OPEN vs. KPTI
OPEN (Opendoor Technologies Inc.) and KPTI (Karyopharm Therapeutics Inc.) are both stocks. OPEN operates in Real Estate - Services (Real Estate), while KPTI operates in Biotechnology (Healthcare). Over the past 5 years, OPEN returned -24.01%/yr vs -43.70%/yr for KPTI. At a 0.29 correlation, their price movements are largely independent.
Performance
OPEN vs. KPTI - Performance Comparison
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Returns By Period
In the year-to-date period, OPEN achieves a -26.07% return, which is significantly lower than KPTI's 15.49% return.
OPEN
- 1D
- -2.49%
- 1M
- -13.97%
- YTD
- -26.07%
- 6M
- -38.87%
- 1Y
- 555.14%
- 3Y*
- 22.89%
- 5Y*
- -24.01%
- 10Y*
- —
KPTI
- 1D
- -6.39%
- 1M
- -1.62%
- YTD
- 15.49%
- 6M
- 44.31%
- 1Y
- 89.31%
- 3Y*
- -36.47%
- 5Y*
- -43.70%
- 10Y*
- -23.75%
OPEN vs. KPTI - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | |
|---|---|---|---|---|---|---|---|
OPEN Opendoor Technologies Inc. | -26.07% | 276.52% | -64.29% | 286.21% | -92.06% | -35.72% | 110.39% |
KPTI Karyopharm Therapeutics Inc. | 15.49% | -27.45% | -21.82% | -74.56% | -47.12% | -58.46% | -16.91% |
Correlation
The correlation between OPEN and KPTI is 0.08, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.08 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.24 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.30 |
Correlation (All Time) Calculated using the full available price history since Jun 19, 2020 | 0.29 |
Over the past year, the correlation between OPEN and KPTI has dropped to 0.08 - well below their long-term average of 0.29, suggesting their price drivers have been diverging.
Fundamentals
OPEN:
$4.13B
KPTI:
$210.08M
OPEN:
-$1.74
KPTI:
-$13.00
OPEN:
0.87
KPTI:
0.84
OPEN:
$3.94B
KPTI:
$151.12M
OPEN:
$312.00M
KPTI:
$145.13M
OPEN:
-$1.25B
KPTI:
-$93.05M
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Return for Risk
OPEN vs. KPTI — Risk / Return Rank
OPEN
KPTI
OPEN vs. KPTI - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Opendoor Technologies Inc. (OPEN) and Karyopharm Therapeutics Inc. (KPTI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| OPEN | KPTI | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +2.53 | ||
| Sortino ratioReturn per unit of downside risk | +2.08 | ||
| Omega ratioGain probability vs. loss probability | 1.47 | 1.22 | +0.24 |
| Calmar ratioReturn relative to maximum drawdown | 9.66 | 1.86 | +7.81 |
| Martin ratioReturn relative to average drawdown | 15.03 | 4.59 | +10.44 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| OPEN | KPTI | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 3.48 | 0.95 | +2.53 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.21 | -0.46 | +0.25 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | — | -0.28 | — |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.13 | -0.27 | +0.14 |
Drawdowns
OPEN vs. KPTI - Drawdown Comparison
The maximum OPEN drawdown since its inception was -98.57%, roughly equal to the maximum KPTI drawdown of -99.50%. Use the drawdown chart below to compare losses from any high point for OPEN and KPTI.
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Drawdown Indicators
| OPEN | KPTI | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -98.57% | -99.50% | +0.93% |
Max Drawdown (1Y)Largest decline over 1 year | -57.96% | -48.36% | -9.60% |
Max Drawdown (3Y)Largest decline over 3 years | -90.28% | -89.32% | -0.96% |
Max Drawdown (5Y)Largest decline over 5 years | -97.93% | -98.36% | +0.43% |
Max Drawdown (10Y)Largest decline over 10 years | — | -99.15% | — |
Current DrawdownCurrent decline from peak | -87.59% | -98.80% | +11.21% |
Average DrawdownAverage peak-to-trough decline | -74.59% | -75.28% | +0.69% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 37.43% | 19.53% | +17.90% |
Volatility
OPEN vs. KPTI - Volatility Comparison
The current volatility for Opendoor Technologies Inc. (OPEN) is 21.37%, while Karyopharm Therapeutics Inc. (KPTI) has a volatility of 24.86%. This indicates that OPEN experiences smaller price fluctuations and is considered to be less risky than KPTI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| OPEN | KPTI | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 21.37% | 24.86% | -3.49% |
Volatility (6M)Calculated over the trailing 6-month period | 52.74% | 62.32% | -9.58% |
Volatility (1Y)Calculated over the trailing 1-year period | 161.11% | 94.32% | +66.79% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 113.51% | 94.91% | +18.60% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 110.45% | 86.51% | +23.94% |
Dividends
OPEN vs. KPTI - Dividend Comparison
Neither OPEN nor KPTI has paid dividends to shareholders.
Financials
OPEN vs. KPTI - Financials Comparison
This section allows you to compare key financial metrics between Opendoor Technologies Inc. and Karyopharm Therapeutics Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
OPEN vs. KPTI - Profitability Comparison
OPEN - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Opendoor Technologies Inc. reported a gross profit of 72.00M and revenue of 720.00M. Therefore, the gross margin over that period was 10.0%.
KPTI - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported a gross profit of 33.72M and revenue of 35.07M. Therefore, the gross margin over that period was 96.2%.
OPEN - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Opendoor Technologies Inc. reported an operating income of -159.00M and revenue of 720.00M, resulting in an operating margin of -22.1%.
KPTI - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported an operating income of -26.76M and revenue of 35.07M, resulting in an operating margin of -76.3%.
OPEN - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Opendoor Technologies Inc. reported a net income of -173.00M and revenue of 720.00M, resulting in a net margin of -24.0%.
KPTI - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported a net income of -22.39M and revenue of 35.07M, resulting in a net margin of -63.9%.
Frequently Asked Questions
OPEN and KPTI have a correlation of 0.08, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
KPTI has higher volatility (24.86%) compared to OPEN (21.37%). In terms of maximum drawdown, OPEN dropped -98.57% vs KPTI's -99.50%.
OPEN currently has the higher Sharpe Ratio (3.48 vs 0.95), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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