BIS vs. XLV

Last updated Apr 2, 2026

Compare and contrast key facts about ProShares UltraShort Nasdaq Biotechnology (BIS) and State Street Health Care Select Sector SPDR ETF (XLV).

BIS and XLV are both exchange-traded funds (ETFs), meaning they are traded on stock exchanges and can be bought and sold throughout the day. BIS is a passively managed fund by ProShares that tracks the performance of the NASDAQ Biotechnology Index (-200%). It was launched on Apr 7, 2010. XLV is a passively managed fund by State Street that tracks the performance of the Health Care Select Sector Index. It was launched on Dec 16, 1998. Both BIS and XLV are passive ETFs, meaning that they are not actively managed but aim to replicate the performance of the underlying index as closely as possible.

Performance

BIS vs. XLV - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ProShares UltraShort Nasdaq Biotechnology (BIS) and State Street Health Care Select Sector SPDR ETF (XLV). The values are adjusted to include any dividend payments, if applicable.

BIS vs. XLV - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
BIS ProShares UltraShort Nasdaq Biotechnology	-7.72%	-45.95%	4.79%	-6.54%	-2.14%	-14.74%	-56.01%	-41.01%	5.14%	-36.98%
XLV State Street Health Care Select Sector SPDR ETF	-4.18%	14.50%	2.47%	2.07%	-2.08%	26.04%	13.30%	20.45%	6.28%	21.77%

Returns By Period

In the year-to-date period, BIS achieves a -7.72% return, which is significantly lower than XLV's -4.18% return. Over the past 10 years, BIS has underperformed XLV with an annualized return of -24.57%, while XLV has yielded a comparatively higher 9.80% annualized return.

BIS

• 1D: -1.62%
• 1M: 3.02%
• YTD: -7.72%
• 6M: -28.73%
• 1Y: -54.25%
• 3Y*: -22.09%
• 5Y*: -15.41%
• 10Y*: -24.57%

XLV

• 1D: 0.76%
• 1M: -6.43%
• YTD: -4.18%
• 6M: 3.83%
• 1Y: 4.90%
• 3Y*: 6.25%
• 5Y*: 6.59%
• 10Y*: 9.80%

*Multi-year figures are annualized to reflect compound growth (CAGR)

BIS vs. XLV - Expense Ratio Comparison

BIS has a 0.95% expense ratio, which is higher than XLV's 0.08% expense ratio.

BIS

ProShares UltraShort Nasdaq Biotechnology

XLV

State Street Health Care Select Sector SPDR ETF

Return for Risk

BIS vs. XLV — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

BIS

BIS Risk / Return Rank: 1
BIS Sharpe Ratio Rank: 0
BIS Sortino Ratio Rank: 0
BIS Omega Ratio Rank: 0
BIS Calmar Ratio Rank: 1
BIS Martin Ratio Rank: 3

XLV

XLV Risk / Return Rank: 18
XLV Sharpe Ratio Rank: 19
XLV Sortino Ratio Rank: 18
XLV Omega Ratio Rank: 18
XLV Calmar Ratio Rank: 17
XLV Martin Ratio Rank: 16

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

BIS vs. XLV - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ProShares UltraShort Nasdaq Biotechnology (BIS) and State Street Health Care Select Sector SPDR ETF (XLV). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	BIS	XLV	Difference
Sharpe ratio Return per unit of total volatility	-1.17	0.28	-1.45
Sortino ratio Return per unit of downside risk	-1.93	0.51	-2.44
Omega ratio Gain probability vs. loss probability	0.79	1.06	-0.28
Calmar ratio Return relative to maximum drawdown	-0.81	0.28	-1.08
Martin ratio Return relative to average drawdown	-1.11	0.58	-1.70
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

BIS vs. XLV - Sharpe Ratio Comparison

The current BIS Sharpe Ratio is -1.17, which is lower than the XLV Sharpe Ratio of 0.28. The chart below compares the historical Sharpe Ratios of BIS and XLV, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	BIS	XLV	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-1.17	0.28	-1.45
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.36	0.45	-0.81
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.53	0.59	-1.12
Sharpe Ratio (All Time) Calculated using the full available price history	-0.68	0.46	-1.14

Correlation

The correlation between BIS and XLV is -0.72. This indicates that the assets' prices tend to move in opposite directions. Negative correlation can be particularly beneficial for diversification and risk management, as one asset may offset the losses of the other during market fluctuations.

Dividends

BIS vs. XLV - Dividend Comparison

BIS's dividend yield for the trailing twelve months is around 4.99%, more than XLV's 1.70% yield.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
BIS ProShares UltraShort Nasdaq Biotechnology	4.99%	5.25%	3.73%	1.75%	0.00%	0.00%	0.45%	2.11%	0.37%	0.00%	0.00%	0.00%
XLV State Street Health Care Select Sector SPDR ETF	1.70%	1.60%	1.67%	1.59%	1.47%	1.33%	1.49%	2.17%	1.57%	1.47%	1.60%	1.43%

Drawdowns

BIS vs. XLV - Drawdown Comparison

The maximum BIS drawdown since its inception was -99.86%, which is greater than XLV's maximum drawdown of -39.17%. Use the drawdown chart below to compare losses from any high point for BIS and XLV.

Drawdown Indicators

	BIS	XLV	Difference
Max Drawdown Largest peak-to-trough decline	-99.86%	-39.17%	-60.69%
Max Drawdown (1Y) Largest decline over 1 year	-64.06%	-10.76%	-53.30%
Max Drawdown (5Y) Largest decline over 5 years	-73.87%	-17.11%	-56.76%
Max Drawdown (10Y) Largest decline over 10 years	-95.07%	-28.40%	-66.67%
Current Drawdown Current decline from peak	-99.85%	-7.41%	-92.44%
Average Drawdown Average peak-to-trough decline	-89.93%	-7.12%	-82.81%
Ulcer Index Depth and duration of drawdowns from previous peaks	46.44%	5.11%	+41.33%

Volatility

BIS vs. XLV - Volatility Comparison

ProShares UltraShort Nasdaq Biotechnology (BIS) has a higher volatility of 16.82% compared to State Street Health Care Select Sector SPDR ETF (XLV) at 4.79%. This indicates that BIS's price experiences larger fluctuations and is considered to be riskier than XLV based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	BIS	XLV	Difference
Volatility (1M) Calculated over the trailing 1-month period	16.82%	4.79%	+12.03%
Volatility (6M) Calculated over the trailing 6-month period	29.13%	10.29%	+18.84%
Volatility (1Y) Calculated over the trailing 1-year period	47.01%	17.73%	+29.28%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	43.50%	14.56%	+28.94%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	46.64%	16.53%	+30.11%