GPCR vs. NVO

Last updated Aug 1, 2026

GPCR (Structure Therapeutics Inc. American Depositary Shares) and NVO (Novo Nordisk A/S) are both stocks. Both are in the Healthcare sector — GPCR in Biotechnology, NVO in Drug Manufacturers - General. Over the past 3 years, GPCR returned 9.67%/yr vs -14.32%/yr for NVO. Their 0.17 correlation means their historical movements had little consistent relationship.

Performance

GPCR vs. NVO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Structure Therapeutics Inc. American Depositary Shares (GPCR) and Novo Nordisk A/S (NVO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GPCR achieves a -30.93% return, which is significantly lower than NVO's -4.23% return.

GPCR

• 1D: -2.89%
• 1M: -10.12%
• 6M: -45.69%
• YTD: -30.93%
• 1Y: 173.11%
• 3Y*: 9.67%
• 5Y*: —
• 10Y*: —
• ALL TIME*: 20.59%

NVO

• 1D: -8.78%
• 1M: -6.64%
• 6M: -18.01%
• YTD: -4.23%
• 1Y: 2.25%
• 3Y*: -14.32%
• 5Y*: 2.48%
• 10Y*: 7.55%
• ALL TIME*: 14.37%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
GPCR Structure Therapeutics Inc. American Depositary Shares	$23.87M	$28.91M	$32.91M
NVO Novo Nordisk A/S	$504.41M	$480.49M	$577.88M

GPCR vs. NVO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
GPCR Structure Therapeutics Inc. American Depositary Shares	-30.93%	156.45%	-33.46%	63.04%
NVO Novo Nordisk A/S	-4.23%	-39.22%	-15.93%	58.35%

Correlation

The correlation between GPCR and NVO is 0.14, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.14
Correlation (3Y) Balances recent behavior with more history.	0.17
Correlation (All Time) Calculated using the full available price history since Feb 3, 2023	0.17

Fundamentals

Market Cap GPCR : $2.77B NVO : $209.19B
EPS GPCR : -$2.69 NVO : DKK 27.42
PB Ratio GPCR : 2.40 NVO : 6.70
Total Revenue (TTM) GPCR : $0.00 NVO : DKK 327.80B
Gross Profit (TTM) GPCR : $0.00 NVO : DKK 268.30B
EBITDA (TTM) GPCR : -$191.27M NVO : DKK 181.54B

Return for Risk

GPCR vs. NVO — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

GPCR

GPCR Risk / Return Rank: 88
GPCR Sharpe Ratio Rank: 84
GPCR Sortino Ratio Rank: 97
GPCR Omega Ratio Rank: 93
GPCR Calmar Ratio Rank: 85
GPCR Martin Ratio Rank: 80

NVO

NVO Risk / Return Rank: 47
NVO Sharpe Ratio Rank: 48
NVO Sortino Ratio Rank: 45
NVO Omega Ratio Rank: 46
NVO Calmar Ratio Rank: 48
NVO Martin Ratio Rank: 48

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

GPCR vs. NVO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Structure Therapeutics Inc. American Depositary Shares (GPCR) and Novo Nordisk A/S (NVO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GPCR	NVO	Difference
Sharpe ratio: Return per unit of total volatility	1.43	0.10	+1.33
Sortino ratio: Return per unit of downside risk	3.87	0.47	+3.40
Omega ratio: Gain probability vs. loss probability	1.42	1.06	+0.36
Calmar ratio: Return relative to maximum drawdown	2.77	0.11	+2.66
Martin ratio: Return relative to average drawdown	5.13	0.20	+4.94

GPCR vs. NVO - Sharpe Ratio Comparison

The current GPCR Sharpe Ratio is 1.43, which is higher than the NVO Sharpe Ratio of 0.10. The chart below compares the historical Sharpe Ratios of GPCR and NVO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

GPCR vs. NVO - Drawdown Comparison

The maximum GPCR drawdown since its inception was -80.96%, which is greater than NVO's maximum drawdown of -74.70%. Use the drawdown chart below to compare losses from any high point for GPCR and NVO.

Drawdown Indicators

	GPCR	NVO	Difference
Max Drawdown Largest peak-to-trough decline	-80.96%	-74.70%	-6.26%
Max Drawdown (1Y) Largest decline over 1 year	-61.74%	-43.67%	-18.07%
Max Drawdown (3Y) Largest decline over 3 years	-80.96%	-74.70%	-6.26%
Max Drawdown (5Y) Largest decline over 5 years	—	-74.70%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-74.70%	—
Current Drawdown Current decline from peak	-48.78%	-65.79%	+17.01%
Average Drawdown Average peak-to-trough decline	-42.26%	-17.93%	-24.33%
Ulcer Index Depth and duration of drawdowns from previous peaks	33.24%	23.97%	+9.27%

Volatility

GPCR vs. NVO - Volatility Comparison

Structure Therapeutics Inc. American Depositary Shares (GPCR) has a higher volatility of 15.41% compared to Novo Nordisk A/S (NVO) at 12.28%. This indicates that GPCR's price experiences larger fluctuations and is considered to be riskier than NVO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GPCR	NVO	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.41%	12.28%	+3.13%
Volatility (6M) Calculated over the trailing 6-month period	39.45%	36.87%	+2.58%
Volatility (1Y) Calculated over the trailing 1-year period	119.56%	46.77%	+72.79%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	97.38%	38.76%	+58.62%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	97.38%	32.76%	+64.62%

Dividends

GPCR vs. NVO - Dividend Comparison

GPCR has not paid dividends to shareholders, while NVO's dividend yield for the trailing twelve months is around 3.83%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
GPCR Structure Therapeutics Inc. American Depositary Shares	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
NVO Novo Nordisk A/S	3.83%	3.31%	1.68%	1.00%	1.20%	1.35%	1.87%	2.14%	1.45%	1.52%	2.87%	0.92%

Financials

Frequently Asked Questions

Can I hold both GPCR and NVO in my portfolio?

GPCR and NVO have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, GPCR or NVO?

GPCR has higher volatility (15.41%) compared to NVO (12.28%). In terms of maximum drawdown, GPCR dropped -80.96% vs NVO's -74.70%.

Which has better risk-adjusted returns?

GPCR currently has the higher Sharpe Ratio (1.43 vs 0.10), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.