ANAB vs. RSI

Last updated Jun 23, 2026

ANAB (AnaptysBio, Inc.) and RSI (Rush Street Interactive, Inc.) are both stocks. ANAB operates in Biotechnology (Healthcare), while RSI operates in Gambling (Consumer Cyclical). Over the past 5 years, ANAB returned 29.27%/yr vs 19.15%/yr for RSI. At a 0.23 correlation, their price movements are largely independent.

Performance

ANAB vs. RSI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AnaptysBio, Inc. (ANAB) and Rush Street Interactive, Inc. (RSI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ANAB achieves a 85.61% return, which is significantly higher than RSI's 57.08% return.

ANAB

• 1D: 4.31%
• 1M: 0.47%
• YTD: 85.61%
• 6M: 78.79%
• 1Y: 288.37%
• 3Y*: 64.43%
• 5Y*: 29.27%
• 10Y*: —

RSI

• 1D: 4.92%
• 1M: 12.79%
• YTD: 57.08%
• 6M: 55.32%
• 1Y: 120.52%
• 3Y*: 116.44%
• 5Y*: 19.15%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ANAB vs. RSI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
ANAB AnaptysBio, Inc.	85.61%	266.16%	-38.19%	-30.88%	-10.82%	61.63%	39.25%
RSI Rush Street Interactive, Inc.	57.08%	41.62%	205.57%	25.07%	-78.24%	-23.79%	125.05%

Correlation

The correlation between ANAB and RSI is 0.04, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.04
Correlation (3Y) Calculated over the trailing 3-year period	0.19
Correlation (5Y) Calculated over the trailing 5-year period	0.27
Correlation (All Time) Calculated using the full available price history since Apr 23, 2020	0.23

The correlation between ANAB and RSI shifts across timeframes, from 0.04 (1 year) to 0.27 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ANAB : $1.72B RSI : $3.26B
EPS ANAB : -$0.91 RSI : $0.54
PS Ratio ANAB : 7.61 RSI : 2.48
PB Ratio ANAB : 135.03 RSI : 20.49
Total Revenue (TTM) ANAB : $232.39M RSI : $1.24B
Gross Profit (TTM) ANAB : $245.59M RSI : $433.41M
EBITDA (TTM) ANAB : $52.72M RSI : $162.04M

Return for Risk

ANAB vs. RSI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ANAB

ANAB Risk / Return Rank: 97
ANAB Sharpe Ratio Rank: 98
ANAB Sortino Ratio Rank: 96
ANAB Omega Ratio Rank: 95
ANAB Calmar Ratio Rank: 98
ANAB Martin Ratio Rank: 97

RSI

RSI Risk / Return Rank: 90
RSI Sharpe Ratio Rank: 92
RSI Sortino Ratio Rank: 91
RSI Omega Ratio Rank: 90
RSI Calmar Ratio Rank: 89
RSI Martin Ratio Rank: 87

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ANAB vs. RSI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AnaptysBio, Inc. (ANAB) and Rush Street Interactive, Inc. (RSI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ANAB	RSI	Difference
Sharpe ratio: Return per unit of total volatility	4.20	2.34	+1.86
Sortino ratio: Return per unit of downside risk	4.17	3.17	+0.99
Omega ratio: Gain probability vs. loss probability	1.56	1.42	+0.14
Calmar ratio: Return relative to maximum drawdown	10.32	4.11	+6.21
Martin ratio: Return relative to average drawdown	24.45	9.40	+15.05

ANAB vs. RSI - Sharpe Ratio Comparison

The current ANAB Sharpe Ratio is 4.20, which is higher than the RSI Sharpe Ratio of 2.34. The chart below compares the historical Sharpe Ratios of ANAB and RSI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ANAB vs. RSI - Drawdown Comparison

The maximum ANAB drawdown since its inception was -92.08%, roughly equal to the maximum RSI drawdown of -88.92%. Use the drawdown chart below to compare losses from any high point for ANAB and RSI.

Drawdown Indicators

	ANAB	RSI	Difference
Max Drawdown Largest peak-to-trough decline	-92.08%	-88.92%	-3.16%
Max Drawdown (1Y) Largest decline over 1 year	-28.15%	-29.47%	+1.32%
Max Drawdown (3Y) Largest decline over 3 years	-69.32%	-42.04%	-27.28%
Max Drawdown (5Y) Largest decline over 5 years	-69.32%	-86.88%	+17.56%
Current Drawdown Current decline from peak	-30.00%	0.00%	-30.00%
Average Drawdown Average peak-to-trough decline	-64.57%	-50.07%	-14.50%
Ulcer Index Depth and duration of drawdowns from previous peaks	11.86%	12.88%	-1.02%

Volatility

ANAB vs. RSI - Volatility Comparison

AnaptysBio, Inc. (ANAB) and Rush Street Interactive, Inc. (RSI) have volatilities of 13.01% and 13.03%, respectively, indicating that both stocks experience similar levels of price fluctuations. This suggests that the risk associated with both stocks, as measured by volatility, is nearly the same. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ANAB	RSI	Difference
Volatility (1M) Calculated over the trailing 1-month period	13.01%	13.03%	-0.02%
Volatility (6M) Calculated over the trailing 6-month period	46.85%	32.93%	+13.92%
Volatility (1Y) Calculated over the trailing 1-year period	69.26%	51.90%	+17.36%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	65.42%	62.02%	+3.40%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	75.40%	60.56%	+14.84%

Dividends

ANAB vs. RSI - Dividend Comparison

Neither ANAB nor RSI has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ANAB and RSI in my portfolio?

ANAB and RSI have a correlation of 0.04, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ANAB or RSI?

RSI has higher volatility (13.03%) compared to ANAB (13.01%). In terms of maximum drawdown, ANAB dropped -92.08% vs RSI's -88.92%.

Which has better risk-adjusted returns?

ANAB currently has the higher Sharpe Ratio (4.20 vs 2.34), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.