INSM vs. ILMN
INSM (Insmed Incorporated) and ILMN (Illumina, Inc.) are both stocks. Both are in the Healthcare sector — INSM in Biotechnology, ILMN in Diagnostics & Research. Over the past 10 years, INSM returned 24.16%/yr vs 1.90%/yr for ILMN. At a 0.24 correlation, their price movements are largely independent.
Performance
INSM vs. ILMN - Performance Comparison
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Returns By Period
In the year-to-date period, INSM achieves a -40.32% return, which is significantly lower than ILMN's 30.32% return. Over the past 10 years, INSM has outperformed ILMN with an annualized return of 24.16%, while ILMN has yielded a comparatively lower 1.90% annualized return.
INSM
- 1D
- 0.13%
- 1M
- -25.82%
- YTD
- -40.32%
- 6M
- -49.77%
- 1Y
- 42.12%
- 3Y*
- 74.52%
- 5Y*
- 32.61%
- 10Y*
- 24.16%
ILMN
- 1D
- 5.16%
- 1M
- 22.64%
- YTD
- 30.32%
- 6M
- 33.59%
- 1Y
- 108.88%
- 3Y*
- -5.36%
- 5Y*
- -15.92%
- 10Y*
- 1.90%
INSM vs. ILMN - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
INSM Insmed Incorporated | -40.32% | 152.09% | 122.78% | 55.11% | -26.65% | -18.17% | 39.41% | 82.01% | -57.92% | 135.68% |
ILMN Illumina, Inc. | 30.32% | -1.85% | -1.34% | -31.14% | -46.85% | 2.82% | 11.53% | 10.61% | 37.27% | 70.64% |
Correlation
The correlation between INSM and ILMN is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | 0.12 |
Correlation (3Y) Calculated over the trailing 3-year period | 0.21 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.30 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.34 |
Correlation (All Time) Calculated using the full available price history since Jul 31, 2000 | 0.24 |
The correlation between INSM and ILMN shifts across timeframes, from 0.12 (1 year) to 0.34 (10 years), reflecting how their relationship changes across market environments.
Fundamentals
INSM:
$22.38B
ILMN:
$26.32B
INSM:
-$5.71
ILMN:
$5.48
INSM:
26.29
ILMN:
6.06
INSM:
31.75
ILMN:
8.69
INSM:
$819.56M
ILMN:
$4.39B
INSM:
$668.55M
ILMN:
$2.93B
INSM:
-$1.14B
ILMN:
$1.39B
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Return for Risk
INSM vs. ILMN — Risk / Return Rank
INSM
ILMN
INSM vs. ILMN - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Insmed Incorporated (INSM) and Illumina, Inc. (ILMN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| INSM | ILMN | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.61 | ||
| Sortino ratioReturn per unit of downside risk | -1.87 | ||
| Omega ratioGain probability vs. loss probability | 1.22 | 1.39 | -0.18 |
| Calmar ratioReturn relative to maximum drawdown | 0.81 | 4.27 | -3.45 |
| Martin ratioReturn relative to average drawdown | 1.93 | 9.67 | -7.74 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| INSM | ILMN | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.73 | 2.33 | -1.61 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.45 | -0.35 | +0.80 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.31 | 0.05 | +0.26 |
Sharpe Ratio (All Time)Calculated using the full available price history | -0.02 | 0.16 | -0.18 |
Drawdowns
INSM vs. ILMN - Drawdown Comparison
The maximum INSM drawdown since its inception was -98.65%, roughly equal to the maximum ILMN drawdown of -96.14%. Use the drawdown chart below to compare losses from any high point for INSM and ILMN.
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Drawdown Indicators
| INSM | ILMN | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -98.65% | -96.14% | -2.51% |
Max Drawdown (1Y)Largest decline over 1 year | -52.06% | -25.66% | -26.40% |
Max Drawdown (3Y)Largest decline over 3 years | -52.06% | -65.68% | +13.62% |
Max Drawdown (5Y)Largest decline over 5 years | -52.06% | -86.23% | +34.17% |
Max Drawdown (10Y)Largest decline over 10 years | -64.84% | -86.23% | +21.39% |
Current DrawdownCurrent decline from peak | -50.87% | -66.52% | +15.65% |
Average DrawdownAverage peak-to-trough decline | -86.12% | -40.37% | -45.75% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 21.89% | 11.30% | +10.59% |
Volatility
INSM vs. ILMN - Volatility Comparison
Insmed Incorporated (INSM) has a higher volatility of 30.56% compared to Illumina, Inc. (ILMN) at 9.58%. This indicates that INSM's price experiences larger fluctuations and is considered to be riskier than ILMN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| INSM | ILMN | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 30.56% | 9.58% | +20.98% |
Volatility (6M)Calculated over the trailing 6-month period | 43.84% | 29.23% | +14.61% |
Volatility (1Y)Calculated over the trailing 1-year period | 58.25% | 46.92% | +11.33% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 72.66% | 45.66% | +27.00% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 78.47% | 42.17% | +36.30% |
Dividends
INSM vs. ILMN - Dividend Comparison
Neither INSM nor ILMN has paid dividends to shareholders.
Financials
INSM vs. ILMN - Financials Comparison
This section allows you to compare key financial metrics between Insmed Incorporated and Illumina, Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
INSM vs. ILMN - Profitability Comparison
INSM - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Insmed Incorporated reported a gross profit of 258.54M and revenue of 305.96M. Therefore, the gross margin over that period was 84.5%.
ILMN - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Jun 2026, Illumina, Inc. reported a gross profit of 721.00M and revenue of 1.09B. Therefore, the gross margin over that period was 66.1%.
INSM - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Insmed Incorporated reported an operating income of -198.20M and revenue of 305.96M, resulting in an operating margin of -64.8%.
ILMN - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Jun 2026, Illumina, Inc. reported an operating income of 209.00M and revenue of 1.09B, resulting in an operating margin of 19.2%.
INSM - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Insmed Incorporated reported a net income of -163.56M and revenue of 305.96M, resulting in a net margin of -53.5%.
ILMN - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Jun 2026, Illumina, Inc. reported a net income of 134.00M and revenue of 1.09B, resulting in a net margin of 12.3%.
Frequently Asked Questions
INSM and ILMN have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
INSM has higher volatility (30.56%) compared to ILMN (9.58%). In terms of maximum drawdown, INSM dropped -98.65% vs ILMN's -96.14%.
ILMN currently has the higher Sharpe Ratio (2.33 vs 0.73), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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