GERM vs. SBIO

Last updated Jun 23, 2026

GERM (Amplify Treatments, Testing and Advancements ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - GERM tracks the Prime Treatments, Testing and Advancements Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past year, GERM returned 0.00% vs 95.53% for SBIO. GERM charges 0.68%/yr vs 0.50%/yr for SBIO.

Performance

GERM vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amplify Treatments, Testing and Advancements ETF (GERM) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

GERM

• 1D: 0.00%
• 1M: 0.00%
• YTD: 0.00%
• 6M: 0.00%
• 1Y: 0.00%
• 3Y*: —
• 5Y*: —
• 10Y*: —

SBIO

• 1D: 6.44%
• 1M: 10.06%
• YTD: 14.53%
• 6M: 12.40%
• 1Y: 95.53%
• 3Y*: 23.70%
• 5Y*: 4.51%
• 10Y*: 11.14%

*Multi-year figures are annualized to reflect compound growth (CAGR)

GERM vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	14.53%	55.07%	-6.08%

GERM vs. SBIO - Sectors Allocation Comparison

Sectors	GERM	SBIO
Healthcare	99.3%	100.0%
Financial Services	0.4%	-0.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

GERM vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GERM

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

SBIO

SBIO Risk / Return Rank: 91
SBIO Sharpe Ratio Rank: 93
SBIO Sortino Ratio Rank: 90
SBIO Omega Ratio Rank: 83
SBIO Calmar Ratio Rank: 95
SBIO Martin Ratio Rank: 91

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GERM vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amplify Treatments, Testing and Advancements ETF (GERM) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GERM	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	—	3.16	—
Sortino ratio: Return per unit of downside risk	—	4.03	—
Omega ratio: Gain probability vs. loss probability	—	1.48	—
Calmar ratio: Return relative to maximum drawdown	—	7.59	—
Martin ratio: Return relative to average drawdown	—	21.16	—

Drawdowns

GERM vs. SBIO - Drawdown Comparison

The maximum GERM drawdown since its inception was 0.00%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for GERM and SBIO.

Drawdown Indicators

	GERM	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	0.00%	-63.06%	+63.06%
Max Drawdown (1Y) Largest decline over 1 year	0.00%	-12.66%	+12.66%
Max Drawdown (3Y) Largest decline over 3 years	—	-42.44%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-53.10%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-63.06%	—
Current Drawdown Current decline from peak	0.00%	-4.33%	+4.33%
Average Drawdown Average peak-to-trough decline	0.00%	-28.37%	+28.37%
Ulcer Index Depth and duration of drawdowns from previous peaks	0.00%	4.53%	-4.53%

Volatility

GERM vs. SBIO - Volatility Comparison

The current volatility for Amplify Treatments, Testing and Advancements ETF (GERM) is 0.00%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 11.14%. This indicates that GERM experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GERM	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	0.00%	11.14%	-11.14%
Volatility (6M) Calculated over the trailing 6-month period	0.00%	23.77%	-23.77%
Volatility (1Y) Calculated over the trailing 1-year period	0.00%	30.46%	-30.46%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	0.00%	33.75%	-33.75%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	0.00%	33.23%	-33.23%

GERM vs. SBIO - Expense Ratio Comparison

GERM has a 0.68% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

GERM vs. SBIO - Dividend Comparison

Neither GERM nor SBIO has paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
GERM Amplify Treatments, Testing and Advancements ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%

Frequently Asked Questions

Which is riskier, GERM or SBIO?

SBIO has higher volatility (11.14%) compared to GERM (0.00%). In terms of maximum drawdown, GERM dropped 0.00% vs SBIO's -63.06%.

Which ETF is better, GERM or SBIO?

On 1-year performance, SBIO leads with 95.53% vs 0.00% for GERM. On fees, SBIO is cheaper at 0.50% per year. On volatility, GERM has been the lower-risk option at 0.00%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, GERM or SBIO?

Over the 1-year period, SBIO has performed better with a 95.53% return vs 0.00%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, GERM or SBIO?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.68% for GERM.

Which ETF pays a higher dividend yield, GERM or SBIO?

GERM and SBIO have nearly identical dividend yields, around 0.00%.

What is the main difference between GERM and SBIO?

GERM tracks Prime Treatments, Testing and Advancements Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: Amplify and SS&C. Their fees differ too: 0.68% for GERM and 0.50% for SBIO.