NBIX vs. OPRX
NBIX (Neurocrine Biosciences, Inc.) and OPRX (OptimizeRx Corporation) are both stocks. Both are in the Healthcare sector — NBIX in Drug Manufacturers - Specialty & Generic, OPRX in Health Information Services. Over the past 10 years, NBIX returned 12.71%/yr vs 18.70%/yr for OPRX. Their 0.07 correlation means their historical movements had little consistent relationship.
Performance
NBIX vs. OPRX - Performance Comparison
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Returns By Period
In the year-to-date period, NBIX achieves a 17.61% return, which is significantly higher than OPRX's -50.65% return. Over the past 10 years, NBIX has underperformed OPRX with an annualized return of 12.71%, while OPRX has yielded a comparatively higher 18.70% annualized return.
NBIX
- 1D
- -10.08%
- 1M
- -0.58%
- 6M
- 22.59%
- YTD
- 17.61%
- 1Y
- 30.08%
- 3Y*
- 17.27%
- 5Y*
- 12.34%
- 10Y*
- 12.71%
- ALL TIME*
- 9.11%
OPRX
- 1D
- -3.51%
- 1M
- -0.49%
- 6M
- -43.77%
- YTD
- -50.65%
- 1Y
- -52.06%
- 3Y*
- -24.56%
- 5Y*
- -35.75%
- 10Y*
- 18.70%
- ALL TIME*
- 15.10%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $278.93M | $232.17M | $211.02M | |
| $1.30M | $1.68M | $2.32M |
NBIX vs. OPRX - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
NBIX Neurocrine Biosciences, Inc. | 17.61% | 3.90% | 3.60% | 10.31% | 40.24% | -11.14% | -10.83% | 50.53% | -7.96% | 100.49% |
OPRX OptimizeRx Corporation | -50.65% | 152.26% | -66.04% | -14.82% | -72.95% | 99.33% | 203.41% | -6.38% | 598.73% | 93.83% |
Correlation
The correlation between NBIX and OPRX is 0.24, which is low. Their historical price movements had little consistent relationship.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.24 |
Correlation (3Y) Balances recent behavior with more history. | 0.16 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.20 |
Correlation (10Y) Provides a long-term view across more market conditions. | 0.16 |
Correlation (All Time) Calculated using the full available price history since Jul 13, 2007 | 0.07 |
The correlation between NBIX and OPRX shifts across timeframes, from 0.07 (all time) to 0.24 (1 year), reflecting how their relationship changes across market environments.
Fundamentals
NBIX:
$16.77B
OPRX:
$113.53M
NBIX:
$6.84
OPRX:
$0.36
NBIX:
24.39
OPRX:
16.86
NBIX:
0.48
OPRX:
0.03
NBIX:
5.10
OPRX:
1.07
NBIX:
4.35
OPRX:
0.88
NBIX:
$3.37B
OPRX:
$107.35M
NBIX:
$3.31B
OPRX:
$70.86M
NBIX:
$940.50M
OPRX:
$16.55M
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Return for Risk
NBIX vs. OPRX — Risk / Return Rank
NBIX
OPRX
NBIX vs. OPRX - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Neurocrine Biosciences, Inc. (NBIX) and OptimizeRx Corporation (OPRX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| NBIX | OPRX | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +1.58 | ||
| Sortino ratioReturn per unit of downside risk | +2.19 | ||
| Omega ratioGain probability vs. loss probability | 1.19 | 0.90 | +0.29 |
| Calmar ratioReturn relative to maximum drawdown | 1.45 | -0.66 | +2.11 |
| Martin ratioReturn relative to average drawdown | 3.18 | -0.99 | +4.17 |
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Drawdowns
NBIX vs. OPRX - Drawdown Comparison
The maximum NBIX drawdown since its inception was -97.21%, roughly equal to the maximum OPRX drawdown of -99.32%. Use the drawdown chart below to compare losses from any high point for NBIX and OPRX.
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Drawdown Indicators
| NBIX | OPRX | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -97.21% | -99.32% | +2.11% |
Max Drawdown (1Y)Largest decline over 1 year | -20.90% | -79.06% | +58.16% |
Max Drawdown (3Y)Largest decline over 3 years | -42.89% | -79.06% | +36.17% |
Max Drawdown (5Y)Largest decline over 5 years | -42.89% | -96.10% | +53.21% |
Max Drawdown (10Y)Largest decline over 10 years | -46.39% | -96.10% | +49.71% |
Current DrawdownCurrent decline from peak | -10.08% | -93.83% | +83.75% |
Average DrawdownAverage peak-to-trough decline | -43.66% | -60.80% | +17.14% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 9.47% | 52.76% | -43.29% |
Volatility
NBIX vs. OPRX - Volatility Comparison
Neurocrine Biosciences, Inc. (NBIX) has a higher volatility of 14.12% compared to OptimizeRx Corporation (OPRX) at 9.79%. This indicates that NBIX's price experiences larger fluctuations and is considered to be riskier than OPRX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| NBIX | OPRX | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 14.12% | 9.79% | +4.33% |
Volatility (6M)Calculated over the trailing 6-month period | 26.01% | 53.13% | -27.12% |
Volatility (1Y)Calculated over the trailing 1-year period | 33.74% | 77.74% | -44.00% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 33.17% | 76.03% | -42.86% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 39.18% | 114.58% | -75.40% |
Dividends
NBIX vs. OPRX - Dividend Comparison
Neither NBIX nor OPRX has paid dividends to shareholders.
Financials
NBIX vs. OPRX - Financials Comparison
This section allows you to compare key financial metrics between Neurocrine Biosciences, Inc. and OptimizeRx Corporation. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
NBIX vs. OPRX - Profitability Comparison
NBIX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, Neurocrine Biosciences, Inc. reported a gross profit of 935.80M and revenue of 959.00M. Therefore, the gross margin over that period was 97.6%.
OPRX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Aug 2026, OptimizeRx Corporation reported a gross profit of 14.93M and revenue of 19.84M. Therefore, the gross margin over that period was 75.3%.
NBIX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, Neurocrine Biosciences, Inc. reported an operating income of 151.50M and revenue of 959.00M, resulting in an operating margin of 15.8%.
OPRX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Aug 2026, OptimizeRx Corporation reported an operating income of 396.00K and revenue of 19.84M, resulting in an operating margin of 2.0%.
NBIX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, Neurocrine Biosciences, Inc. reported a net income of 144.40M and revenue of 959.00M, resulting in a net margin of 15.1%.
OPRX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Aug 2026, OptimizeRx Corporation reported a net income of -495.00K and revenue of 19.84M, resulting in a net margin of -2.5%.
Frequently Asked Questions
NBIX and OPRX have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
NBIX has higher volatility (14.12%) compared to OPRX (9.79%). In terms of maximum drawdown, NBIX dropped -97.21% vs OPRX's -99.32%.
NBIX currently has the higher Sharpe Ratio (0.91 vs -0.67), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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