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Janus Henderson Global Life Sciences Fund Class A (JFNAX) Sortino Ratio: 1.81

JFNAX's Sortino Ratio of 1.81 indicates that for each unit of downside volatility, it generates 1.81 units of excess return. The ratio is calculated using historical daily returns over the past 12 months (as of Apr 3, 2026).

Unlike other measures, Sortino only focuses on downside volatility (losses), making it particularly useful for investors more concerned about protecting against drawdowns than overall price swings.

JFNAX Sortino Ratio Rank


JFNAX Sortino Ratio Rank: 60.560
Above Average

JFNAX ranks above 60.5% of all investments in our database based on Sortino Ratio over the past 12 months, indicating above-average returns relative to downside risk taken. Securities are ranked from 0 (worst) to 100 (best).

What moves the rank

  • Strong returns with minimal downside volatility → Higher rank
  • Severe or frequent drawdowns → Lower rank
  • Upside volatility → No impact (Sortino doesn't penalize upside swings)

What you can do with this information

  • Above-average downside protection with room for improvement
  • Compare against category peers to gauge relative positioning
  • Monitor for movement toward top tier or decline toward median
  • Consider pairing with top-tier holdings to improve portfolio risk profile

JFNAX Sortino Ratio Market Positioning

The chart shows JFNAX's Sortino Ratio relative to all mutual funds on our platform, with color zones indicating percentile rankings. Higher ratios indicate better downside-adjusted returns.


  • Red zone (bottom 25%): 1.15 or lower
  • Yellow zone (middle 50%): 1.15 to 2.11
  • Green zone (top 25%): 2.11 or higher
  • Top 1%: 7.12+
  • Median: 1.62 — half of all investments score higher

How it compares to other similar mutual funds

The table compares Janus Henderson Global Life Sciences Fund Class A's Sortino Ratio with other mutual funds in the Health & Biotech Equities category across multiple time periods, showing how JFNAX's risk-adjusted performance compares to similar funds.

Data shows 1-, 5-, and 10-year periods, plus each fund's all-time average, as of Apr 3, 2026.


SymbolName1Y Sortino Ratio5Y Sortino Ratio10Y Sortino RatioAll Time Sortino Ratio
FBDIXFranklin Biotechnology Discovery Fund3.47
ETIHXEventide Healthcare & Life Sciences Fund3.37
FIJYXFidelity Advisor Biotechnology Fund Class Z2.83
FBTIXFidelity Advisor Biotechnology Fund I Class2.82
FBTAXFidelity Advisor Biotechnology Fund Class A2.80
FBTTXFidelity Advisor Biotechnology Fund Class M2.79
FBTCXFidelity Advisor Biotechnology Fund Class C2.76
FBIOXFidelity Select Biotechnology Portfolio2.55
RYOIXRydex Biotechnology Fund2.36
PRHSXT. Rowe Price Health Sciences Fund2.16
JFNAXJanus Henderson Global Life Sciences Fund Class A1.81

S&P 500 Index

How to choose period

Historical Sortino Ratio

The chart shows JFNAX's rolling Sortino ratio over time compared to your chosen benchmark. Rising trends indicate improving returns relative to downside risk, while declining trends may signal deteriorating risk-adjusted performance or increased volatility during market stress. Use multiple timeframes to distinguish short-term fluctuations from long-term patterns.

Identify market cycles by observing when JFNAX consistently outperforms (line above benchmark), underperforms (below benchmark), or aligns with the benchmark.


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Explore JFNAX risk-adjusted metrics in detail

Dive deeper into individual metrics with historical trends, benchmark comparisons, and performance across different time periods.