INSM vs. SRPT

Last updated Apr 2, 2026

Compare and contrast key facts about Insmed Incorporated (INSM) and Sarepta Therapeutics, Inc. (SRPT).

Performance

INSM vs. SRPT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Insmed Incorporated (INSM) and Sarepta Therapeutics, Inc. (SRPT). The values are adjusted to include any dividend payments, if applicable.

INSM vs. SRPT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
INSM Insmed Incorporated	-5.27%	152.09%	122.78%	55.11%	-26.65%	-18.17%	39.41%	82.01%	-57.92%	135.68%
SRPT Sarepta Therapeutics, Inc.	2.83%	-82.30%	26.09%	-25.58%	43.90%	-47.18%	32.12%	18.24%	96.14%	102.84%

Fundamentals

Market Cap INSM : $35.22B SRPT : $2.32B
EPS INSM : -$6.23 SRPT : -$8.11
PS Ratio INSM : 55.67 SRPT : 1.05
PB Ratio INSM : 47.66 SRPT : 2.03
Total Revenue (TTM) INSM : $606.42M SRPT : $2.20B
Gross Profit (TTM) INSM : $483.49M SRPT : -$1.05B
EBITDA (TTM) INSM : -$1.19B SRPT : -$778.95M

Returns By Period

In the year-to-date period, INSM achieves a -5.27% return, which is significantly lower than SRPT's 2.83% return. Over the past 10 years, INSM has outperformed SRPT with an annualized return of 29.27%, while SRPT has yielded a comparatively lower 1.03% annualized return.

INSM

• 1D: 0.82%
• 1M: 12.67%
• YTD: -5.27%
• 6M: 11.94%
• 1Y: 128.97%
• 3Y*: 113.04%
• 5Y*: 36.00%
• 10Y*: 29.27%

SRPT

• 1D: 1.70%
• 1M: 35.60%
• YTD: 2.83%
• 6M: 14.54%
• 1Y: -64.25%
• 3Y*: -45.65%
• 5Y*: -21.91%
• 10Y*: 1.03%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

INSM vs. SRPT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

INSM

INSM Risk / Return Rank: 90
INSM Sharpe Ratio Rank: 93
INSM Sortino Ratio Rank: 93
INSM Omega Ratio Rank: 93
INSM Calmar Ratio Rank: 86
INSM Martin Ratio Rank: 85

SRPT

SRPT Risk / Return Rank: 18
SRPT Sharpe Ratio Rank: 15
SRPT Sortino Ratio Rank: 20
SRPT Omega Ratio Rank: 18
SRPT Calmar Ratio Rank: 12
SRPT Martin Ratio Rank: 23

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

INSM vs. SRPT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Insmed Incorporated (INSM) and Sarepta Therapeutics, Inc. (SRPT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	INSM	SRPT	Difference
Sharpe ratio Return per unit of total volatility	2.46	-0.59	+3.04
Sortino ratio Return per unit of downside risk	3.31	-0.42	+3.72
Omega ratio Gain probability vs. loss probability	1.46	0.93	+0.53
Calmar ratio Return relative to maximum drawdown	3.25	-0.80	+4.06
Martin ratio Return relative to average drawdown	7.96	-1.03	+8.99
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

INSM vs. SRPT - Sharpe Ratio Comparison

The current INSM Sharpe Ratio is 2.46, which is higher than the SRPT Sharpe Ratio of -0.59. The chart below compares the historical Sharpe Ratios of INSM and SRPT, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	INSM	SRPT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.46	-0.59	+3.04
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.50	-0.32	+0.82
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.38	0.01	+0.36
Sharpe Ratio (All Time) Calculated using the full available price history	0.00	-0.02	+0.02

Correlation

The correlation between INSM and SRPT is 0.26, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

INSM vs. SRPT - Dividend Comparison

Neither INSM nor SRPT has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

INSM vs. SRPT - Drawdown Comparison

The maximum INSM drawdown since its inception was -98.65%, roughly equal to the maximum SRPT drawdown of -98.17%. Use the drawdown chart below to compare losses from any high point for INSM and SRPT.

Drawdown Indicators

	INSM	SRPT	Difference
Max Drawdown Largest peak-to-trough decline	-98.65%	-98.17%	-0.48%
Max Drawdown (1Y) Largest decline over 1 year	-35.67%	-81.26%	+45.59%
Max Drawdown (5Y) Largest decline over 5 years	-54.85%	-92.72%	+37.87%
Max Drawdown (10Y) Largest decline over 10 years	-64.84%	-93.33%	+28.49%
Current Drawdown Current decline from peak	-22.02%	-87.62%	+65.60%
Average Drawdown Average peak-to-trough decline	-86.43%	-68.02%	-18.41%
Ulcer Index Depth and duration of drawdowns from previous peaks	14.59%	63.52%	-48.93%

Volatility

INSM vs. SRPT - Volatility Comparison

The current volatility for Insmed Incorporated (INSM) is 15.96%, while Sarepta Therapeutics, Inc. (SRPT) has a volatility of 34.93%. This indicates that INSM experiences smaller price fluctuations and is considered to be less risky than SRPT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	INSM	SRPT	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.96%	34.93%	-18.97%
Volatility (6M) Calculated over the trailing 6-month period	35.48%	70.71%	-35.23%
Volatility (1Y) Calculated over the trailing 1-year period	53.17%	109.93%	-56.76%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	72.38%	69.76%	+2.62%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	78.15%	75.46%	+2.69%

Financials