GPCR vs. PLRZ

Last updated Jun 4, 2026

GPCR (Structure Therapeutics Inc. American Depositary Shares) and PLRZ (Polyrizon Ltd) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past year, GPCR returned 70.69% vs 176.95% for PLRZ. At a 0.05 correlation, their price movements are largely independent.

Performance

GPCR vs. PLRZ - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Structure Therapeutics Inc. American Depositary Shares (GPCR) and Polyrizon Ltd (PLRZ). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GPCR achieves a -46.08% return, which is significantly lower than PLRZ's 58.54% return.

GPCR

• 1D: 0.83%
• 1M: -12.87%
• YTD: -46.08%
• 6M: 18.60%
• 1Y: 70.69%
• 3Y*: 5.51%
• 5Y*: —
• 10Y*: —

PLRZ

• 1D: -4.47%
• 1M: -12.60%
• YTD: 58.54%
• 6M: 89.84%
• 1Y: 176.95%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

GPCR vs. PLRZ - Yearly Performance Comparison

	2026 (YTD)	2025	2024
GPCR Structure Therapeutics Inc. American Depositary Shares	-46.08%	156.45%	-30.53%
PLRZ Polyrizon Ltd	58.54%	-99.74%	40.00%

Correlation

The correlation between GPCR and PLRZ is 0.06, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.06
Correlation (All Time) Calculated using the full available price history since Oct 30, 2024	0.05

Fundamentals

Market Cap GPCR : $2.72B PLRZ : $21.65M
EPS GPCR : -$2.75 PLRZ : -$2.70
PB Ratio GPCR : 1.88 PLRZ : 1.03
Total Revenue (TTM) GPCR : $0.00 PLRZ : $0.00
Gross Profit (TTM) GPCR : $0.00 PLRZ : -$459.00K
EBITDA (TTM) GPCR : -$191.27M PLRZ : -$4.45M

Return for Risk

GPCR vs. PLRZ — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GPCR

GPCR Risk / Return Rank: 70
GPCR Sharpe Ratio Rank: 61
GPCR Sortino Ratio Rank: 84
GPCR Omega Ratio Rank: 78
GPCR Calmar Ratio Rank: 64
GPCR Martin Ratio Rank: 63

PLRZ

PLRZ Risk / Return Rank: 81
PLRZ Sharpe Ratio Rank: 67
PLRZ Sortino Ratio Rank: 93
PLRZ Omega Ratio Rank: 89
PLRZ Calmar Ratio Rank: 78
PLRZ Martin Ratio Rank: 77

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GPCR vs. PLRZ - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Structure Therapeutics Inc. American Depositary Shares (GPCR) and Polyrizon Ltd (PLRZ). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	GPCR	PLRZ	Difference
Sharpe ratio: Return per unit of total volatility	0.60	0.80	-0.20
Sortino ratio: Return per unit of downside risk	2.63	3.64	-1.01
Omega ratio: Gain probability vs. loss probability	1.29	1.41	-0.13
Calmar ratio: Return relative to maximum drawdown	1.15	2.47	-1.31
Martin ratio: Return relative to average drawdown	2.53	5.47	-2.93
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

GPCR vs. PLRZ - Sharpe Ratio Comparison

The current GPCR Sharpe Ratio is 0.60, which is comparable to the PLRZ Sharpe Ratio of 0.80. The chart below compares the historical Sharpe Ratios of GPCR and PLRZ, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	GPCR	PLRZ	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.60	0.80	-0.20
Sharpe Ratio (All Time) Calculated using the full available price history	0.12	-0.26	+0.37

Drawdowns

GPCR vs. PLRZ - Drawdown Comparison

The maximum GPCR drawdown since its inception was -80.96%, smaller than the maximum PLRZ drawdown of -99.94%. Use the drawdown chart below to compare losses from any high point for GPCR and PLRZ.

Drawdown Indicators

	GPCR	PLRZ	Difference
Max Drawdown Largest peak-to-trough decline	-80.96%	-99.94%	+18.98%
Max Drawdown (1Y) Largest decline over 1 year	-61.74%	-72.23%	+10.49%
Max Drawdown (3Y) Largest decline over 3 years	-80.96%	—	—
Current Drawdown Current decline from peak	-60.02%	-99.73%	+39.71%
Average Drawdown Average peak-to-trough decline	-41.99%	-87.33%	+45.34%
Ulcer Index Depth and duration of drawdowns from previous peaks	27.98%	32.50%	-4.52%

Volatility

GPCR vs. PLRZ - Volatility Comparison

The current volatility for Structure Therapeutics Inc. American Depositary Shares (GPCR) is 13.49%, while Polyrizon Ltd (PLRZ) has a volatility of 33.55%. This indicates that GPCR experiences smaller price fluctuations and is considered to be less risky than PLRZ based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GPCR	PLRZ	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.49%	33.55%	-20.06%
Volatility (6M) Calculated over the trailing 6-month period	82.86%	140.96%	-58.10%
Volatility (1Y) Calculated over the trailing 1-year period	118.97%	223.99%	-105.02%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	99.02%	375.08%	-276.06%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	99.02%	375.08%	-276.06%

Dividends

GPCR vs. PLRZ - Dividend Comparison

Neither GPCR nor PLRZ has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both GPCR and PLRZ in my portfolio?

GPCR and PLRZ have a correlation of 0.06, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, GPCR or PLRZ?

PLRZ has higher volatility (33.55%) compared to GPCR (13.49%). In terms of maximum drawdown, GPCR dropped -80.96% vs PLRZ's -99.94%.

Which has better risk-adjusted returns?

PLRZ currently has the higher Sharpe Ratio (0.80 vs 0.60), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.