NBIX vs. RVMD

Last updated Jun 16, 2026

NBIX (Neurocrine Biosciences, Inc.) and RVMD (Revolution Medicines, Inc.) are both stocks. Both are in the Healthcare sector — NBIX in Drug Manufacturers - Specialty & Generic, RVMD in Biotechnology. Over the past 5 years, NBIX returned 10.10%/yr vs 35.73%/yr for RVMD. At a 0.31 correlation, their price movements are largely independent.

Performance

NBIX vs. RVMD - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Neurocrine Biosciences, Inc. (NBIX) and Revolution Medicines, Inc. (RVMD). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, NBIX achieves a 12.47% return, which is significantly lower than RVMD's 100.95% return.

NBIX

• 1D: -0.16%
• 1M: 0.69%
• YTD: 12.47%
• 6M: 3.54%
• 1Y: 28.23%
• 3Y*: 17.79%
• 5Y*: 10.10%
• 10Y*: 13.68%

RVMD

• 1D: 4.02%
• 1M: 9.89%
• YTD: 100.95%
• 6M: 102.61%
• 1Y: 294.33%
• 3Y*: 86.64%
• 5Y*: 35.73%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

NBIX vs. RVMD - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
NBIX Neurocrine Biosciences, Inc.	12.47%	3.90%	3.60%	10.31%	40.24%	-11.14%	-10.94%
RVMD Revolution Medicines, Inc.	100.95%	82.10%	52.51%	20.40%	-5.36%	-36.42%	40.34%

Correlation

The correlation between NBIX and RVMD is 0.33, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.33
Correlation (3Y) Calculated over the trailing 3-year period	0.33
Correlation (5Y) Calculated over the trailing 5-year period	0.35
Correlation (All Time) Calculated using the full available price history since Feb 13, 2020	0.31

Fundamentals

Market Cap NBIX : $16.49B RVMD : $31.71B
EPS NBIX : $6.53 RVMD : -$7.17
PB Ratio NBIX : 4.84 RVMD : 21.14
Total Revenue (TTM) NBIX : $3.10B RVMD : $0.00
Gross Profit (TTM) NBIX : $3.05B RVMD : -$4.70M
EBITDA (TTM) NBIX : $881.20M RVMD : -$1.34B

Return for Risk

NBIX vs. RVMD — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

NBIX

NBIX Risk / Return Rank: 67
NBIX Sharpe Ratio Rank: 70
NBIX Sortino Ratio Rank: 65
NBIX Omega Ratio Rank: 66
NBIX Calmar Ratio Rank: 68
NBIX Martin Ratio Rank: 68

RVMD

RVMD Risk / Return Rank: 98
RVMD Sharpe Ratio Rank: 98
RVMD Sortino Ratio Rank: 99
RVMD Omega Ratio Rank: 98
RVMD Calmar Ratio Rank: 98
RVMD Martin Ratio Rank: 98

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

NBIX vs. RVMD - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Neurocrine Biosciences, Inc. (NBIX) and Revolution Medicines, Inc. (RVMD). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	NBIX	RVMD	Difference
Sharpe ratio: Return per unit of total volatility	0.90	4.41	-3.51
Sortino ratio: Return per unit of downside risk	1.39	5.59	-4.20
Omega ratio: Gain probability vs. loss probability	1.19	1.78	-0.59
Calmar ratio: Return relative to maximum drawdown	1.36	11.88	-10.53
Martin ratio: Return relative to average drawdown	2.98	28.48	-25.50

NBIX vs. RVMD - Sharpe Ratio Comparison

The current NBIX Sharpe Ratio is 0.90, which is lower than the RVMD Sharpe Ratio of 4.41. The chart below compares the historical Sharpe Ratios of NBIX and RVMD, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

NBIX vs. RVMD - Drawdown Comparison

The maximum NBIX drawdown since its inception was -97.21%, which is greater than RVMD's maximum drawdown of -73.29%. Use the drawdown chart below to compare losses from any high point for NBIX and RVMD.

Drawdown Indicators

	NBIX	RVMD	Difference
Max Drawdown Largest peak-to-trough decline	-97.21%	-73.29%	-23.92%
Max Drawdown (1Y) Largest decline over 1 year	-20.90%	-24.95%	+4.05%
Max Drawdown (3Y) Largest decline over 3 years	-42.89%	-48.63%	+5.74%
Max Drawdown (5Y) Largest decline over 5 years	-42.89%	-57.95%	+15.06%
Max Drawdown (10Y) Largest decline over 10 years	-46.39%	—	—
Current Drawdown Current decline from peak	-4.68%	-2.21%	-2.47%
Average Drawdown Average peak-to-trough decline	-43.83%	-35.66%	-8.17%
Ulcer Index Depth and duration of drawdowns from previous peaks	9.50%	10.57%	-1.07%

Volatility

NBIX vs. RVMD - Volatility Comparison

The current volatility for Neurocrine Biosciences, Inc. (NBIX) is 9.52%, while Revolution Medicines, Inc. (RVMD) has a volatility of 13.97%. This indicates that NBIX experiences smaller price fluctuations and is considered to be less risky than RVMD based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	NBIX	RVMD	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.52%	13.97%	-4.45%
Volatility (6M) Calculated over the trailing 6-month period	23.90%	55.20%	-31.30%
Volatility (1Y) Calculated over the trailing 1-year period	31.43%	67.30%	-35.87%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.73%	62.58%	-29.85%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	39.14%	65.75%	-26.61%

Dividends

NBIX vs. RVMD - Dividend Comparison

Neither NBIX nor RVMD has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both NBIX and RVMD in my portfolio?

NBIX and RVMD have a correlation of 0.33, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, NBIX or RVMD?

RVMD has higher volatility (13.97%) compared to NBIX (9.52%). In terms of maximum drawdown, NBIX dropped -97.21% vs RVMD's -73.29%.

Which has better risk-adjusted returns?

RVMD currently has the higher Sharpe Ratio (4.41 vs 0.90), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.