GPCR vs. AZN

Last updated Apr 1, 2026

Compare and contrast key facts about Structure Therapeutics Inc. American Depositary Shares (GPCR) and AstraZeneca PLC (AZN).

Performance

GPCR vs. AZN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Structure Therapeutics Inc. American Depositary Shares (GPCR) and AstraZeneca PLC (AZN). The values are adjusted to include any dividend payments, if applicable.

GPCR vs. AZN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
GPCR Structure Therapeutics Inc. American Depositary Shares	-30.70%	156.45%	-33.46%	56.77%
AZN AstraZeneca PLC	9.51%	43.30%	-0.62%	8.41%

Fundamentals

EPS GPCR : -$3.62 AZN : $6.55
Total Revenue (TTM) GPCR : $0.00 AZN : $58.74B
Gross Profit (TTM) GPCR : $0.00 AZN : $48.11B
EBITDA (TTM) GPCR : -$238.30M AZN : $19.83B

Returns By Period

In the year-to-date period, GPCR achieves a -30.70% return, which is significantly lower than AZN's 9.51% return.

GPCR

• 1D: 9.70%
• 1M: -23.47%
• YTD: -30.70%
• 6M: 72.14%
• 1Y: 178.45%
• 3Y*: 26.54%
• 5Y*: —
• 10Y*: —

AZN

• 1D: 1.72%
• 1M: -5.39%
• YTD: 9.51%
• 6M: 31.22%
• 1Y: 37.92%
• 3Y*: 15.06%
• 5Y*: 17.44%
• 10Y*: 16.71%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

GPCR vs. AZN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GPCR

GPCR Risk / Return Rank: 87
GPCR Sharpe Ratio Rank: 83
GPCR Sortino Ratio Rank: 96
GPCR Omega Ratio Rank: 92
GPCR Calmar Ratio Rank: 84
GPCR Martin Ratio Rank: 81

AZN

AZN Risk / Return Rank: 83
AZN Sharpe Ratio Rank: 83
AZN Sortino Ratio Rank: 81
AZN Omega Ratio Rank: 78
AZN Calmar Ratio Rank: 87
AZN Martin Ratio Rank: 86

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GPCR vs. AZN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Structure Therapeutics Inc. American Depositary Shares (GPCR) and AstraZeneca PLC (AZN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	GPCR	AZN	Difference
Sharpe ratio Return per unit of total volatility	1.46	1.40	+0.06
Sortino ratio Return per unit of downside risk	3.85	2.07	+1.78
Omega ratio Gain probability vs. loss probability	1.43	1.27	+0.17
Calmar ratio Return relative to maximum drawdown	2.71	3.20	-0.49
Martin ratio Return relative to average drawdown	6.51	8.03	-1.52
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

GPCR vs. AZN - Sharpe Ratio Comparison

The current GPCR Sharpe Ratio is 1.46, which is comparable to the AZN Sharpe Ratio of 1.40. The chart below compares the historical Sharpe Ratios of GPCR and AZN, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	GPCR	AZN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.46	1.40	+0.06
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.74	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.67	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.22	0.51	-0.29

Correlation

The correlation between GPCR and AZN is 0.11, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

GPCR vs. AZN - Dividend Comparison

GPCR has not paid dividends to shareholders, while AZN's dividend yield for the trailing twelve months is around 2.70%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
GPCR Structure Therapeutics Inc. American Depositary Shares	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
AZN AstraZeneca PLC	2.70%	1.70%	2.27%	2.15%	2.12%	2.35%	2.80%	2.81%	3.69%	3.95%	5.01%	4.06%

Drawdowns

GPCR vs. AZN - Drawdown Comparison

The maximum GPCR drawdown since its inception was -80.96%, which is greater than AZN's maximum drawdown of -48.94%. Use the drawdown chart below to compare losses from any high point for GPCR and AZN.

Drawdown Indicators

	GPCR	AZN	Difference
Max Drawdown Largest peak-to-trough decline	-80.96%	-48.94%	-32.02%
Max Drawdown (1Y) Largest decline over 1 year	-53.15%	-12.24%	-40.91%
Max Drawdown (5Y) Largest decline over 5 years	—	-27.87%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-27.87%	—
Current Drawdown Current decline from peak	-48.61%	-5.39%	-43.22%
Average Drawdown Average peak-to-trough decline	-41.38%	-11.39%	-29.99%
Ulcer Index Depth and duration of drawdowns from previous peaks	22.10%	4.88%	+17.22%

Volatility

GPCR vs. AZN - Volatility Comparison

Structure Therapeutics Inc. American Depositary Shares (GPCR) has a higher volatility of 18.47% compared to AstraZeneca PLC (AZN) at 6.95%. This indicates that GPCR's price experiences larger fluctuations and is considered to be riskier than AZN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GPCR	AZN	Difference
Volatility (1M) Calculated over the trailing 1-month period	18.47%	6.95%	+11.52%
Volatility (6M) Calculated over the trailing 6-month period	84.72%	19.14%	+65.58%
Volatility (1Y) Calculated over the trailing 1-year period	123.40%	27.28%	+96.12%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	101.04%	23.83%	+77.21%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	101.04%	24.90%	+76.14%

Financials