JANRX vs. JFNAX

Last updated Jun 23, 2026

JANRX (Janus Henderson Global Select Fund) and JFNAX (Janus Henderson Global Life Sciences Fund Class A) are both mutual funds - JANRX is a Global Equities fund managed by Janus Henderson, while JFNAX is a Health & Biotech Equities fund managed by Janus Henderson. Over the past 10 years, JANRX returned 13.67%/yr vs 11.10%/yr for JFNAX. A 0.70 correlation means they provide meaningful diversification when combined. JANRX charges 0.82%/yr vs 0.98%/yr for JFNAX.

Performance

JANRX vs. JFNAX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Janus Henderson Global Select Fund (JANRX) and Janus Henderson Global Life Sciences Fund Class A (JFNAX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JANRX achieves a 10.54% return, which is significantly higher than JFNAX's 0.49% return. Over the past 10 years, JANRX has outperformed JFNAX with an annualized return of 13.67%, while JFNAX has yielded a comparatively lower 11.10% annualized return.

JANRX

• 1D: 1.33%
• 1M: 2.05%
• YTD: 10.54%
• 6M: 10.94%
• 1Y: 22.33%
• 3Y*: 18.72%
• 5Y*: 11.40%
• 10Y*: 13.67%

JFNAX

• 1D: -0.39%
• 1M: 0.71%
• YTD: 0.49%
• 6M: -0.05%
• 1Y: 30.95%
• 3Y*: 10.06%
• 5Y*: 6.99%
• 10Y*: 11.10%

*Multi-year figures are annualized to reflect compound growth (CAGR)

JANRX vs. JFNAX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JANRX Janus Henderson Global Select Fund	10.54%	19.49%	17.21%	17.41%	-9.94%	15.96%	16.14%	27.43%	-9.80%	31.08%
JFNAX Janus Henderson Global Life Sciences Fund Class A	0.49%	24.61%	3.41%	7.35%	-2.86%	6.59%	25.42%	28.98%	4.00%	22.35%

Correlation

The correlation between JANRX and JFNAX is 0.46, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.46
Correlation (3Y) Calculated over the trailing 3-year period	0.56
Correlation (5Y) Calculated over the trailing 5-year period	0.64
Correlation (10Y) Calculated over the trailing 10-year period	0.66
Correlation (All Time) Calculated using the full available price history since Jul 6, 2009	0.70

Over the past year, the correlation between JANRX and JFNAX has dropped to 0.46 - well below their long-term average of 0.70, suggesting their price drivers have been diverging.

Return for Risk

JANRX vs. JFNAX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JANRX

JANRX Risk / Return Rank: 43
JANRX Sharpe Ratio Rank: 42
JANRX Sortino Ratio Rank: 40
JANRX Omega Ratio Rank: 42
JANRX Calmar Ratio Rank: 39
JANRX Martin Ratio Rank: 51

JFNAX

JFNAX Risk / Return Rank: 58
JFNAX Sharpe Ratio Rank: 56
JFNAX Sortino Ratio Rank: 60
JFNAX Omega Ratio Rank: 50
JFNAX Calmar Ratio Rank: 73
JFNAX Martin Ratio Rank: 52

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JANRX vs. JFNAX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Select Fund (JANRX) and Janus Henderson Global Life Sciences Fund Class A (JFNAX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	JANRX	JFNAX	Difference
Sharpe ratio: Return per unit of total volatility	1.74	2.02	-0.28
Sortino ratio: Return per unit of downside risk	2.46	2.96	-0.50
Omega ratio: Gain probability vs. loss probability	1.32	1.35	-0.03
Calmar ratio: Return relative to maximum drawdown	2.26	3.15	-0.89
Martin ratio: Return relative to average drawdown	9.85	10.01	-0.16

JANRX vs. JFNAX - Sharpe Ratio Comparison

The current JANRX Sharpe Ratio is 1.74, which is comparable to the JFNAX Sharpe Ratio of 2.02. The chart below compares the historical Sharpe Ratios of JANRX and JFNAX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

JANRX vs. JFNAX - Drawdown Comparison

The maximum JANRX drawdown since its inception was -63.94%, which is greater than JFNAX's maximum drawdown of -31.07%. Use the drawdown chart below to compare losses from any high point for JANRX and JFNAX.

Drawdown Indicators

	JANRX	JFNAX	Difference
Max Drawdown Largest peak-to-trough decline	-63.94%	-31.07%	-32.87%
Max Drawdown (1Y) Largest decline over 1 year	-9.67%	-9.71%	+0.04%
Max Drawdown (3Y) Largest decline over 3 years	-19.56%	-21.28%	+1.72%
Max Drawdown (5Y) Largest decline over 5 years	-23.48%	-22.29%	-1.19%
Max Drawdown (10Y) Largest decline over 10 years	-39.17%	-27.39%	-11.78%
Current Drawdown Current decline from peak	0.00%	-2.52%	+2.52%
Average Drawdown Average peak-to-trough decline	-17.76%	-6.28%	-11.48%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.22%	3.06%	-0.84%

Volatility

JANRX vs. JFNAX - Volatility Comparison

Janus Henderson Global Select Fund (JANRX) has a higher volatility of 5.67% compared to Janus Henderson Global Life Sciences Fund Class A (JFNAX) at 5.37%. This indicates that JANRX's price experiences larger fluctuations and is considered to be riskier than JFNAX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JANRX	JFNAX	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.67%	5.37%	+0.30%
Volatility (6M) Calculated over the trailing 6-month period	10.79%	11.25%	-0.46%
Volatility (1Y) Calculated over the trailing 1-year period	12.56%	15.14%	-2.58%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	16.32%	15.91%	+0.41%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	18.02%	17.39%	+0.63%

JANRX vs. JFNAX - Expense Ratio Comparison

JANRX has a 0.82% expense ratio, which is lower than JFNAX's 0.98% expense ratio.

Dividends

JANRX vs. JFNAX - Dividend Comparison

JANRX's dividend yield for the trailing twelve months is around 9.68%, more than JFNAX's 4.53% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
JANRX Janus Henderson Global Select Fund	9.68%	10.71%	10.44%	8.62%	2.81%	13.04%	5.11%	4.37%	17.07%	0.86%	1.14%	1.08%
JFNAX Janus Henderson Global Life Sciences Fund Class A	4.53%	4.56%	5.74%	4.28%	0.08%	9.90%	7.82%	6.18%	13.55%	1.03%	0.97%	8.93%

Frequently Asked Questions

Can I hold both JANRX and JFNAX in my portfolio?

JANRX and JFNAX have a correlation of 0.46, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JANRX or JFNAX?

JANRX has higher volatility (5.67%) compared to JFNAX (5.37%). In terms of maximum drawdown, JANRX dropped -63.94% vs JFNAX's -31.07%.

Which has better risk-adjusted returns?

JFNAX currently has the higher Sharpe Ratio (2.02 vs 1.74), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.