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ANAB vs. VOO
Performance
Return for Risk
Drawdowns
Volatility
Dividends

ANAB vs. VOO

Last updated Jun 4, 2026

ANAB (AnaptysBio, Inc.) is a stock, while VOO (Vanguard S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 5 years, ANAB returned 27.51%/yr vs 13.90%/yr for VOO. At a 0.29 correlation, their price movements are largely independent.

Performance

ANAB vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AnaptysBio, Inc. (ANAB) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

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Returns By Period

In the year-to-date period, ANAB achieves a 58.54% return, which is significantly higher than VOO's 10.91% return.

ANAB

1D
-0.04%
1M
-26.57%
YTD
58.54%
6M
75.64%
1Y
226.79%
3Y*
60.13%
5Y*
27.51%
10Y*
—

VOO

1D
-0.70%
1M
5.04%
YTD
10.91%
6M
10.93%
1Y
28.04%
3Y*
22.44%
5Y*
13.90%
10Y*
15.56%
*Multi-year figures are annualized to reflect compound growth (CAGR)

ANAB vs. VOO - Yearly Performance Comparison

2026 (YTD)202520242023202220212020201920182017
ANAB
AnaptysBio, Inc.		58.54%266.16%-38.19%-30.88%-10.82%61.63%32.31%-74.53%-36.67%492.47%
VOO
Vanguard S&P 500 ETF		10.91%17.82%24.98%26.32%-18.17%28.79%18.32%31.37%-4.50%18.74%

Correlation

The correlation between ANAB and VOO is 0.24, which is low. Their price movements are largely independent, making them effective diversification partners.

Correlation
Correlation (1Y)
Calculated over the trailing 1-year period

0.24

Correlation (3Y)
Calculated over the trailing 3-year period

0.23

Correlation (5Y)
Calculated over the trailing 5-year period

0.28

Correlation (All Time)
Calculated using the full available price history since Jan 27, 2017

0.29

Compare stocks, funds, or ETFs

Search for stocks, ETFs, and funds for a quick comparison or use the comparison tool for more options.

AnaptysBio, Inc.

Vanguard S&P 500 ETF

Often compared with ANAB:
ANAB vs. BKKTANAB vs. AMDANAB vs. GOOGLANAB vs. ALABANAB vs. RSIANAB vs. AVGOANAB vs. APH
Often compared with VOO:
VOO vs. VTIVOO vs. QQQVOO vs. SCHDVOO vs. VTVOO vs. SPYVOO vs. FXAIXVOO vs. IVV

Return for Risk

ANAB vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.
ANAB
ANAB Risk / Return Rank: 9494
Overall Rank
ANAB Sharpe Ratio Rank: 9595
Sharpe Ratio Rank
ANAB Sortino Ratio Rank: 9393
Sortino Ratio Rank
ANAB Omega Ratio Rank: 9292
Omega Ratio Rank
ANAB Calmar Ratio Rank: 9696
Calmar Ratio Rank
ANAB Martin Ratio Rank: 9696
Martin Ratio Rank
VOO
VOO Risk / Return Rank: 7070
Overall Rank
VOO Sharpe Ratio Rank: 7171
Sharpe Ratio Rank
VOO Sortino Ratio Rank: 7070
Sortino Ratio Rank
VOO Omega Ratio Rank: 7070
Omega Ratio Rank
VOO Calmar Ratio Rank: 6262
Calmar Ratio Rank
VOO Martin Ratio Rank: 7575
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ANAB vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AnaptysBio, Inc. (ANAB) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

ANABVOODifference
Sharpe ratioReturn per unit of total volatility
3.24
2.39

+0.85

Sortino ratioReturn per unit of downside risk
3.63
3.25

+0.38

Omega ratioGain probability vs. loss probability

1.48

1.43

+0.05

Calmar ratioReturn relative to maximum drawdown

8.11

3.16

+4.95

Martin ratioReturn relative to average drawdown

20.93

14.73

+6.20

Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ANAB vs. VOO - Sharpe Ratio Comparison

The current ANAB Sharpe Ratio is 3.24, which is higher than the VOO Sharpe Ratio of 2.39. The chart below compares the historical Sharpe Ratios of ANAB and VOO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

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Sharpe Ratios by Period

ANABVOODifference

Sharpe Ratio (1Y)

Calculated over the trailing 1-year period

3.24

2.39

+0.85

Sharpe Ratio (5Y)

Calculated over the trailing 5-year period

0.42

0.83

-0.41

Sharpe Ratio (10Y)

Calculated over the trailing 10-year period

—

0.87

—

Sharpe Ratio (All Time)

Calculated using the full available price history

0.23

0.89

-0.65

Drawdowns

ANAB vs. VOO - Drawdown Comparison

The maximum ANAB drawdown since its inception was -92.08%, which is greater than VOO's maximum drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for ANAB and VOO.

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Drawdown Indicators

ANABVOODifference

Max Drawdown

Largest peak-to-trough decline

-92.08%

-33.99%

-58.09%

Max Drawdown (1Y)

Largest decline over 1 year

-28.15%

-8.90%

-19.25%

Max Drawdown (3Y)

Largest decline over 3 years

-69.32%

-18.69%

-50.63%

Max Drawdown (5Y)

Largest decline over 5 years

-69.32%

-24.52%

-44.80%

Max Drawdown (10Y)

Largest decline over 10 years

—

-33.99%

—

Current Drawdown

Current decline from peak

-40.21%

-0.70%

-39.51%

Average Drawdown

Average peak-to-trough decline

-64.74%

-3.69%

-61.05%

Ulcer Index

Depth and duration of drawdowns from previous peaks

10.92%

1.91%

+9.01%

Volatility

ANAB vs. VOO - Volatility Comparison

AnaptysBio, Inc. (ANAB) has a higher volatility of 11.47% compared to Vanguard S&P 500 ETF (VOO) at 2.84%. This indicates that ANAB's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

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Volatility by Period

ANABVOODifference

Volatility (1M)

Calculated over the trailing 1-month period

11.47%

2.84%

+8.63%

Volatility (6M)

Calculated over the trailing 6-month period

46.57%

8.90%

+37.67%

Volatility (1Y)

Calculated over the trailing 1-year period

70.75%

11.80%

+58.95%

Volatility (5Y)

Calculated over the trailing 5-year period, annualized

65.34%

16.81%

+48.53%

Volatility (10Y)

Calculated over the trailing 10-year period, annualized

75.51%

18.01%

+57.50%

Dividends

ANAB vs. VOO - Dividend Comparison

ANAB has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.03%.

PositionTTM20252024202320222021202020192018201720162015
ANAB
AnaptysBio, Inc.		0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%0.00%
VOO
Vanguard S&P 500 ETF		1.03%1.13%1.24%1.46%1.69%1.25%1.54%1.88%2.06%1.78%2.02%2.10%

Frequently Asked Questions

ANAB and VOO have a correlation of 0.24, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

ANAB has higher volatility (11.47%) compared to VOO (2.84%). In terms of maximum drawdown, ANAB dropped -92.08% vs VOO's -33.99%.

ANAB currently has the higher Sharpe Ratio (3.24 vs 2.39), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.

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