KPTI vs. RGTI
KPTI (Karyopharm Therapeutics Inc.) and RGTI (Rigetti Computing Inc) are both stocks. KPTI operates in Biotechnology (Healthcare), while RGTI operates in Computer Hardware (Technology). Over the past 5 years, KPTI returned -56.62%/yr vs 9.01%/yr for RGTI. Their 0.17 correlation means their historical movements had little consistent relationship.
Performance
KPTI vs. RGTI - Performance Comparison
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Returns By Period
In the year-to-date period, KPTI achieves a -73.91% return, which is significantly lower than RGTI's -32.51% return.
KPTI
- 1D
- -72.61%
- 1M
- -80.00%
- 6M
- -70.55%
- YTD
- -73.91%
- 1Y
- -51.15%
- 3Y*
- -58.57%
- 5Y*
- -56.62%
- 10Y*
- -32.96%
- ALL TIME*
- -32.15%
RGTI
- 1D
- 0.61%
- 1M
- -16.67%
- 6M
- -17.72%
- YTD
- -32.51%
- 1Y
- 5.88%
- 3Y*
- 66.31%
- 5Y*
- 9.01%
- 10Y*
- —
- ALL TIME*
- 8.13%
Liquidity Comparison
| Position | Avg. Volume Value (2W) | Avg. Volume Value (1M) | Avg. Volume Value (3M) |
|---|---|---|---|
| $12.61M | $7.85M | $5.63M | |
| $311.68M | $335.58M | $814.28M |
KPTI vs. RGTI - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | |
|---|---|---|---|---|---|---|
KPTI Karyopharm Therapeutics Inc. | -73.91% | -27.45% | -21.82% | -74.56% | -47.12% | -32.95% |
RGTI Rigetti Computing Inc | -32.51% | 45.15% | 1,449.40% | 35.07% | -92.91% | 3.94% |
Correlation
The correlation between KPTI and RGTI is 0.08, meaning there was essentially no consistent relationship between their historical price movements. Each responded to its own set of market drivers.
| Correlation | |
|---|---|
Correlation (1Y) Focuses on recent behavior, but can change the most. | 0.08 |
Correlation (3Y) Balances recent behavior with more history. | 0.16 |
Correlation (5Y) Shows whether the relationship held over a longer period. | 0.17 |
Correlation (All Time) Calculated using the full available price history since Apr 22, 2021 | 0.17 |
Fundamentals
KPTI:
$43.51M
RGTI:
$4.97B
KPTI:
-$11.39
RGTI:
-$0.70
KPTI:
0.22
RGTI:
482.72
KPTI:
$151.12M
RGTI:
$10.02M
KPTI:
$145.13M
RGTI:
$3.00M
KPTI:
-$93.05M
RGTI:
-$263.06M
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Return for Risk
KPTI vs. RGTI — Risk / Return Rank
KPTI
RGTI
KPTI vs. RGTI - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and Rigetti Computing Inc (RGTI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| KPTI | RGTI | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -0.45 | ||
| Sortino ratioReturn per unit of downside risk | -0.56 | ||
| Omega ratioGain probability vs. loss probability | 1.05 | 1.10 | -0.04 |
| Calmar ratioReturn relative to maximum drawdown | -0.61 | 0.04 | -0.65 |
| Martin ratioReturn relative to average drawdown | -2.42 | 0.06 | -2.48 |
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Drawdowns
KPTI vs. RGTI - Drawdown Comparison
The maximum KPTI drawdown since its inception was -99.73%, roughly equal to the maximum RGTI drawdown of -96.89%. Use the drawdown chart below to compare losses from any high point for KPTI and RGTI.
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Drawdown Indicators
| KPTI | RGTI | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.73% | -96.89% | -2.84% |
Max Drawdown (1Y)Largest decline over 1 year | -82.01% | -77.10% | -4.91% |
Max Drawdown (3Y)Largest decline over 3 years | -92.73% | -77.10% | -15.63% |
Max Drawdown (5Y)Largest decline over 5 years | -99.11% | -96.89% | -2.22% |
Max Drawdown (10Y)Largest decline over 10 years | -99.54% | — | — |
Current DrawdownCurrent decline from peak | -99.73% | -73.46% | -26.27% |
Average DrawdownAverage peak-to-trough decline | -75.59% | -59.10% | -16.49% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 20.49% | 55.89% | -35.40% |
Volatility
KPTI vs. RGTI - Volatility Comparison
Karyopharm Therapeutics Inc. (KPTI) has a higher volatility of 131.26% compared to Rigetti Computing Inc (RGTI) at 27.13%. This indicates that KPTI's price experiences larger fluctuations and is considered to be riskier than RGTI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| KPTI | RGTI | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 131.26% | 27.13% | +104.13% |
Volatility (6M)Calculated over the trailing 6-month period | 144.90% | 72.27% | +72.63% |
Volatility (1Y)Calculated over the trailing 1-year period | 117.57% | 106.53% | +11.04% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 101.03% | 129.86% | -28.83% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 89.78% | 126.39% | -36.61% |
Dividends
KPTI vs. RGTI - Dividend Comparison
Neither KPTI nor RGTI has paid dividends to shareholders.
Financials
KPTI vs. RGTI - Financials Comparison
This section allows you to compare key financial metrics between Karyopharm Therapeutics Inc. and Rigetti Computing Inc. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
KPTI and RGTI have a correlation of 0.08, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
KPTI has higher volatility (131.26%) compared to RGTI (27.13%). In terms of maximum drawdown, KPTI dropped -99.73% vs RGTI's -96.89%.
RGTI currently has the higher Sharpe Ratio (0.03 vs -0.42), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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