ILMN vs. CRL

Last updated Apr 1, 2026

Compare and contrast key facts about Illumina, Inc. (ILMN) and Charles River Laboratories International, Inc. (CRL).

Performance

ILMN vs. CRL - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Illumina, Inc. (ILMN) and Charles River Laboratories International, Inc. (CRL). The values are adjusted to include any dividend payments, if applicable.

ILMN vs. CRL - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ILMN Illumina, Inc.	-6.02%	-1.85%	-1.34%	-31.14%	-46.85%	2.82%	11.53%	10.61%	37.27%	70.64%
CRL Charles River Laboratories International, Inc.	-13.53%	8.06%	-21.91%	8.49%	-42.17%	50.80%	63.56%	34.97%	3.41%	43.65%

Fundamentals

Market Cap ILMN : $18.98B CRL : $8.49B
EPS ILMN : $5.44 CRL : -$2.93
PS Ratio ILMN : 4.44 CRL : 2.12
PB Ratio ILMN : 6.16 CRL : 2.68
Total Revenue (TTM) ILMN : $4.34B CRL : $4.02B
Gross Profit (TTM) ILMN : $2.89B CRL : $1.01B
EBITDA (TTM) ILMN : $1.46B CRL : $319.45M

Returns By Period

In the year-to-date period, ILMN achieves a -6.02% return, which is significantly higher than CRL's -13.53% return. Over the past 10 years, ILMN has underperformed CRL with an annualized return of -2.71%, while CRL has yielded a comparatively higher 8.32% annualized return.

ILMN

• 1D: 2.03%
• 1M: -8.33%
• YTD: -6.02%
• 6M: 29.79%
• 1Y: 55.36%
• 3Y*: -18.32%
• 5Y*: -19.93%
• 10Y*: -2.71%

CRL

• 1D: 8.00%
• 1M: -3.36%
• YTD: -13.53%
• 6M: 10.25%
• 1Y: 14.60%
• 3Y*: -5.10%
• 5Y*: -10.13%
• 10Y*: 8.32%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

ILMN vs. CRL — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ILMN

ILMN Risk / Return Rank: 77
ILMN Sharpe Ratio Rank: 78
ILMN Sortino Ratio Rank: 78
ILMN Omega Ratio Rank: 73
ILMN Calmar Ratio Rank: 79
ILMN Martin Ratio Rank: 78

CRL

CRL Risk / Return Rank: 51
CRL Sharpe Ratio Rank: 51
CRL Sortino Ratio Rank: 49
CRL Omega Ratio Rank: 52
CRL Calmar Ratio Rank: 50
CRL Martin Ratio Rank: 51

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ILMN vs. CRL - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Illumina, Inc. (ILMN) and Charles River Laboratories International, Inc. (CRL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ILMN	CRL	Difference
Sharpe ratio Return per unit of total volatility	1.14	0.26	+0.88
Sortino ratio Return per unit of downside risk	1.94	0.73	+1.22
Omega ratio Gain probability vs. loss probability	1.23	1.12	+0.12
Calmar ratio Return relative to maximum drawdown	2.11	0.32	+1.78
Martin ratio Return relative to average drawdown	5.22	0.74	+4.48
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ILMN vs. CRL - Sharpe Ratio Comparison

The current ILMN Sharpe Ratio is 1.14, which is higher than the CRL Sharpe Ratio of 0.26. The chart below compares the historical Sharpe Ratios of ILMN and CRL, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	ILMN	CRL	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.14	0.26	+0.88
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.44	-0.24	-0.20
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.06	0.22	-0.29
Sharpe Ratio (All Time) Calculated using the full available price history	0.13	0.23	-0.10

Correlation

The correlation between ILMN and CRL is 0.39, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

ILMN vs. CRL - Dividend Comparison

Neither ILMN nor CRL has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

ILMN vs. CRL - Drawdown Comparison

The maximum ILMN drawdown since its inception was -96.14%, which is greater than CRL's maximum drawdown of -78.23%. Use the drawdown chart below to compare losses from any high point for ILMN and CRL.

Drawdown Indicators

	ILMN	CRL	Difference
Max Drawdown Largest peak-to-trough decline	-96.14%	-78.23%	-17.91%
Max Drawdown (1Y) Largest decline over 1 year	-25.66%	-33.18%	+7.52%
Max Drawdown (5Y) Largest decline over 5 years	-86.23%	-78.23%	-8.00%
Max Drawdown (10Y) Largest decline over 10 years	-86.23%	-78.23%	-8.00%
Current Drawdown Current decline from peak	-75.86%	-62.36%	-13.50%
Average Drawdown Average peak-to-trough decline	-40.15%	-25.47%	-14.68%
Ulcer Index Depth and duration of drawdowns from previous peaks	10.36%	14.67%	-4.31%

Volatility

ILMN vs. CRL - Volatility Comparison

The current volatility for Illumina, Inc. (ILMN) is 10.88%, while Charles River Laboratories International, Inc. (CRL) has a volatility of 17.13%. This indicates that ILMN experiences smaller price fluctuations and is considered to be less risky than CRL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ILMN	CRL	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.88%	17.13%	-6.25%
Volatility (6M) Calculated over the trailing 6-month period	36.52%	32.68%	+3.84%
Volatility (1Y) Calculated over the trailing 1-year period	49.01%	56.65%	-7.64%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	45.30%	41.85%	+3.45%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	42.62%	37.20%	+5.42%

Financials

ILMN vs. CRL - Profitability Comparison

The chart below illustrates the profitability comparison between Illumina, Inc. and Charles River Laboratories International, Inc. over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

ILMN - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Illumina, Inc. reported a gross profit of 777.00M and revenue of 1.16B. Therefore, the gross margin over that period was 67.0%.

CRL - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Charles River Laboratories International, Inc. reported a gross profit of 0.00 and revenue of 994.23M. Therefore, the gross margin over that period was 0.0%.

ILMN - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Illumina, Inc. reported an operating income of 256.00M and revenue of 1.16B, resulting in an operating margin of 22.1%.

CRL - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Charles River Laboratories International, Inc. reported an operating income of -283.44M and revenue of 994.23M, resulting in an operating margin of -28.5%.

ILMN - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Illumina, Inc. reported a net income of 334.00M and revenue of 1.16B, resulting in a net margin of 28.8%.

CRL - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Charles River Laboratories International, Inc. reported a net income of -276.56M and revenue of 994.23M, resulting in a net margin of -27.8%.