ENFR vs. SBIO

Last updated Apr 2, 2026

Compare and contrast key facts about Alerian Energy Infrastructure ETF (ENFR) and ALPS Medical Breakthroughs ETF (SBIO).

ENFR and SBIO are both exchange-traded funds (ETFs), meaning they are traded on stock exchanges and can be bought and sold throughout the day. ENFR is a passively managed fund by SS&C that tracks the performance of the Alerian Midstream Energy Select Index. It was launched on Nov 1, 2013. SBIO is a passively managed fund by SS&C that tracks the performance of the S-Network Medical Breakthroughs Index. It was launched on Dec 31, 2014. Both ENFR and SBIO are passive ETFs, meaning that they are not actively managed but aim to replicate the performance of the underlying index as closely as possible.

Performance

ENFR vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Alerian Energy Infrastructure ETF (ENFR) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

ENFR vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ENFR Alerian Energy Infrastructure ETF	20.63%	5.88%	42.17%	15.63%	17.48%	39.97%	-24.14%	21.60%	-18.67%	-0.19%
SBIO ALPS Medical Breakthroughs ETF	3.20%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%

Returns By Period

In the year-to-date period, ENFR achieves a 20.63% return, which is significantly higher than SBIO's 3.20% return. Over the past 10 years, ENFR has outperformed SBIO with an annualized return of 13.43%, while SBIO has yielded a comparatively lower 9.75% annualized return.

ENFR

• 1D: -1.81%
• 1M: -0.03%
• YTD: 20.63%
• 6M: 19.00%
• 1Y: 19.00%
• 3Y*: 27.90%
• 5Y*: 23.14%
• 10Y*: 13.43%

SBIO

• 1D: 0.99%
• 1M: 3.89%
• YTD: 3.20%
• 6M: 36.23%
• 1Y: 95.78%
• 3Y*: 26.37%
• 5Y*: 1.76%
• 10Y*: 9.75%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ENFR vs. SBIO - Expense Ratio Comparison

ENFR has a 0.35% expense ratio, which is lower than SBIO's 0.50% expense ratio.

SBIO

ALPS Medical Breakthroughs ETF

ENFR

Alerian Energy Infrastructure ETF

Return for Risk

ENFR vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ENFR

ENFR Risk / Return Rank: 52
ENFR Sharpe Ratio Rank: 57
ENFR Sortino Ratio Rank: 50
ENFR Omega Ratio Rank: 55
ENFR Calmar Ratio Rank: 50
ENFR Martin Ratio Rank: 45

SBIO

SBIO Risk / Return Rank: 96
SBIO Sharpe Ratio Rank: 97
SBIO Sortino Ratio Rank: 97
SBIO Omega Ratio Rank: 94
SBIO Calmar Ratio Rank: 98
SBIO Martin Ratio Rank: 97

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ENFR vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Alerian Energy Infrastructure ETF (ENFR) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ENFR	SBIO	Difference
Sharpe ratio Return per unit of total volatility	1.06	2.92	-1.86
Sortino ratio Return per unit of downside risk	1.41	3.57	-2.16
Omega ratio Gain probability vs. loss probability	1.22	1.45	-0.23
Calmar ratio Return relative to maximum drawdown	1.36	5.66	-4.30
Martin ratio Return relative to average drawdown	4.49	19.94	-15.45
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ENFR vs. SBIO - Sharpe Ratio Comparison

The current ENFR Sharpe Ratio is 1.06, which is lower than the SBIO Sharpe Ratio of 2.92. The chart below compares the historical Sharpe Ratios of ENFR and SBIO, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	ENFR	SBIO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.06	2.92	-1.86
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	1.21	0.05	+1.16
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.54	0.29	+0.25
Sharpe Ratio (All Time) Calculated using the full available price history	0.34	0.23	+0.11

Correlation

The correlation between ENFR and SBIO is 0.30, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

ENFR vs. SBIO - Dividend Comparison

ENFR's dividend yield for the trailing twelve months is around 4.09%, while SBIO has not paid dividends to shareholders.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
ENFR Alerian Energy Infrastructure ETF	4.09%	4.77%	4.41%	5.48%	5.23%	7.86%	7.57%	5.81%	3.98%	2.98%	3.31%	3.34%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%

Drawdowns

ENFR vs. SBIO - Drawdown Comparison

The maximum ENFR drawdown since its inception was -68.28%, which is greater than SBIO's maximum drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for ENFR and SBIO.

Drawdown Indicators

	ENFR	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-68.28%	-63.06%	-5.22%
Max Drawdown (1Y) Largest decline over 1 year	-14.80%	-15.08%	+0.28%
Max Drawdown (5Y) Largest decline over 5 years	-20.29%	-53.67%	+33.38%
Max Drawdown (10Y) Largest decline over 10 years	-62.64%	-63.06%	+0.42%
Current Drawdown Current decline from peak	-3.94%	-13.79%	+9.85%
Average Drawdown Average peak-to-trough decline	-16.16%	-28.70%	+12.54%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.48%	4.28%	+0.20%

Volatility

ENFR vs. SBIO - Volatility Comparison

The current volatility for Alerian Energy Infrastructure ETF (ENFR) is 4.18%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 12.61%. This indicates that ENFR experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ENFR	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	4.18%	12.61%	-8.43%
Volatility (6M) Calculated over the trailing 6-month period	10.39%	22.09%	-11.70%
Volatility (1Y) Calculated over the trailing 1-year period	18.01%	33.43%	-15.42%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	19.19%	33.55%	-14.36%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	24.74%	33.34%	-8.60%