RVMD vs. SYRE

Last updated Jun 24, 2026

RVMD (Revolution Medicines, Inc.) and SYRE (Spyre Therapeutics Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, RVMD returned 38.97%/yr vs -11.25%/yr for SYRE. At a 0.30 correlation, their price movements are largely independent.

Performance

RVMD vs. SYRE - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Revolution Medicines, Inc. (RVMD) and Spyre Therapeutics Inc. (SYRE). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, RVMD achieves a 112.82% return, which is significantly lower than SYRE's 196.25% return.

RVMD

• 1D: 2.23%
• 1M: 11.84%
• YTD: 112.82%
• 6M: 111.17%
• 1Y: 323.35%
• 3Y*: 87.98%
• 5Y*: 38.97%
• 10Y*: —

SYRE

• 1D: -3.26%
• 1M: 31.06%
• YTD: 196.25%
• 6M: 192.06%
• 1Y: 561.10%
• 3Y*: 113.30%
• 5Y*: -11.25%
• 10Y*: -3.17%

*Multi-year figures are annualized to reflect compound growth (CAGR)

RVMD vs. SYRE - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
RVMD Revolution Medicines, Inc.	112.82%	82.10%	52.51%	20.40%	-5.36%	-36.42%	40.34%
SYRE Spyre Therapeutics Inc.	196.25%	40.72%	8.18%	91.33%	-90.53%	-39.64%	-7.19%

Correlation

The correlation between RVMD and SYRE is 0.35, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.35
Correlation (3Y) Calculated over the trailing 3-year period	0.37
Correlation (5Y) Calculated over the trailing 5-year period	0.30
Correlation (All Time) Calculated using the full available price history since Feb 13, 2020	0.30

Fundamentals

Market Cap RVMD : $33.58B SYRE : $33.58B
EPS RVMD : -$7.17 SYRE : -$0.88
PB Ratio RVMD : 22.39 SYRE : 64.04
Total Revenue (TTM) RVMD : $0.00 SYRE : $90.49M
Gross Profit (TTM) RVMD : -$4.70M SYRE : $0.00
EBITDA (TTM) RVMD : -$1.34B SYRE : -$171.29M

Return for Risk

RVMD vs. SYRE — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

RVMD

RVMD Risk / Return Rank: 98
RVMD Sharpe Ratio Rank: 99
RVMD Sortino Ratio Rank: 99
RVMD Omega Ratio Rank: 98
RVMD Calmar Ratio Rank: 98
RVMD Martin Ratio Rank: 98

SYRE

SYRE Risk / Return Rank: 99
SYRE Sharpe Ratio Rank: 100
SYRE Sortino Ratio Rank: 99
SYRE Omega Ratio Rank: 98
SYRE Calmar Ratio Rank: 100
SYRE Martin Ratio Rank: 100

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

RVMD vs. SYRE - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Revolution Medicines, Inc. (RVMD) and Spyre Therapeutics Inc. (SYRE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	RVMD	SYRE	Difference
Sharpe ratio: Return per unit of total volatility	4.85	8.24	-3.39
Sortino ratio: Return per unit of downside risk	5.85	6.24	-0.39
Omega ratio: Gain probability vs. loss probability	1.83	1.73	+0.09
Calmar ratio: Return relative to maximum drawdown	13.06	33.72	-20.66
Martin ratio: Return relative to average drawdown	31.28	94.51	-63.22

RVMD vs. SYRE - Sharpe Ratio Comparison

The current RVMD Sharpe Ratio is 4.85, which is lower than the SYRE Sharpe Ratio of 8.24. The chart below compares the historical Sharpe Ratios of RVMD and SYRE, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

RVMD vs. SYRE - Drawdown Comparison

The maximum RVMD drawdown since its inception was -73.29%, smaller than the maximum SYRE drawdown of -99.11%. Use the drawdown chart below to compare losses from any high point for RVMD and SYRE.

Drawdown Indicators

	RVMD	SYRE	Difference
Max Drawdown Largest peak-to-trough decline	-73.29%	-99.11%	+25.82%
Max Drawdown (1Y) Largest decline over 1 year	-24.95%	-16.79%	-8.16%
Max Drawdown (3Y) Largest decline over 3 years	-48.63%	-73.99%	+25.36%
Max Drawdown (5Y) Largest decline over 5 years	-56.85%	-98.74%	+41.89%
Max Drawdown (10Y) Largest decline over 10 years	—	-99.04%	—
Current Drawdown Current decline from peak	0.00%	-67.62%	+67.62%
Average Drawdown Average peak-to-trough decline	-35.55%	-62.69%	+27.14%
Ulcer Index Depth and duration of drawdowns from previous peaks	10.40%	5.98%	+4.42%

Volatility

RVMD vs. SYRE - Volatility Comparison

The current volatility for Revolution Medicines, Inc. (RVMD) is 14.00%, while Spyre Therapeutics Inc. (SYRE) has a volatility of 20.99%. This indicates that RVMD experiences smaller price fluctuations and is considered to be less risky than SYRE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	RVMD	SYRE	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.00%	20.99%	-6.99%
Volatility (6M) Calculated over the trailing 6-month period	55.27%	47.54%	+7.73%
Volatility (1Y) Calculated over the trailing 1-year period	67.19%	68.81%	-1.62%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	62.58%	179.28%	-116.70%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	65.68%	136.22%	-70.54%

Dividends

RVMD vs. SYRE - Dividend Comparison

Neither RVMD nor SYRE has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both RVMD and SYRE in my portfolio?

RVMD and SYRE have a correlation of 0.35, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, RVMD or SYRE?

SYRE has higher volatility (20.99%) compared to RVMD (14.00%). In terms of maximum drawdown, RVMD dropped -73.29% vs SYRE's -99.11%.

Which has better risk-adjusted returns?

SYRE currently has the higher Sharpe Ratio (8.23 vs 4.85), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.