GERM vs. XLVI

Last updated Jun 4, 2026

GERM (Amplify Treatments, Testing and Advancements ETF) and XLVI (State Street Health Care Select Sector SPDR Premium Income ETF) are both exchange-traded funds - GERM is a Health & Biotech Equities fund tracking the Prime Treatments, Testing and Advancements Index, while XLVI is a Derivative Income fund actively managed by State Street. GERM is passively managed, while XLVI is actively managed. GERM charges 0.68%/yr vs 0.35%/yr for XLVI.

Performance

GERM vs. XLVI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amplify Treatments, Testing and Advancements ETF (GERM) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

GERM

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: 0.00%
• 1Y: 0.00%
• 3Y*: —
• 5Y*: —
• 10Y*: —

XLVI

• 1D: 0.67%
• 1M: 2.30%
• YTD: -0.67%
• 6M: 0.76%
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

GERM vs. XLVI - Yearly Performance Comparison

	2026 (YTD)	2025
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	-0.67%	12.79%

GERM vs. XLVI - Sectors Allocation Comparison

Sectors	GERM	XLVI
Healthcare	99.3%	-
Financial Services	0.4%	100.6%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

GERM vs. XLVI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amplify Treatments, Testing and Advancements ETF (GERM) and State Street Health Care Select Sector SPDR Premium Income ETF (XLVI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	GERM	XLVI	Difference
Sharpe Ratio (All Time) Calculated using the full available price history	—	1.33	—

Drawdowns

GERM vs. XLVI - Drawdown Comparison

The maximum GERM drawdown since its inception was 0.00%, smaller than the maximum XLVI drawdown of -8.14%. Use the drawdown chart below to compare losses from any high point for GERM and XLVI.

Drawdown Indicators

	GERM	XLVI	Difference
Max Drawdown Largest peak-to-trough decline	0.00%	-8.14%	+8.14%
Max Drawdown (1Y) Largest decline over 1 year	0.00%	—	—
Current Drawdown Current decline from peak	0.00%	-4.02%	+4.02%
Average Drawdown Average peak-to-trough decline	0.00%	-1.95%	+1.95%
Ulcer Index Depth and duration of drawdowns from previous peaks	0.00%	—	—

Volatility

Volatility by Period

	GERM	XLVI	Difference
Volatility (1M) Calculated over the trailing 1-month period	0.00%	—	—
Volatility (6M) Calculated over the trailing 6-month period	0.00%	—	—
Volatility (1Y) Calculated over the trailing 1-year period	0.00%	10.94%	-10.94%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	0.00%	10.94%	-10.94%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	0.00%	10.94%	-10.94%

GERM vs. XLVI - Expense Ratio Comparison

GERM has a 0.68% expense ratio, which is higher than XLVI's 0.35% expense ratio.

Dividends

GERM vs. XLVI - Dividend Comparison

GERM has not paid dividends to shareholders, while XLVI's dividend yield for the trailing twelve months is around 11.53%.

Position	TTM	2025
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%
XLVI State Street Health Care Select Sector SPDR Premium Income ETF	11.53%	5.73%

Frequently Asked Questions

Which ETF is better, GERM or XLVI?

On fees, XLVI is cheaper at 0.35% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, GERM or XLVI?

XLVI is cheaper with a 0.35% expense ratio, compared with 0.68% for GERM.

Which ETF pays a higher dividend yield, GERM or XLVI?

XLVI has the higher dividend yield at 11.53%, compared with 0.00% for GERM.

What is the main difference between GERM and XLVI?

GERM is categorized as Health & Biotech Equities, while XLVI is Derivative Income. They also come from different issuers: Amplify and State Street. Their fees differ too: 0.68% for GERM and 0.35% for XLVI.