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GERM vs. SBIO
Performance
Return for Risk
Drawdowns
Volatility
Dividends

GERM vs. SBIO

Last updated Jul 14, 2026
Documentation

GERM (Amplify Treatments, Testing and Advancements ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - GERM tracks the Prime Treatments, Testing and Advancements Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past year, GERM returned 0.00% vs 102.40% for SBIO. GERM charges 0.68%/yr vs 0.50%/yr for SBIO.

Performance

GERM vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amplify Treatments, Testing and Advancements ETF (GERM) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

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Returns By Period

GERM

1D
0.00%
1M
0.00%
6M
0.00%
YTD
0.00%
1Y
0.00%
3Y*
—
5Y*
—
10Y*
—

SBIO

1D
-2.80%
1M
23.83%
6M
28.23%
YTD
27.56%
1Y
102.40%
3Y*
28.22%
5Y*
8.04%
10Y*
11.57%
*Multi-year figures are annualized to reflect compound growth (CAGR)

GERM vs. SBIO - Yearly Performance Comparison

2026 (YTD)20252024
GERM
Amplify Treatments, Testing and Advancements ETF		0.00%0.00%0.00%
SBIO
ALPS Medical Breakthroughs ETF		27.56%55.07%-6.08%

GERM vs. SBIO - Sectors Allocation Comparison

Sectors
GERM
SBIO

Healthcare

99.3%
100.0%

Financial Services

0.4%
-0.0%

Basic Materials

-

-

Communication Services

-

-

Consumer Cyclical

-

-

Consumer Defensive

-

-

Energy

-

-

Industrials

-

-

Real Estate

-

-

Technology

-

-

Utilities

-

-

Healthcare

GERM
99.3%
SBIO
100.0%

Financial Services

GERM
0.4%
SBIO
-0.0%

Basic Materials

GERM

-

SBIO

-

Communication Services

GERM

-

SBIO

-

Consumer Cyclical

GERM

-

SBIO

-

Consumer Defensive

GERM

-

SBIO

-

Energy

GERM

-

SBIO

-

Industrials

GERM

-

SBIO

-

Real Estate

GERM

-

SBIO

-

Technology

GERM

-

SBIO

-

Utilities

GERM

-

SBIO

-

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Amplify Treatments, Testing and Advancements ETF

ALPS Medical Breakthroughs ETF

Often compared with GERM:
GERM vs. ARKGGERM vs. GDOCGERM vs. EQRRGERM vs. XBIGERM vs. XLVGERM vs. IHEGERM vs. MDEV
Often compared with SBIO:
SBIO vs. XBISBIO vs. BBPSBIO vs. BBCSBIO vs. IBBSBIO vs. ARKGSBIO vs. PBESBIO vs. IBBQ

Return for Risk

GERM vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.
GERM

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

SBIO
SBIO Risk / Return Rank: 9595
Overall Rank
SBIO Sharpe Ratio Rank: 9696
Sharpe Ratio Rank
SBIO Sortino Ratio Rank: 9595
Sortino Ratio Rank
SBIO Omega Ratio Rank: 9292
Omega Ratio Rank
SBIO Calmar Ratio Rank: 9797
Calmar Ratio Rank
SBIO Martin Ratio Rank: 9595
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GERM vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amplify Treatments, Testing and Advancements ETF (GERM) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

GERMSBIODifference
Sharpe ratioReturn per unit of total volatility

—

3.37

—

Sortino ratioReturn per unit of downside risk

—

4.16

—

Omega ratioGain probability vs. loss probability

—

1.50

—

Calmar ratioReturn relative to maximum drawdown

—

8.14

—

Martin ratioReturn relative to average drawdown

—

22.64

—

GERM vs. SBIO - Sharpe Ratio Comparison

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Drawdowns

GERM vs. SBIO - Drawdown Comparison

The maximum GERM drawdown since its inception was 0.00%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for GERM and SBIO.

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Drawdown Indicators

GERMSBIODifference

Max Drawdown

Largest peak-to-trough decline

0.00%

-63.06%

+63.06%

Max Drawdown (1Y)

Largest decline over 1 year

0.00%

-12.66%

+12.66%

Max Drawdown (3Y)

Largest decline over 3 years

—

-42.44%

—

Max Drawdown (5Y)

Largest decline over 5 years

—

-52.49%

—

Max Drawdown (10Y)

Largest decline over 10 years

—

-63.06%

—

Current Drawdown

Current decline from peak

0.00%

-5.23%

+5.23%

Average Drawdown

Average peak-to-trough decline

0.00%

-28.24%

+28.24%

Ulcer Index

Depth and duration of drawdowns from previous peaks

0.00%

4.54%

-4.54%

Volatility

GERM vs. SBIO - Volatility Comparison

The current volatility for Amplify Treatments, Testing and Advancements ETF (GERM) is 0.00%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 10.02%. This indicates that GERM experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

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Volatility by Period

GERMSBIODifference

Volatility (1M)

Calculated over the trailing 1-month period

0.00%

10.02%

-10.02%

Volatility (6M)

Calculated over the trailing 6-month period

0.00%

23.95%

-23.95%

Volatility (1Y)

Calculated over the trailing 1-year period

0.00%

30.65%

-30.65%

Volatility (5Y)

Calculated over the trailing 5-year period, annualized

0.00%

33.88%

-33.88%

Volatility (10Y)

Calculated over the trailing 10-year period, annualized

0.00%

33.16%

-33.16%

GERM vs. SBIO - Expense Ratio Comparison

GERM has a 0.68% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

GERM vs. SBIO - Dividend Comparison

Neither GERM nor SBIO has paid dividends to shareholders.

PositionTTM202520242023202220212020201920182017
GERM
Amplify Treatments, Testing and Advancements ETF		0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%
SBIO
ALPS Medical Breakthroughs ETF		0.00%0.00%3.55%0.22%0.00%0.00%0.00%0.04%2.79%1.77%

Frequently Asked Questions

SBIO has higher volatility (10.02%) compared to GERM (0.00%). In terms of maximum drawdown, GERM dropped 0.00% vs SBIO's -63.06%.

On 1-year performance, SBIO leads with 102.40% vs 0.00% for GERM. On fees, SBIO is cheaper at 0.50% per year. On volatility, GERM has been the lower-risk option at 0.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Over the 1-year period, SBIO has performed better with a 102.40% return vs 0.00%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

SBIO is cheaper with a 0.50% expense ratio, compared with 0.68% for GERM.

GERM and SBIO have nearly identical dividend yields, around 0.00%.

GERM tracks Prime Treatments, Testing and Advancements Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: Amplify and SS&C. Their fees differ too: 0.68% for GERM and 0.50% for SBIO.

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