KPTI vs. OPEN
KPTI (Karyopharm Therapeutics Inc.) and OPEN (Opendoor Technologies Inc.) are both stocks. KPTI operates in Biotechnology (Healthcare), while OPEN operates in Real Estate - Services (Real Estate). Over the past 5 years, KPTI returned -41.77%/yr vs -21.02%/yr for OPEN. At a 0.29 correlation, their price movements are largely independent.
Performance
KPTI vs. OPEN - Performance Comparison
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Returns By Period
In the year-to-date period, KPTI achieves a 22.28% return, which is significantly higher than OPEN's -16.47% return.
KPTI
- 1D
- -2.49%
- 1M
- -3.23%
- YTD
- 22.28%
- 6M
- 64.84%
- 1Y
- 111.76%
- 3Y*
- -35.73%
- 5Y*
- -41.77%
- 10Y*
- -23.93%
OPEN
- 1D
- -9.98%
- 1M
- -5.07%
- YTD
- -16.47%
- 6M
- -29.83%
- 1Y
- 751.93%
- 3Y*
- 26.60%
- 5Y*
- -21.02%
- 10Y*
- —
KPTI vs. OPEN - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | |
|---|---|---|---|---|---|---|---|
KPTI Karyopharm Therapeutics Inc. | 22.28% | -27.45% | -21.82% | -74.56% | -47.12% | -58.46% | -16.91% |
OPEN Opendoor Technologies Inc. | -16.47% | 276.52% | -64.29% | 286.21% | -92.06% | -35.72% | 110.39% |
Correlation
The correlation between KPTI and OPEN is 0.08, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.08 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.24 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.30 |
Correlation (All Time) Calculated using the full available price history since Jun 19, 2020 | 0.29 |
Over the past year, the correlation between KPTI and OPEN has dropped to 0.08 - well below their long-term average of 0.29, suggesting their price drivers have been diverging.
Fundamentals
KPTI:
$222.44M
OPEN:
$4.67B
KPTI:
-$13.00
OPEN:
-$1.74
KPTI:
0.89
OPEN:
0.99
KPTI:
$151.12M
OPEN:
$3.94B
KPTI:
$145.13M
OPEN:
$312.00M
KPTI:
-$93.05M
OPEN:
-$1.25B
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Return for Risk
KPTI vs. OPEN — Risk / Return Rank
KPTI
OPEN
KPTI vs. OPEN - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Karyopharm Therapeutics Inc. (KPTI) and Opendoor Technologies Inc. (OPEN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| KPTI | OPEN | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 1.20 | 4.73 | -3.54 |
Sortino ratioReturn per unit of downside risk | 2.18 | 4.44 | -2.26 |
Omega ratioGain probability vs. loss probability | 1.25 | 1.52 | -0.27 |
Calmar ratioReturn relative to maximum drawdown | 2.32 | 13.10 | -10.78 |
Martin ratioReturn relative to average drawdown | 5.76 | 20.51 | -14.76 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| KPTI | OPEN | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 1.20 | 4.73 | -3.54 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | -0.44 | -0.19 | -0.26 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | -0.28 | — | — |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.26 | -0.11 | -0.15 |
Drawdowns
KPTI vs. OPEN - Drawdown Comparison
The maximum KPTI drawdown since its inception was -99.50%, roughly equal to the maximum OPEN drawdown of -98.57%. Use the drawdown chart below to compare losses from any high point for KPTI and OPEN.
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Drawdown Indicators
| KPTI | OPEN | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.50% | -98.57% | -0.93% |
Max Drawdown (1Y)Largest decline over 1 year | -48.36% | -57.96% | +9.60% |
Max Drawdown (3Y)Largest decline over 3 years | -90.08% | -90.28% | +0.20% |
Max Drawdown (5Y)Largest decline over 5 years | -98.36% | -97.93% | -0.43% |
Max Drawdown (10Y)Largest decline over 10 years | -99.15% | — | — |
Current DrawdownCurrent decline from peak | -98.73% | -85.97% | -12.76% |
Average DrawdownAverage peak-to-trough decline | -75.26% | -74.57% | -0.69% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 19.49% | 36.94% | -17.45% |
Volatility
KPTI vs. OPEN - Volatility Comparison
Karyopharm Therapeutics Inc. (KPTI) has a higher volatility of 24.41% compared to Opendoor Technologies Inc. (OPEN) at 19.07%. This indicates that KPTI's price experiences larger fluctuations and is considered to be riskier than OPEN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| KPTI | OPEN | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 24.41% | 19.07% | +5.34% |
Volatility (6M)Calculated over the trailing 6-month period | 62.85% | 52.34% | +10.51% |
Volatility (1Y)Calculated over the trailing 1-year period | 94.09% | 160.45% | -66.36% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 94.91% | 113.43% | -18.52% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 86.48% | 110.47% | -23.99% |
Dividends
KPTI vs. OPEN - Dividend Comparison
Neither KPTI nor OPEN has paid dividends to shareholders.
Financials
KPTI vs. OPEN - Financials Comparison
This section allows you to compare key financial metrics between Karyopharm Therapeutics Inc. and Opendoor Technologies Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
KPTI vs. OPEN - Profitability Comparison
KPTI - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported a gross profit of 33.72M and revenue of 35.07M. Therefore, the gross margin over that period was 96.2%.
OPEN - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Opendoor Technologies Inc. reported a gross profit of 72.00M and revenue of 720.00M. Therefore, the gross margin over that period was 10.0%.
KPTI - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported an operating income of -26.76M and revenue of 35.07M, resulting in an operating margin of -76.3%.
OPEN - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Opendoor Technologies Inc. reported an operating income of -159.00M and revenue of 720.00M, resulting in an operating margin of -22.1%.
KPTI - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Karyopharm Therapeutics Inc. reported a net income of -22.39M and revenue of 35.07M, resulting in a net margin of -63.9%.
OPEN - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Opendoor Technologies Inc. reported a net income of -173.00M and revenue of 720.00M, resulting in a net margin of -24.0%.
Frequently Asked Questions
KPTI and OPEN have a correlation of 0.08, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
KPTI has higher volatility (24.41%) compared to OPEN (19.07%). In terms of maximum drawdown, KPTI dropped -99.50% vs OPEN's -98.57%.
OPEN currently has the higher Sharpe Ratio (4.73 vs 1.20), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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