MUU | |
| GraniteShares 2x Long MU Daily ETF | 98 | Nov 11, 2024 | BIS vs MULL | |
| Direxion Daily GOOGL Bull 2X Shares | 96 | Sep 6, 2022 | BIS vs GGLL | |
| Direxion Daily TSM Bull 2X Shares | 96 | Oct 3, 2024 | BIS vs TSMX |
Top Performing BIS Alternatives (YTD)
BIS alternatives from the Leveraged Equities category, sorted by year-to-date return.
| Symbol | Name | YTD Return | Inception | |
|---|---|---|---|---|
| MicroSectors U.S. Big Oil Index 3X Leveraged ETN | 168.34% | Apr 9, 2019 | BIS vs NRGU | |
| MicroSectors Energy 3X Leveraged ETN | 141.86% | Feb 16, 2023 | BIS vs WTIU | |
| Leverage Shares 2X Long TER Daily ETF | 102.79% | Nov 17, 2025 | BIS vs TERG | |
| Direxion Daily S&P Oil & Gas Exploration & Product... | 102.61% | Apr 1, 2020 | BIS vs GUSH | |
| ProShares Ultra Oil & Gas | 85.56% | Jan 30, 2007 | BIS vs DIG |
Lowest Volatility Alternatives to BIS
BIS alternatives from the Leveraged Equities category, sorted by annualized volatility over the past year.
| Symbol | Name | Volatility 1Y | Inception | |
|---|---|---|---|---|
| Innovator U.S. Equity Accelerated Plus ETF | 14.33% | Apr 1, 2021 | BIS vs XTAP | |
| Innovator Growth Accelerated Plus ETF - April | 16.31% | Apr 1, 2021 | BIS vs QTAP | |
| Roundhill BRKB WeeklyPay ETF | 17.95% | Jun 17, 2025 | BIS vs BRKW | |
| Innovator US Equity Accelerated ETF | 17.99% | Apr 1, 2021 | BIS vs XDSQ | |
| Innovator U.S. Equity Accelerated Plus ETF - July | 18.18% | Jul 1, 2021 | BIS vs XTJL |
Lowest Drawdown Alternatives to BIS
BIS alternatives from the Leveraged Equities category, sorted by maximum drawdown over the past year.
| Symbol | Name | Max Drawdown 1Y | Inception | |
|---|---|---|---|---|
| Innovator U.S. Equity Accelerated Plus ETF | -11.83% | Apr 1, 2021 | BIS vs XTAP | |
| Innovator Growth Accelerated Plus ETF - April | -12.04% | Apr 1, 2021 | BIS vs QTAP | |
| Innovator US Equity Accelerated ETF | -12.18% | Apr 1, 2021 | BIS vs XDSQ | |
| Innovator Growth Accelerated ETF - Quarterly | -12.64% | Apr 1, 2021 | BIS vs XDQQ | |
| Innovator U.S. Equity Accelerated Plus ETF - July | -13.81% | Jul 1, 2021 | BIS vs XTJL |
Other ETFs from ProShares
Most popular ProShares ETFs on PortfoliosLab, across asset classes.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | Inception | |
|---|---|---|---|---|---|---|
| ProShares UltraPro QQQ | Leveraged Equities, Leveraged | 50 | -20.81% | Feb 9, 2010 | BIS vs TQQQ | |
| ProShares Bitcoin Strategy ETF | Cryptocurrency, Actively Managed | 5 | -23.25% | Oct 19, 2021 | BIS vs BITO | |
| ProShares Ultra QQQ | Leveraged Equities, Leveraged | 57 | -13.35% | Jun 21, 2006 | BIS vs QLD | |
| ProShares UltraPro S&P 500 | Leveraged Equities, S&P 500 | 45 | -16.03% | Jun 23, 2009 | BIS vs UPRO | |
| ProShares Ultra S&P500 | Leveraged Equities, S&P 500 | 51 | -10.23% | Jun 19, 2006 | BIS vs SSO | |
| ProShares S&P 500 Dividend Aristocrats ETF | S&P 500, Dividend | 27 | 2.36% | Oct 9, 2013 | BIS vs NOBL | |
| ProShares Ultra Semiconductors | Leveraged Equities, Semiconductors | 90 | -8.58% | Jan 30, 2007 | BIS vs USD | |
| ProShares UltraPro Short QQQ | Leveraged Equities, Leveraged | 2 | 18.46% | Feb 9, 2010 | BIS vs SQQQ | |
| ProShares Ultra VIX Short-Term Futures ETF | Leveraged, Volatility | 5 | 45.56% | Oct 3, 2011 | BIS vs UVXY | |
| Proshares Ultra Bitcoin ETF | Cryptocurrency, Leveraged Cryptocurrency | 3 | -47.12% | Apr 1, 2024 | BIS vs BITU |
Often Compared With BIS
What investors most often compare with BIS, based on PortfoliosLab usage data.
| Symbol | Name | Category | Risk / Return Rank | YTD Return | Inception | |
|---|---|---|---|---|---|---|
| ProShares Ultra Nasdaq Biotechnology | Leveraged Equities, Leveraged | 81 | 2.18% | Apr 7, 2010 | BIS vs BIB | |
| Invesco S&P 500® Equal Weight Industrials ETF | Industrials Equities, S&P 500 | 58 | 1.89% | Jan 11, 2006 | BIS vs RSPN | |
| Invesco Nasdaq Biotechnology ETF | Health & Biotech Equities | 86 | 2.22% | Jun 11, 2021 | BIS vs IBBQ | |
| State Street Health Care Select Sector SPDR ETF | Health & Biotech Equities | 16 | -4.90% | Dec 16, 1998 | BIS vs XLV | |
| Nasdaq, Inc. | 57 | -12.32% | — | BIS vs NDAQ | ||
| Innovator IBD 50 ETF | Large Cap Growth Equities | 41 | -4.02% | Apr 9, 2015 | BIS vs FFTY | |
| AdvisorShares Ranger Equity Bear ETF | Inverse Equities, Actively Managed | 17 | 12.05% | Jan 26, 2011 | BIS vs HDGE | |
| Global X DAX Germany ETF | Europe Equities | 28 | -7.59% | Oct 22, 2014 | BIS vs DAX | |
| Vanguard Information Technology ETF | Technology Equities | 67 | -7.34% | Mar 25, 2004 | BIS vs VGT | |
| Invesco Dynamic Pharmaceuticals ETF | Health & Biotech Equities | 62 | -0.44% | Jun 23, 2005 | BIS vs PJP |
Compare BIS with Any Fund or Stock
Compare BIS with any ETF, mutual fund, or stock using PortfoliosLab's comparison tool.