IBRN vs. XLVI
IBRN (iShares Neuroscience and Healthcare ETF) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - IBRN is a Health & Biotech Equities fund tracking the NYSE FactSet Global Neuro Biopharma and MedTech Index, while XLVI is a Derivative Income fund actively managed by State Street. IBRN is passively managed, while XLVI is actively managed. At a 0.44 correlation, their price movements are largely independent. IBRN charges 0.47%/yr vs 0.35%/yr for XLVI.
Performance
IBRN vs. XLVI - Performance Comparison
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Returns By Period
In the year-to-date period, IBRN achieves a 18.23% return, which is significantly higher than XLVI's 6.03% return.
IBRN
- 1D
- -2.16%
- 1M
- 9.69%
- 6M
- 19.74%
- YTD
- 18.23%
- 1Y
- 69.86%
- 3Y*
- 16.48%
- 5Y*
- —
- 10Y*
- —
XLVI
- 1D
- 0.01%
- 1M
- 3.67%
- 6M
- 4.16%
- YTD
- 6.03%
- 1Y
- —
- 3Y*
- —
- 5Y*
- —
- 10Y*
- —
IBRN vs. XLVI - Yearly Performance Comparison
| 2026 (YTD) | 2025 | |
|---|---|---|
IBRN iShares Neuroscience and Healthcare ETF | 18.23% | 41.73% |
XLVI State Street Health Care Select Sector SPDR Premium Income ETF | 6.03% | 12.41% |
Correlation
The correlation between IBRN and XLVI is 0.44, which is low. Their price movements are largely independent, making them effective diversification partners.
| Correlation | |
|---|---|
Correlation (All Time) Calculated using the full available price history since Jul 30, 2025 | 0.44 |
IBRN vs. XLVI - Sectors Allocation Comparison
Sectors
IBRN
XLVI
Healthcare
Basic Materials
-
-
Communication Services
-
-
Consumer Cyclical
-
-
Consumer Defensive
-
-
Energy
-
-
Financial Services
-
Industrials
-
-
Real Estate
-
-
Technology
-
-
Utilities
-
-
Healthcare
IBRN
XLVI
Basic Materials
IBRN
-
XLVI
-
Communication Services
IBRN
-
XLVI
-
Consumer Cyclical
IBRN
-
XLVI
-
Consumer Defensive
IBRN
-
XLVI
-
Energy
IBRN
-
XLVI
-
Financial Services
IBRN
-
XLVI
Industrials
IBRN
-
XLVI
-
Real Estate
IBRN
-
XLVI
-
Technology
IBRN
-
XLVI
-
Utilities
IBRN
-
XLVI
-
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Return for Risk
IBRN vs. XLVI — Risk / Return Rank
IBRN
XLVI
Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.
IBRN vs. XLVI - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for iShares Neuroscience and Healthcare ETF (IBRN) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| IBRN | XLVI | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | — | — | |
| Sortino ratioReturn per unit of downside risk | — | — | |
| Omega ratioGain probability vs. loss probability | 1.43 | — | — |
| Calmar ratioReturn relative to maximum drawdown | 7.98 | — | — |
| Martin ratioReturn relative to average drawdown | 22.47 | — | — |
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Drawdowns
IBRN vs. XLVI - Drawdown Comparison
The maximum IBRN drawdown since its inception was -35.38%, which is greater than XLVI's maximum drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for IBRN and XLVI.
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Drawdown Indicators
| IBRN | XLVI | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -35.38% | -8.14% | -27.24% |
Max Drawdown (1Y)Largest decline over 1 year | -8.80% | — | — |
Max Drawdown (3Y)Largest decline over 3 years | -35.38% | — | — |
Current DrawdownCurrent decline from peak | -5.16% | -0.02% | -5.14% |
Average DrawdownAverage peak-to-trough decline | -9.63% | -1.84% | -7.79% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 3.12% | — | — |
Volatility
IBRN vs. XLVI - Volatility Comparison
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Volatility by Period
| IBRN | XLVI | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 6.66% | — | — |
Volatility (6M)Calculated over the trailing 6-month period | 19.29% | — | — |
Volatility (1Y)Calculated over the trailing 1-year period | 25.51% | 10.87% | +14.64% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 25.34% | 10.87% | +14.47% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 25.34% | 10.87% | +14.47% |
IBRN vs. XLVI - Expense Ratio Comparison
IBRN has a 0.47% expense ratio, which is higher than XLVI's 0.35% expense ratio.
Dividends
IBRN vs. XLVI - Dividend Comparison
IBRN's dividend yield for the trailing twelve months is around 0.84%, less than XLVI's 11.92% yield.
| Position | TTM | 2025 | 2024 | 2023 |
|---|---|---|---|---|
IBRN iShares Neuroscience and Healthcare ETF | 0.84% | 0.99% | 0.40% | 0.06% |
XLVI State Street Health Care Select Sector SPDR Premium Income ETF | 11.92% | 5.73% | 0.00% | 0.00% |
Frequently Asked Questions
IBRN and XLVI have a correlation of 0.44, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.
XLVI is cheaper with a 0.35% expense ratio, compared with 0.47% for IBRN.
XLVI has the higher dividend yield at 11.92%, compared with 0.84% for IBRN.
IBRN is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: iShares and State Street. Their fees differ too: 0.47% for IBRN and 0.35% for XLVI.
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