EIS vs. SBIO

Last updated Jul 21, 2026

EIS (iShares MSCI Israel ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both exchange-traded funds - EIS is a Foreign Large Cap Equities fund tracking the MSCI Israel Capped Investable Market Index (Net), while SBIO is a Health & Biotech Equities fund tracking the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 10 years, EIS returned 10.67%/yr vs 10.96%/yr for SBIO. At a 0.47 correlation, their price movements are largely independent. EIS charges 0.59%/yr vs 0.50%/yr for SBIO.

Performance

EIS vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in iShares MSCI Israel ETF (EIS) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, EIS achieves a 8.44% return, which is significantly lower than SBIO's 24.17% return. Both investments have delivered pretty close results over the past 10 years, with EIS having a 10.67% annualized return and SBIO not far ahead at 10.96%.

EIS

• 1D: -1.11%
• 1M: -3.55%
• 6M: 0.14%
• YTD: 8.44%
• 1Y: 27.52%
• 3Y*: 29.22%
• 5Y*: 13.09%
• 10Y*: 10.67%
• ALL TIME*: 6.83%

SBIO

• 1D: -2.45%
• 1M: 15.41%
• 6M: 24.53%
• YTD: 24.17%
• 1Y: 93.61%
• 3Y*: 27.21%
• 5Y*: 6.86%
• 10Y*: 10.96%
• ALL TIME*: 9.19%

*Multi-year figures are annualized to reflect compound growth (CAGR)

EIS vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
EIS iShares MSCI Israel ETF	8.44%	45.11%	34.50%	5.48%	-27.05%	22.83%	12.01%	20.93%	-4.84%	12.77%
SBIO ALPS Medical Breakthroughs ETF	24.17%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%

Correlation

The correlation between EIS and SBIO is 0.31, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.31
Correlation (3Y) Calculated over the trailing 3-year period	0.36
Correlation (5Y) Calculated over the trailing 5-year period	0.43
Correlation (10Y) Calculated over the trailing 10-year period	0.48
Correlation (All Time) Calculated using the full available price history since Dec 31, 2014	0.47

The correlation between EIS and SBIO shifts across timeframes, from 0.31 (1 year) to 0.48 (10 years), reflecting how their relationship changes across market environments.

EIS vs. SBIO - Sectors Allocation Comparison

Sectors	EIS	SBIO
Financial Services	33.4%	-0.0%
Technology	20.3%	-
Industrials	10.4%	-
Healthcare	9.5%	100.0%
Real Estate	8.5%	-
Utilities	6.6%	-
Consumer Cyclical	2.8%	-
Communication Services	2.3%	-
Energy	1.9%	-
Consumer Defensive	1.8%	-
Basic Materials	1.6%	-

Return for Risk

EIS vs. SBIO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

EIS

EIS Risk / Return Rank: 46
EIS Sharpe Ratio Rank: 44
EIS Sortino Ratio Rank: 45
EIS Omega Ratio Rank: 42
EIS Calmar Ratio Rank: 52
EIS Martin Ratio Rank: 45

SBIO

SBIO Risk / Return Rank: 95
SBIO Sharpe Ratio Rank: 96
SBIO Sortino Ratio Rank: 94
SBIO Omega Ratio Rank: 91
SBIO Calmar Ratio Rank: 97
SBIO Martin Ratio Rank: 95

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

EIS vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for iShares MSCI Israel ETF (EIS) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	EIS	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	1.19	3.07	-1.87
Sortino ratio: Return per unit of downside risk	1.77	3.87	-2.10
Omega ratio: Gain probability vs. loss probability	1.22	1.46	-0.25
Calmar ratio: Return relative to maximum drawdown	1.99	7.44	-5.45
Martin ratio: Return relative to average drawdown	5.51	20.36	-14.84

EIS vs. SBIO - Sharpe Ratio Comparison

The current EIS Sharpe Ratio is 1.19, which is lower than the SBIO Sharpe Ratio of 3.07. The chart below compares the historical Sharpe Ratios of EIS and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

EIS vs. SBIO - Drawdown Comparison

The maximum EIS drawdown since its inception was -51.94%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for EIS and SBIO.

Drawdown Indicators

	EIS	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-51.94%	-63.06%	+11.12%
Max Drawdown (1Y) Largest decline over 1 year	-13.90%	-12.66%	-1.24%
Max Drawdown (3Y) Largest decline over 3 years	-22.29%	-42.44%	+20.15%
Max Drawdown (5Y) Largest decline over 5 years	-41.88%	-52.49%	+10.61%
Max Drawdown (10Y) Largest decline over 10 years	-41.88%	-63.06%	+21.18%
Current Drawdown Current decline from peak	-13.34%	-7.75%	-5.59%
Average Drawdown Average peak-to-trough decline	-13.88%	-28.20%	+14.32%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.00%	4.61%	+0.39%

Volatility

EIS vs. SBIO - Volatility Comparison

The current volatility for iShares MSCI Israel ETF (EIS) is 6.63%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 11.36%. This indicates that EIS experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	EIS	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.63%	11.36%	-4.73%
Volatility (6M) Calculated over the trailing 6-month period	18.49%	24.09%	-5.60%
Volatility (1Y) Calculated over the trailing 1-year period	23.19%	30.73%	-7.54%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	22.28%	33.90%	-11.62%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	21.27%	33.16%	-11.89%

EIS vs. SBIO - Expense Ratio Comparison

EIS has a 0.59% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

EIS vs. SBIO - Dividend Comparison

EIS's dividend yield for the trailing twelve months is around 1.57%, while SBIO has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
EIS iShares MSCI Israel ETF	1.57%	1.44%	1.38%	1.39%	1.66%	1.04%	0.16%	2.06%	0.87%	2.02%	1.78%	2.55%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%

Frequently Asked Questions

Can I hold both EIS and SBIO in my portfolio?

EIS and SBIO have a correlation of 0.31, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, EIS or SBIO?

SBIO has higher volatility (11.36%) compared to EIS (6.63%). In terms of maximum drawdown, EIS dropped -51.94% vs SBIO's -63.06%.

Which ETF is better, EIS or SBIO?

On 10-year performance, SBIO leads with 10.96% vs 10.67% for EIS. On fees, SBIO is cheaper at 0.50% per year. On volatility, EIS has been the lower-risk option at 6.63%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, EIS or SBIO?

Over the 10-year period, SBIO has performed better with a 10.96% return vs 10.67%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, EIS or SBIO?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.59% for EIS.

Which ETF pays a higher dividend yield, EIS or SBIO?

EIS has the higher dividend yield at 1.57%, compared with 0.00% for SBIO.

What is the main difference between EIS and SBIO?

EIS is categorized as Foreign Large Cap Equities, while SBIO is Health & Biotech Equities. EIS tracks MSCI Israel Capped Investable Market Index (Net), while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: iShares and SS&C. Their fees differ too: 0.59% for EIS and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (3.07 vs 1.19), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.